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Protein

Lysophosphatidic acid receptor 1-A

Gene

lpar1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA)(PubMed:11278944). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11278944). Signaling triggers an increase of cytoplasmic Ca2+ levels. Signaling leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape (PubMed:11278944). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of Rac. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Promotes cell proliferation in response to lysophosphatidic acid (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Lysophosphatidic acidBy similarity
Binding sitei212 – 2121Lysophosphatidic acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 1-A
Short name:
LPA receptor 1-A
Short name:
LPA-1-A1 Publication
Alternative name(s):
Lysophosphatidic acid receptor LPA1 homolog 1
Short name:
xLPA1-1
Gene namesi
Name:lpar1-a
Synonyms:lpa1r, lpa1r1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255824. lpar1.

Subcellular locationi

  • Cell surface By similarity
  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Endosome By similarity

  • Note: Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularBy similarityAdd
BLAST
Transmembranei53 – 7725Helical; Name=1By similarityAdd
BLAST
Topological domaini78 – 858CytoplasmicBy similarity
Transmembranei86 – 10924Helical; Name=2By similarityAdd
BLAST
Topological domaini110 – 12314ExtracellularBy similarityAdd
BLAST
Transmembranei124 – 14623Helical; Name=3By similarityAdd
BLAST
Topological domaini147 – 16519CytoplasmicBy similarityAdd
BLAST
Transmembranei166 – 18621Helical; Name=4By similarityAdd
BLAST
Topological domaini187 – 20620ExtracellularBy similarityAdd
BLAST
Transmembranei207 – 22721Helical; Name=5By similarityAdd
BLAST
Topological domaini228 – 25730CytoplasmicBy similarityAdd
BLAST
Transmembranei258 – 28225Helical; Name=6By similarityAdd
BLAST
Topological domaini283 – 29614ExtracellularBy similarityAdd
BLAST
Transmembranei297 – 31721Helical; Name=7By similarityAdd
BLAST
Topological domaini318 – 36649CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Lysophosphatidic acid receptor 1-APRO_0000069704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 192By similarity
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi190 ↔ 197By similarity
Disulfide bondi286 ↔ 289By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed at high levels in oocytes and at lower levels in brain and spinal cord. Below detection level in lung, heart, kidney, liver, muscle, stomach, and intestine.

Structurei

3D structure databases

ProteinModelPortaliQ9PU17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1316Lysophosphatidic acid bindingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG103071.
KOiK04289.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PU17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLSEFVSE PISMMSQTSA ASESQCYYNE TIAFFYNRSG KYLATEWNAV
60 70 80 90 100
SKLVMGLGIT VCIFIMLANL LVMVAIYVNR RFHFPIYYLM ANLAAADFFA
110 120 130 140 150
GLAYFYLMFN TGPNTRRLTV STWLLRQGLI DTSLTASVAN LLAIAIERHI
160 170 180 190 200
TVFRMQLHTR MSNRRVVVVI VVIWTVAIVM GAIPSVGWNC ICDLEQCSNM
210 220 230 240 250
APLYSDSYLI FWTIFNLVTF VVMVVLYAHI FVYVRQKTMR MSRHSSGPRR
260 270 280 290 300
NRDTMMSLLK TVVIVLGAFI VCWTPGLVLL LLDICCPQCN ILAYEKFFLL
310 320 330 340 350
LAEFNSAMNP IIYSYRDKEM SATFKQILCC QRTENVNGPT EGSDRSASSL
360
NHTILAGVHS NDHSVV
Length:366
Mass (Da):41,364
Last modified:May 1, 2000 - v1
Checksum:i2F5661B0D13DCAEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249843 mRNA. Translation: CAB62282.1.
BC049389 mRNA. Translation: AAH49389.1.
RefSeqiNP_001079716.1. NM_001086247.1.
UniGeneiXl.243.

Genome annotation databases

GeneIDi379403.
KEGGixla:379403.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249843 mRNA. Translation: CAB62282.1.
BC049389 mRNA. Translation: AAH49389.1.
RefSeqiNP_001079716.1. NM_001086247.1.
UniGeneiXl.243.

3D structure databases

ProteinModelPortaliQ9PU17.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379403.
KEGGixla:379403.

Organism-specific databases

CTDi379403.
XenbaseiXB-GENE-6255824. lpar1.

Phylogenomic databases

HOVERGENiHBG103071.
KOiK04289.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPA11_XENLA
AccessioniPrimary (citable) accession number: Q9PU17
Secondary accession number(s): Q5D097
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.