Q9PU40 (Q9PU40_CHICK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tyrosine hydroxylase EMBL CAB62388.1

Submitted name:
Uncharacterized protein Ensembl ENSGALP00000010566

Gene names

Name:	tyrosine hydroxylase EMBL CAB62388.1
Synonyms:	TH Ensembl ENSGALP00000010566

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro dopamine biosynthetic process Inferred from electronic annotation. Source: Compara eating behavior Inferred from electronic annotation. Source: Compara embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara epinephrine biosynthetic process Inferred from electronic annotation. Source: Compara eye photoreceptor cell development Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara learning Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara mating behavior Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara norepinephrine biosynthetic process Inferred from electronic annotation. Source: Compara regulation of heart contraction Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara synaptic transmission, dopaminergic Inferred from electronic annotation. Source: Compara visual perception Inferred from electronic annotation. Source: Compara
Cellular_component	axon Inferred from electronic annotation. Source: Compara internal side of plasma membrane Inferred from electronic annotation. Source: Compara melanosome membrane Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara perikaryon Inferred from electronic annotation. Source: Compara smooth endoplasmic reticulum Inferred from electronic annotation. Source: Compara
Molecular_function	iron ion binding Inferred from electronic annotation. Source: InterPro tyrosine 3-monooxygenase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9PU40 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 6322F2D58E746930	FASTA	491	56,016
	10 20 30 40 50 60 MPTPNISTSA AKGFRRAVSE LDSKQAEAIM SPRFIGRRQS LIEDARKERE AAAAATDAAE 70 80 90 100 110 120 STETIVFEEK DGRAMLNLFF MLKGAKTSPL SRALKVFETF EAKIHHLETR LSRKPREGTA 130 140 150 160 170 180 ELEYFVRCEV HSSDLNTFIS SIKRVAEDVR TTKEDKFHWF PRKICELDKC HHLVTKFDPD 190 200 210 220 230 240 LDLDHPGYSD QVYRQRRKSI AEIAFHYKHG DPIPRVEYTA EETATWKEVY STLKSLYPTH 250 260 270 280 290 300 ACKEYLEAFN LLEKFCGYNE NNIPQLEEVS RFLKERTGFQ LRPVAGLLSA RDFLASLAFR 310 320 330 340 350 360 VFQCTQYIRH ASSPMHSPEP DCCHELLGHV PMLADKTFAQ FSQDIGLASL GATDEEIEKL 370 380 390 400 410 420 ATLYWFTVEF GLCRQNGIVK AYGAGLLSSY GELIHSLSDE PEVRDFDPDA AAVQPYQDQN 430 440 450 460 470 480 YQPVYFVSES FSDAKNKLRN YAAHIKRPFS VKYEPYTHSI ELLDSPQTIC HSLESVRDEL 490 HSLINALNVI S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chicken tyrosine hydroxylase gene: isolation and functional characterization of the 5' flanking region." Carrier A., Devignes M.D., Renoir D., Auffray C. J. Neurochem. 61:2215-2224(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The expression of tyrosine hydroxylase and the transcription factors cPhox-2 and Cash-1: evidence for distinct inductive steps in the differentiation of chick sympathetic precursor cells." Ernsberger U., Patzke H., Tissier-Seta J.P., Reh T., Goridis C., Rohrer H. Mech. Dev. 52:125-136(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ernsberger U. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution." International Chicken Genome Sequencing Consortium Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K. Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Red jungle fowl Ensembl ENSGALP00000010566.
[5]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Red jungle fowl Ensembl ENSGALP00000010566.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AADN02030385 Genomic DNA. No translation available. AADN02030386 Genomic DNA. No translation available. AADN02030387 Genomic DNA. No translation available. AJ251387 mRNA. Translation: CAB62388.1.
IPI	IPI00571018.
PIR	S40309.
RefSeq	NP_990136.1. NM_204805.1.
UniGene	Gga.327.
3D structure databases
SMR	Q9PU40. Positions 153-491.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000010566.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000010580; ENSGALP00000010566; ENSGALG00000006551.
GeneID	395592.
KEGG	gga:395592.
Organism-specific databases
CTD	7054.
Phylogenomic databases
eggNOG	COG3186.
GeneTree	ENSGT00390000010268.
HOGENOM	HOG000233373.
HOVERGEN	HBG006841.
InParanoid	Q9PU40.
KO	K00501.
OMA	SELDKCH.
OrthoDB	EOG43N7CM.
Family and domain databases
Gene3D	1.10.800.10. 1 hit.
InterPro	IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005962. Tyr_3_mOase. IPR019773. Tyrosine_3-monooxygenase-like. IPR021164. Tyrosine_hydroxylase_CS. [Graphical view]
PANTHER	PTHR11473. PTHR11473. 1 hit.
Pfam	PF00351. Biopterin_H. 1 hit. PF12549. TOH_N. 2 hits. [Graphical view]
PIRSF	PIRSF000336. TH. 1 hit.
PRINTS	PR00372. FYWHYDRXLASE.
SUPFAM	SSF56534. Aaa_hydroxylase. 1 hit.
TIGRFAMs	TIGR01269. Tyr_3_monoox. 1 hit.
PROSITE	PS00367. BH4_AAA_HYDROXYL_1. 1 hit. PS51410. BH4_AAA_HYDROXYL_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815665.

Entry information

Entry name

Q9PU40_CHICK

Accession

Primary (citable) accession number: Q9PU40

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)