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Q9PU40

- Q9PU40_CHICK

UniProt

Q9PU40 - Q9PU40_CHICK

Protein
Submitted name:

Tyrosine hydroxylase

Gene

tyrosine hydroxylase

Organism
Gallus gallus (Chicken)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. tyrosine 3-monooxygenase activity Source: Ensembl

    GO - Biological processi

    1. aromatic amino acid family metabolic process Source: InterPro
    2. dopamine biosynthetic process Source: Ensembl
    3. eating behavior Source: Ensembl
    4. embryonic camera-type eye morphogenesis Source: Ensembl
    5. epinephrine biosynthetic process Source: Ensembl
    6. eye photoreceptor cell development Source: Ensembl
    7. heart development Source: Ensembl
    8. learning Source: Ensembl
    9. locomotory behavior Source: Ensembl
    10. mating behavior Source: Ensembl
    11. memory Source: Ensembl
    12. norepinephrine biosynthetic process Source: Ensembl
    13. regulation of heart contraction Source: Ensembl
    14. response to ethanol Source: Ensembl
    15. response to hypoxia Source: Ensembl
    16. synaptic transmission, dopaminergic Source: Ensembl
    17. visual perception Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tyrosine hydroxylaseImported
    Gene namesi
    Name:tyrosine hydroxylaseImported
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. melanosome membrane Source: Ensembl
    4. nucleus Source: Ensembl
    5. perikaryon Source: Ensembl
    6. smooth endoplasmic reticulum Source: Ensembl

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000010566.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PU40.
    SMRiQ9PU40. Positions 153-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG3186.
    HOGENOMiHOG000233373.
    HOVERGENiHBG006841.
    InParanoidiQ9PU40.
    KOiK00501.
    OMAiELDKCHH.
    OrthoDBiEOG7KM5T1.
    PhylomeDBiQ9PU40.
    TreeFamiTF313327.

    Family and domain databases

    Gene3Di1.10.800.10. 1 hit.
    InterProiIPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005962. Tyr_3_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    IPR021164. Tyrosine_hydroxylase_CS.
    [Graphical view]
    PANTHERiPTHR11473. PTHR11473. 1 hit.
    PfamiPF00351. Biopterin_H. 1 hit.
    PF12549. TOH_N. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000336. TH. 1 hit.
    PRINTSiPR00372. FYWHYDRXLASE.
    SUPFAMiSSF56534. SSF56534. 1 hit.
    TIGRFAMsiTIGR01269. Tyr_3_monoox. 1 hit.
    PROSITEiPS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PU40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE    50
    AAAAATDAAE STETIVFEEK DGRAMLNLFF MLKGAKTSPL SRALKVFETF 100
    EAKIHHLETR LSRKPREGTA ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR 150
    TTKEDKFHWF PRKICELDKC HHLVTKFDPD LDLDHPGYSD QVYRQRRKSI 200
    AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH ACKEYLEAFN 250
    LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVAGLLSA RDFLASLAFR 300
    VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL 350
    GATDEEIEKL ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE 400
    PEVRDFDPDA AAVQPYQDQN YQPVYFVSES FSDAKNKLRN YAAHIKRPFS 450
    VKYEPYTHSI ELLDSPQTIC HSLESVRDEL HSLINALNVI S 491
    Length:491
    Mass (Da):56,016
    Last modified:May 1, 2000 - v1
    Checksum:i6322F2D58E746930
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251387 mRNA. Translation: CAB62388.1.
    PIRiS40309.
    RefSeqiNP_990136.1. NM_204805.1.
    UniGeneiGga.327.

    Genome annotation databases

    GeneIDi395592.
    KEGGigga:395592.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251387 mRNA. Translation: CAB62388.1 .
    PIRi S40309.
    RefSeqi NP_990136.1. NM_204805.1.
    UniGenei Gga.327.

    3D structure databases

    ProteinModelPortali Q9PU40.
    SMRi Q9PU40. Positions 153-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000010566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395592.
    KEGGi gga:395592.

    Organism-specific databases

    CTDi 7054.

    Phylogenomic databases

    eggNOGi COG3186.
    HOGENOMi HOG000233373.
    HOVERGENi HBG006841.
    InParanoidi Q9PU40.
    KOi K00501.
    OMAi ELDKCHH.
    OrthoDBi EOG7KM5T1.
    PhylomeDBi Q9PU40.
    TreeFami TF313327.

    Miscellaneous databases

    NextBioi 20815665.
    PROi Q9PU40.

    Family and domain databases

    Gene3Di 1.10.800.10. 1 hit.
    InterProi IPR001273. ArAA_hydroxylase.
    IPR018301. ArAA_hydroxylase_Fe/CU_BS.
    IPR019774. Aromatic-AA_hydroxylase_C.
    IPR005962. Tyr_3_mOase.
    IPR019773. Tyrosine_3-monooxygenase-like.
    IPR021164. Tyrosine_hydroxylase_CS.
    [Graphical view ]
    PANTHERi PTHR11473. PTHR11473. 1 hit.
    Pfami PF00351. Biopterin_H. 1 hit.
    PF12549. TOH_N. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000336. TH. 1 hit.
    PRINTSi PR00372. FYWHYDRXLASE.
    SUPFAMi SSF56534. SSF56534. 1 hit.
    TIGRFAMsi TIGR01269. Tyr_3_monoox. 1 hit.
    PROSITEi PS00367. BH4_AAA_HYDROXYL_1. 1 hit.
    PS51410. BH4_AAA_HYDROXYL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chicken tyrosine hydroxylase gene: isolation and functional characterization of the 5' flanking region."
      Carrier A., Devignes M.D., Renoir D., Auffray C.
      J. Neurochem. 61:2215-2224(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells."
      Ernsberger U., Patzke H., Tissier-Seta J.P., Reh T., Goridis C., Rohrer H.
      Mech. Dev. 52:125-136(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. Ernsberger U.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9PU40_CHICK
    AccessioniPrimary (citable) accession number: Q9PU40
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)