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Protein
Submitted name:

Tyrosine hydroxylase

Gene

tyrosine hydroxylase

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Fe2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi324IronUniRule annotation1
Metal bindingi329IronUniRule annotation1
Metal bindingi369IronUniRule annotation1

GO - Molecular functioni

  • iron ion binding Source: InterPro
  • tyrosine 3-monooxygenase activity Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

IronUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine hydroxylaseImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:tyrosine hydroxylaseImported
Synonyms:THImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

  • axon Source: Ensembl
  • cell Source: AgBase
  • cytoplasm Source: AgBase
  • cytoplasmic side of plasma membrane Source: Ensembl
  • melanosome membrane Source: Ensembl
  • nucleus Source: Ensembl
  • perikaryon Source: Ensembl
  • smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9PU40.

Expressioni

Gene expression databases

BgeeiENSGALG00000006551.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010566.

Structurei

3D structure databases

ProteinModelPortaliQ9PU40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 491BH4_AAA_HYDROXYL_2InterPro annotationAdd BLAST347

Phylogenomic databases

eggNOGiKOG3820. Eukaryota.
COG3186. LUCA.
GeneTreeiENSGT00390000010268.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ9PU40.
KOiK00501.
OrthoDBiEOG091G05MZ.
PhylomeDBiQ9PU40.
TreeFamiTF313327.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE
60 70 80 90 100
AAAAATDAAE STETIVFEEK DGRAMLNLFF MLKGAKTSPL SRALKVFETF
110 120 130 140 150
EAKIHHLETR LSRKPREGTA ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR
160 170 180 190 200
TTKEDKFHWF PRKICELDKC HHLVTKFDPD LDLDHPGYSD QVYRQRRKSI
210 220 230 240 250
AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH ACKEYLEAFN
260 270 280 290 300
LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVAGLLSA RDFLASLAFR
310 320 330 340 350
VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL
360 370 380 390 400
GATDEEIEKL ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE
410 420 430 440 450
PEVRDFDPDA AAVQPYQDQN YQPVYFVSES FSDAKNKLRN YAAHIKRPFS
460 470 480 490
VKYEPYTHSI ELLDSPQTIC HSLESVRDEL HSLINALNVI S
Length:491
Mass (Da):56,016
Last modified:May 1, 2000 - v1
Checksum:i6322F2D58E746930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000238 Genomic DNA. No translation available.
AJ251387 mRNA. Translation: CAB62388.1.
PIRiS40309.
RefSeqiNP_990136.1. NM_204805.2.
UniGeneiGga.327.

Genome annotation databases

EnsembliENSGALT00000074933; ENSGALP00000051175; ENSGALG00000029648.
GeneIDi395592.
KEGGigga:395592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000238 Genomic DNA. No translation available.
AJ251387 mRNA. Translation: CAB62388.1.
PIRiS40309.
RefSeqiNP_990136.1. NM_204805.2.
UniGeneiGga.327.

3D structure databases

ProteinModelPortaliQ9PU40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010566.

Proteomic databases

PaxDbiQ9PU40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000074933; ENSGALP00000051175; ENSGALG00000029648.
GeneIDi395592.
KEGGigga:395592.

Organism-specific databases

CTDi7054.

Phylogenomic databases

eggNOGiKOG3820. Eukaryota.
COG3186. LUCA.
GeneTreeiENSGT00390000010268.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ9PU40.
KOiK00501.
OrthoDBiEOG091G05MZ.
PhylomeDBiQ9PU40.
TreeFamiTF313327.

Gene expression databases

BgeeiENSGALG00000006551.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9PU40_CHICK
AccessioniPrimary (citable) accession number: Q9PU40
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.