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Protein
Submitted name:

Tyrosine hydroxylase

Gene

tyrosine hydroxylase

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Fe2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi324IronUniRule annotation1
Metal bindingi329IronUniRule annotation1
Metal bindingi369IronUniRule annotation1

GO - Molecular functioni

  • enzyme binding Source: Ensembl
  • iron ion binding Source: InterPro
  • tyrosine 3-monooxygenase activity Source: AgBase

GO - Biological processi

Keywordsi

LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-209905 Catecholamine biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine hydroxylaseImported
Gene namesi
Name:tyrosine hydroxylaseImported
Synonyms:THImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSGALG00000006551

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 491BH4_AAA_HYDROXYL_2InterPro annotationAdd BLAST347

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili42 – 62Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3820 Eukaryota
COG3186 LUCA
GeneTreeiENSGT00390000010268
HOGENOMiHOG000233373
HOVERGENiHBG006841
InParanoidiQ9PU40
KOiK00501
OrthoDBiEOG091G05MZ
TreeFamiTF313327

Family and domain databases

Gene3Di1.10.800.10, 1 hit
InterProiView protein in InterPro
IPR001273 ArAA_hydroxylase
IPR018301 ArAA_hydroxylase_Fe/CU_BS
IPR036951 ArAA_hydroxylase_sf
IPR036329 Aro-AA_hydroxylase_C_sf
IPR019774 Aromatic-AA_hydroxylase_C
IPR005962 Tyr_3_mOase
IPR019773 Tyrosine_3-monooxygenase-like
IPR021164 Tyrosine_hydroxylase_CS
PANTHERiPTHR11473 PTHR11473, 1 hit
PfamiView protein in Pfam
PF00351 Biopterin_H, 1 hit
PF12549 TOH_N, 2 hits
PIRSFiPIRSF000336 TH, 1 hit
PRINTSiPR00372 FYWHYDRXLASE
SUPFAMiSSF56534 SSF56534, 1 hit
TIGRFAMsiTIGR01269 Tyr_3_monoox, 1 hit
PROSITEiView protein in PROSITE
PS00367 BH4_AAA_HYDROXYL_1, 1 hit
PS51410 BH4_AAA_HYDROXYL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PU40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE
60 70 80 90 100
AAAAATDAAE STETIVFEEK DGRAMLNLFF MLKGAKTSPL SRALKVFETF
110 120 130 140 150
EAKIHHLETR LSRKPREGTA ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR
160 170 180 190 200
TTKEDKFHWF PRKICELDKC HHLVTKFDPD LDLDHPGYSD QVYRQRRKSI
210 220 230 240 250
AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH ACKEYLEAFN
260 270 280 290 300
LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVAGLLSA RDFLASLAFR
310 320 330 340 350
VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL
360 370 380 390 400
GATDEEIEKL ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE
410 420 430 440 450
PEVRDFDPDA AAVQPYQDQN YQPVYFVSES FSDAKNKLRN YAAHIKRPFS
460 470 480 490
VKYEPYTHSI ELLDSPQTIC HSLESVRDEL HSLINALNVI S
Length:491
Mass (Da):56,016
Last modified:May 1, 2000 - v1
Checksum:i6322F2D58E746930
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000238 Genomic DNA No translation available.
AJ251387 mRNA Translation: CAB62388.1
PIRiS40309
RefSeqiNP_990136.1, NM_204805.2
UniGeneiGga.327

Genome annotation databases

EnsembliENSGALT00000074933; ENSGALP00000051175; ENSGALG00000029648
GeneIDi395592
KEGGigga:395592

Similar proteinsi

Entry informationi

Entry nameiQ9PU40_CHICK
AccessioniPrimary (citable) accession number: Q9PU40
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health