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Protein

Cholecystokinin

Gene

CCK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes.By similarity4 Publications

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • digestion Source: UniProtKB
  • neuron migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 3 chains:
Cholecystokinin-70
Short name:
CCK70
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Gene namesi
Name:CCK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 130110CholecystokininSequence analysisPRO_0000010574Add
BLAST
Propeptidei21 – 48281 PublicationPRO_0000010575Add
BLAST
Peptidei49 – 11870Cholecystokinin-70CuratedPRO_0000010576Add
BLAST
Peptidei111 – 1188Cholecystokinin-8PRO_0000010577
Peptidei112 – 1187Cholecystokinin-7By similarityPRO_0000010578
Propeptidei122 – 13091 PublicationPRO_0000010579

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei112 – 1121Sulfotyrosine1 Publication
Modified residuei118 – 1181Phenylalanine amideBy similarity
Modified residuei126 – 1261SulfotyrosineBy similarity
Modified residuei128 – 1281SulfotyrosineBy similarity

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiQ9PU41.

Expressioni

Tissue specificityi

In the small intestine, the major production site is around the vitelline diverticulum.1 Publication

Inductioni

By dietary protein, amino acids and medium-chain triacylglycerol.1 Publication

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019451.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiQ9PU41.
KOiK05226.
PhylomeDBiQ9PU41.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PU41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGGICICVL LAALSVSSLG QQPAGSHDGS PVAAELQQSL TEPHRHSRAP
60 70 80 90 100
SSAGPLKPAP RLDGSFEQRA TIGALLAKYL QQARKGSTGR FSVLGNRVQS
110 120 130
IDPTHRINDR DYMGWMDFGR RSAEEYEYSS
Length:130
Mass (Da):14,091
Last modified:May 1, 2000 - v1
Checksum:i05CEBE4BB10527C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251273 mRNA. Translation: CAB62203.1.
RefSeqiNP_001001741.1. NM_001001741.1.
UniGeneiGga.2441.

Genome annotation databases

GeneIDi414884.
KEGGigga:414884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251273 mRNA. Translation: CAB62203.1.
RefSeqiNP_001001741.1. NM_001001741.1.
UniGeneiGga.2441.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019451.

Proteomic databases

PaxDbiQ9PU41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414884.
KEGGigga:414884.

Organism-specific databases

CTDi885.

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiQ9PU41.
KOiK05226.
PhylomeDBiQ9PU41.

Miscellaneous databases

NextBioi20818761.
PROiQ9PU41.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of ostrich and chicken cholecystokinin cDNA and intestinal peptides."
    Jonson L., Schoeman N., Saayman H., Naude R., Jensen H., Johnsen A.H.
    Peptides 21:1337-1344(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: White Plymouthrock1 Publication.
  2. "Cholecystokinin octapeptides purified from chinchilla and chicken brains."
    Fan Z.-W., Eng J., Miedel M., Hulmes J.D., Pan Y.-C., Yalow R.S.
    Brain Res. Bull. 18:757-760(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 111-118, SULFATION AT TYR-112.
    Tissue: Brain1 Publication.
  3. "Effects of cholecystokinin and gastrin on gastroduodenal motility and coordination in chickens."
    Martinez V., Jimenez M., Gonalons E., Vergara P.
    Life Sci. 52:191-198(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Central and NO mediated mechanisms are involved in the inhibitory effects of CCK on the chicken cecorectal area."
    Rodriguez-Sinovas A., Fernandez E., Gonalons E.
    Life Sci. 58:1869-1882(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "CCK is involved in both peripheral and central mechanisms controlling food intake in chickens."
    Rodriguez-Sinovas A., Fernandez E., Manteca X., Fernandez A.G., Gonalons E.
    Am. J. Physiol. 272:R334-R340(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Release and endogenous actions of the gastrin/cholecystokinin (CCK) family in the chicken."
    Furuse M.
    J. Exp. Zool. 283:448-454(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION.

Entry informationi

Entry nameiCCKN_CHICK
AccessioniPrimary (citable) accession number: Q9PU41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.