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Protein
Submitted name:

Tyrosine hydroxylase

Gene

tyrosine hydroxylase

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Fe2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi324IronUniRule annotation1
Metal bindingi329IronUniRule annotation1
Metal bindingi369IronUniRule annotation1

GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • iron ion binding Source: InterPro
  • tyrosine 3-monooxygenase activity Source: AgBase

GO - Biological processi

Keywordsi

LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-209905. Catecholamine biosynthesis.

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine hydroxylaseImported
Gene namesi
Name:tyrosine hydroxylaseImported
Synonyms:THImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ9PU40.

Expressioni

Gene expression databases

BgeeiENSGALG00000006551.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 491BH4_AAA_HYDROXYL_2InterPro annotationAdd BLAST347

Phylogenomic databases

eggNOGiKOG3820. Eukaryota.
COG3186. LUCA.
GeneTreeiENSGT00390000010268.
HOGENOMiHOG000233373.
HOVERGENiHBG006841.
InParanoidiQ9PU40.
KOiK00501.
OrthoDBiEOG091G05MZ.
TreeFamiTF313327.

Family and domain databases

Gene3Di1.10.800.10. 1 hit.
InterProiView protein in InterPro
IPR001273. ArAA_hydroxylase.
IPR018301. ArAA_hydroxylase_Fe/CU_BS.
IPR036951. ArAA_hydroxylase_sf.
IPR036329. Aro-AA_hydroxylase_C_sf.
IPR019774. Aromatic-AA_hydroxylase_C.
IPR005962. Tyr_3_mOase.
IPR019773. Tyrosine_3-monooxygenase-like.
IPR021164. Tyrosine_hydroxylase_CS.
PANTHERiPTHR11473. PTHR11473. 1 hit.
PfamiView protein in Pfam
PF00351. Biopterin_H. 1 hit.
PF12549. TOH_N. 2 hits.
PIRSFiPIRSF000336. TH. 1 hit.
PRINTSiPR00372. FYWHYDRXLASE.
SUPFAMiSSF56534. SSF56534. 1 hit.
TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
PROSITEiView protein in PROSITE
PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
PS51410. BH4_AAA_HYDROXYL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE
60 70 80 90 100
AAAAATDAAE STETIVFEEK DGRAMLNLFF MLKGAKTSPL SRALKVFETF
110 120 130 140 150
EAKIHHLETR LSRKPREGTA ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR
160 170 180 190 200
TTKEDKFHWF PRKICELDKC HHLVTKFDPD LDLDHPGYSD QVYRQRRKSI
210 220 230 240 250
AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH ACKEYLEAFN
260 270 280 290 300
LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVAGLLSA RDFLASLAFR
310 320 330 340 350
VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL
360 370 380 390 400
GATDEEIEKL ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE
410 420 430 440 450
PEVRDFDPDA AAVQPYQDQN YQPVYFVSES FSDAKNKLRN YAAHIKRPFS
460 470 480 490
VKYEPYTHSI ELLDSPQTIC HSLESVRDEL HSLINALNVI S
Length:491
Mass (Da):56,016
Last modified:May 1, 2000 - v1
Checksum:i6322F2D58E746930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000238 Genomic DNA. No translation available.
AJ251387 mRNA. Translation: CAB62388.1.
PIRiS40309.
RefSeqiNP_990136.1. NM_204805.2.
UniGeneiGga.327.

Genome annotation databases

EnsembliENSGALT00000074933; ENSGALP00000051175; ENSGALG00000029648.
GeneIDi395592.
KEGGigga:395592.

Similar proteinsi

Entry informationi

Entry nameiQ9PU40_CHICK
AccessioniPrimary (citable) accession number: Q9PU40
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported