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Protein

Frizzled-6

Gene

FZD6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, may be involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Neurogenesis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-6
Short name:
Fz-6
Short name:
cFz-6
Gene namesi
Name:FZD6
Synonyms:FZ6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 89›89ExtracellularSequence analysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini111 – 12111CytoplasmicSequence analysisAdd
BLAST
Transmembranei122 – 14221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini143 – 16927ExtracellularSequence analysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=3Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›190›190Frizzled-6PRO_0000205977Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9PTW1.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025843.

Structurei

3D structure databases

ProteinModelPortaliQ9PTW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 20›20FZPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
InParanoidiQ9PTW1.
KOiK02376.

Family and domain databases

InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM01330. Frizzled. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9PTW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FGFAWPEELE CSRLVNCDET APATAPVTTN AHGTQKTPGQ TRRDYGFWCP
60 70 80 90 100
RHLHTSNGQG YKFLGIDQCA PPCPNMYFKN YELDVAKSFI GIVSIFCLCA
110 120 130 140 150
TLFTFLTFLI DVKRFRYPER PIIYYSVCYS IVSLMYFIGF LLGNRTACNK
160 170 180 190
ADDKLEIGET VVLGSQNKAC TVLFMVLYFF TMAGTIWWVI
Length:190
Mass (Da):21,622
Last modified:May 1, 2000 - v1
Checksum:i99C380C7712688D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei190 – 1901

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029452 mRNA. Translation: BAA89402.1.
RefSeqiNP_001258860.1. NM_001271931.2.
UniGeneiGga.2690.
Gga.54740.

Genome annotation databases

GeneIDi378788.
KEGGigga:378788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029452 mRNA. Translation: BAA89402.1.
RefSeqiNP_001258860.1. NM_001271931.2.
UniGeneiGga.2690.
Gga.54740.

3D structure databases

ProteinModelPortaliQ9PTW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025843.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ9PTW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378788.
KEGGigga:378788.

Organism-specific databases

CTDi8323.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
InParanoidiQ9PTW1.
KOiK02376.

Family and domain databases

InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM01330. Frizzled. 1 hit.
[Graphical view]
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression of the frizzled family involved in Wnt signaling during chick limb development."
    Nohno T., Kawakami Y., Wada N., Komaguchi C., Nishimatsu S.
    Cell. Mol. Biol. 45:653-659(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Limb bud.

Entry informationi

Entry nameiFZD6_CHICK
AccessioniPrimary (citable) accession number: Q9PTW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.