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Q9PTP2

- AXNR_XENLA

UniProt

Q9PTP2 - AXNR_XENLA

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Protein
Axin-related protein
Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. signal transducer activity Source: InterPro

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. regulation of Wnt signaling pathway Source: UniProtKB
  4. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-related protein
Short name:
xARP
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252887. xarp.

Subcellular locationi

Cytoplasm. Cytoplasmic vesicle 1 Publication

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. cytoplasmic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Axin-related protein
PRO_0000286587Add
BLAST

Expressioni

Developmental stagei

Expressed maternally.1 Publication

Interactioni

Subunit structurei

Interacts with dvl2/dsh via DIX domains in both proteins. Forms a complex with ctnnb1/beta-catenin and gsk3b. Also forms heterodimers with mouse Axin1.1 Publication

Protein-protein interaction databases

MINTiMINT-100845.

Structurei

3D structure databases

ProteinModelPortaliQ9PTP2.
SMRiQ9PTP2. Positions 625-705.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 191120RGS
Add
BLAST
Domaini624 – 70683DIX
Add
BLAST

Sequence similaritiesi

Contains 1 DIX domain.
Contains 1 RGS domain.

Phylogenomic databases

HOVERGENiHBG004324.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PTP2-1 [UniParc]FASTAAdd to Basket

« Hide

MSSAGVLTCI PDSGPIFRET SLRPPVPGQE TNNFKPEKFT MDSQHLKHKE    50
DFNREAEGCV AHDSRFSRWG RSLNLLLDDQ DGATLFRMYL EGEGLGDLLT 100
FWFACNGFRA MDPLEPKTSK TAKAIYRWYV QNSSAVSGRL KPTTRTQVKE 150
CVKNHQLNKT VFDQAQQEIQ RAMEQEAFTS FLQSDICKEY ARGVEDSPTP 200
ESPGPGLPTL TEDEEFGGLH HFSSGMGKIN RAFSRIPPRN QRSHFRKLEQ 250
TYQYFAPAAS INDSEISSDA LTEDSMSMTD GSVDGIPPYR SKKQREIHRS 300
VSANGKVSLP FVPRTMRPPA EMMPTSPAEF AAKLTIALEK VKKQRDAEEK 350
LEEKLQRLKE EEEIADYDIP SSSHETVPGA ALEDDPQSIL DDHVSRVLKT 400
PANLSPRSQS PFVQRKGKFQ PAFSKGQTST SCHLRPKVPQ GMEATSTLAS 450
ELRSSVSSQL PRSSRKPEGC TQPHRPEEGT SAAVLTTPLS PEQEAERNHS 500
VLQWVLDSAK LMKKHHRETA SVTPCPELKK ATHRAASQPA HLFLQDTSMP 550
PLTAPNTLDQ LEEARRRLVE DKRVPKLHKS RCVQSTTLKE KGKTAESVPS 600
SGFSTLKLSE EQKTAKKPSS ECPGQGLAIV YYFCGERIPY MIRTKEPSLT 650
LQEFKELLSK KGSNKYYFKK ESHEFECNAV FQEVSEEDAV LPLFEEKIIC 700
KVERAC 706
Length:706
Mass (Da):79,196
Last modified:May 1, 2000 - v1
Checksum:iC3D0AF0D9540F162
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140243 mRNA. Translation: AAF22574.1.
RefSeqiNP_001079086.1. NM_001085617.1.
UniGeneiXl.610.

Genome annotation databases

GeneIDi373619.
KEGGixla:373619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140243 mRNA. Translation: AAF22574.1 .
RefSeqi NP_001079086.1. NM_001085617.1.
UniGenei Xl.610.

3D structure databases

ProteinModelPortali Q9PTP2.
SMRi Q9PTP2. Positions 625-705.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-100845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 373619.
KEGGi xla:373619.

Organism-specific databases

CTDi 373619.
Xenbasei XB-GENE-6252887. xarp.

Phylogenomic databases

HOVERGENi HBG004324.

Family and domain databases

Gene3Di 1.10.196.10. 2 hits.
InterProi IPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR01301. RGSPROTEIN.
SMARTi SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction."
    Itoh K., Antipova A., Ratcliffe M.J., Sokol S.Y.
    Mol. Cell. Biol. 20:2228-2238(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AXIN1 AND DVL2, IDENTIFICATION IN A COMPLEX WITH CTNNB1 AND GSK3B, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Tissue: Ovary.

Entry informationi

Entry nameiAXNR_XENLA
AccessioniPrimary (citable) accession number: Q9PTP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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