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Protein
Submitted name:

Tyrosine hydroxylase

Gene

tyrosine hydroxylase

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Fe2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi324 – 3241IronUniRule annotation
Metal bindingi329 – 3291IronUniRule annotation
Metal bindingi369 – 3691IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. tyrosine 3-monooxygenase activity Source: InterPro

GO - Biological processi

  1. aromatic amino acid family metabolic process Source: InterPro
  2. dopamine biosynthetic process Source: Ensembl
  3. eating behavior Source: Ensembl
  4. embryonic camera-type eye morphogenesis Source: Ensembl
  5. epinephrine biosynthetic process Source: Ensembl
  6. eye photoreceptor cell development Source: Ensembl
  7. heart development Source: Ensembl
  8. learning Source: Ensembl
  9. locomotory behavior Source: Ensembl
  10. mating behavior Source: Ensembl
  11. memory Source: Ensembl
  12. norepinephrine biosynthetic process Source: Ensembl
  13. regulation of heart contraction Source: Ensembl
  14. response to ethanol Source: Ensembl
  15. response to hypoxia Source: Ensembl
  16. synaptic transmission, dopaminergic Source: Ensembl
  17. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

IronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_276476. Catecholamine biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine hydroxylaseImported
Gene namesi
Name:tyrosine hydroxylaseImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. melanosome membrane Source: Ensembl
  4. nucleus Source: Ensembl
  5. perikaryon Source: Ensembl
  6. smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9PU40.

Expressioni

Gene expression databases

ExpressionAtlasiQ9PU40. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010566.

Structurei

3D structure databases

ProteinModelPortaliQ9PU40.
SMRiQ9PU40. Positions 153-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG3186.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ9PU40.
KOiK00501.
OrthoDBiEOG7KM5T1.
PhylomeDBiQ9PU40.
TreeFamiTF313327.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE
60 70 80 90 100
AAAAATDAAE STETIVFEEK DGRAMLNLFF MLKGAKTSPL SRALKVFETF
110 120 130 140 150
EAKIHHLETR LSRKPREGTA ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR
160 170 180 190 200
TTKEDKFHWF PRKICELDKC HHLVTKFDPD LDLDHPGYSD QVYRQRRKSI
210 220 230 240 250
AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH ACKEYLEAFN
260 270 280 290 300
LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVAGLLSA RDFLASLAFR
310 320 330 340 350
VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL
360 370 380 390 400
GATDEEIEKL ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE
410 420 430 440 450
PEVRDFDPDA AAVQPYQDQN YQPVYFVSES FSDAKNKLRN YAAHIKRPFS
460 470 480 490
VKYEPYTHSI ELLDSPQTIC HSLESVRDEL HSLINALNVI S
Length:491
Mass (Da):56,016
Last modified:April 30, 2000 - v1
Checksum:i6322F2D58E746930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251387 mRNA. Translation: CAB62388.1.
PIRiS40309.
RefSeqiNP_990136.1. NM_204805.2.
UniGeneiGga.327.

Genome annotation databases

GeneIDi395592.
KEGGigga:395592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251387 mRNA. Translation: CAB62388.1.
PIRiS40309.
RefSeqiNP_990136.1. NM_204805.2.
UniGeneiGga.327.

3D structure databases

ProteinModelPortaliQ9PU40.
SMRiQ9PU40. Positions 153-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010566.

Proteomic databases

PaxDbiQ9PU40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395592.
KEGGigga:395592.

Organism-specific databases

CTDi7054.

Phylogenomic databases

eggNOGiCOG3186.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ9PU40.
KOiK00501.
OrthoDBiEOG7KM5T1.
PhylomeDBiQ9PU40.
TreeFamiTF313327.

Enzyme and pathway databases

ReactomeiREACT_276476. Catecholamine biosynthesis.

Miscellaneous databases

NextBioi20815665.
PROiQ9PU40.

Gene expression databases

ExpressionAtlasiQ9PU40. baseline.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiIPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
[Graphical view]
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiPF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Chicken tyrosine hydroxylase gene: isolation and functional characterization of the 5' flanking region."
    Carrier A., Devignes M.D., Renoir D., Auffray C.
    J. Neurochem. 61:2215-2224(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells."
    Ernsberger U., Patzke H., Tissier-Seta J.P., Reh T., Goridis C., Rohrer H.
    Mech. Dev. 52:125-136(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Ernsberger U.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9PU40_CHICK
AccessioniPrimary (citable) accession number: Q9PU40
Entry historyi
Integrated into UniProtKB/TrEMBL: April 30, 2000
Last sequence update: April 30, 2000
Last modified: March 31, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.