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Protein

Cholecystokinin

Gene

CCK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.By similarity4 Publications

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • digestion Source: UniProtKB
  • neuron migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 3 chains:
Cholecystokinin-70
Short name:
CCK70
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Gene namesi
Name:CCK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001057421 – 130CholecystokininSequence analysisAdd BLAST110
PropeptideiPRO_000001057521 – 481 PublicationAdd BLAST28
PeptideiPRO_000001057649 – 118Cholecystokinin-70CuratedAdd BLAST70
PeptideiPRO_0000010577111 – 118Cholecystokinin-88
PeptideiPRO_0000010578112 – 118Cholecystokinin-7By similarity7
PropeptideiPRO_0000010579122 – 1301 Publication9

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112Sulfotyrosine1 Publication1
Modified residuei118Phenylalanine amideBy similarity1
Modified residuei126SulfotyrosineBy similarity1
Modified residuei128SulfotyrosineBy similarity1

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiQ9PU41.

Expressioni

Tissue specificityi

In the small intestine, the major production site is around the vitelline diverticulum.1 Publication

Inductioni

By dietary protein, amino acids and medium-chain triacylglycerol.1 Publication

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019451.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiQ9PU41.
KOiK05226.
PhylomeDBiQ9PU41.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PU41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGGICICVL LAALSVSSLG QQPAGSHDGS PVAAELQQSL TEPHRHSRAP
60 70 80 90 100
SSAGPLKPAP RLDGSFEQRA TIGALLAKYL QQARKGSTGR FSVLGNRVQS
110 120 130
IDPTHRINDR DYMGWMDFGR RSAEEYEYSS
Length:130
Mass (Da):14,091
Last modified:May 1, 2000 - v1
Checksum:i05CEBE4BB10527C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251273 mRNA. Translation: CAB62203.1.
RefSeqiNP_001001741.1. NM_001001741.1.
UniGeneiGga.2441.

Genome annotation databases

GeneIDi414884.
KEGGigga:414884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251273 mRNA. Translation: CAB62203.1.
RefSeqiNP_001001741.1. NM_001001741.1.
UniGeneiGga.2441.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019451.

Proteomic databases

PaxDbiQ9PU41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414884.
KEGGigga:414884.

Organism-specific databases

CTDi885.

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiQ9PU41.
KOiK05226.
PhylomeDBiQ9PU41.

Miscellaneous databases

PROiQ9PU41.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKN_CHICK
AccessioniPrimary (citable) accession number: Q9PU41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.