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Protein

Frizzled-3

Gene

FZD3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processNeurogenesis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-3
Short name:
Fz-3
Short name:
cFz-3
Gene namesi
Name:FZD3
Synonyms:FZ3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 5CytoplasmicSequence analysis›5
Transmembranei6 – 26Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini27 – 54ExtracellularSequence analysisAdd BLAST28
Transmembranei55 – 75Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini76CytoplasmicSequence analysis›1

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000205976‹1 – ›76Frizzled-3Add BLAST›76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9PTW3.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000026786.

Family & Domainsi

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
HOGENOMiHOG000233237.
InParanoidiQ9PTW3.
PhylomeDBiQ9PTW3.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR026553. FZD3_vertebrates.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF100. PTHR11309:SF100. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PRINTSiPR00489. FRIZZLED.
PROSITEiView protein in PROSITE
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9PTW3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
YPERPIIFYA VCYMMVSLIF FIGFLLEDRV ACNASSPAQY KASTVTQGSH
60 70
NKACTMLFMV LYFFTMAGSV WWVILR
Length:76
Mass (Da):8,747
Last modified:May 1, 2000 - v1
Checksum:i189CB4786B3E2363
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei761

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029450 mRNA. Translation: BAA89400.1.
UniGeneiGga.35578.
Gga.3839.

Entry informationi

Entry nameiFZD3_CHICK
AccessioniPrimary (citable) accession number: Q9PTW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families