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Protein

Axin-related protein

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.1 Publication

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-related protein
Short name:
xARP
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252887 axin2

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865871 – 706Axin-related proteinAdd BLAST706

Proteomic databases

PRIDEiQ9PTP2

Expressioni

Developmental stagei

Expressed maternally.1 Publication

Interactioni

Subunit structurei

Interacts with dvl2/dsh via DIX domains in both proteins. Forms a complex with ctnnb1/beta-catenin and gsk3b. Also forms heterodimers with mouse Axin1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9PTP2
SMRiQ9PTP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 191RGSPROSITE-ProRule annotationAdd BLAST120
Domaini624 – 706DIXPROSITE-ProRule annotationAdd BLAST83

Phylogenomic databases

HOVERGENiHBG004324
KOiK04385

Family and domain databases

Gene3Di1.10.196.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR014936 Axin_b-cat-bd
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR016137 RGS
IPR036305 RGS_sf
IPR024066 RGS_subdom1/3
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08833 Axin_b-cat_bind, 1 hit
PF00778 DIX, 1 hit
PF00615 RGS, 1 hit
PRINTSiPR01301 RGSPROTEIN
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00315 RGS, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50841 DIX, 1 hit
PS50132 RGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PTP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAGVLTCI PDSGPIFRET SLRPPVPGQE TNNFKPEKFT MDSQHLKHKE
60 70 80 90 100
DFNREAEGCV AHDSRFSRWG RSLNLLLDDQ DGATLFRMYL EGEGLGDLLT
110 120 130 140 150
FWFACNGFRA MDPLEPKTSK TAKAIYRWYV QNSSAVSGRL KPTTRTQVKE
160 170 180 190 200
CVKNHQLNKT VFDQAQQEIQ RAMEQEAFTS FLQSDICKEY ARGVEDSPTP
210 220 230 240 250
ESPGPGLPTL TEDEEFGGLH HFSSGMGKIN RAFSRIPPRN QRSHFRKLEQ
260 270 280 290 300
TYQYFAPAAS INDSEISSDA LTEDSMSMTD GSVDGIPPYR SKKQREIHRS
310 320 330 340 350
VSANGKVSLP FVPRTMRPPA EMMPTSPAEF AAKLTIALEK VKKQRDAEEK
360 370 380 390 400
LEEKLQRLKE EEEIADYDIP SSSHETVPGA ALEDDPQSIL DDHVSRVLKT
410 420 430 440 450
PANLSPRSQS PFVQRKGKFQ PAFSKGQTST SCHLRPKVPQ GMEATSTLAS
460 470 480 490 500
ELRSSVSSQL PRSSRKPEGC TQPHRPEEGT SAAVLTTPLS PEQEAERNHS
510 520 530 540 550
VLQWVLDSAK LMKKHHRETA SVTPCPELKK ATHRAASQPA HLFLQDTSMP
560 570 580 590 600
PLTAPNTLDQ LEEARRRLVE DKRVPKLHKS RCVQSTTLKE KGKTAESVPS
610 620 630 640 650
SGFSTLKLSE EQKTAKKPSS ECPGQGLAIV YYFCGERIPY MIRTKEPSLT
660 670 680 690 700
LQEFKELLSK KGSNKYYFKK ESHEFECNAV FQEVSEEDAV LPLFEEKIIC

KVERAC
Length:706
Mass (Da):79,196
Last modified:May 1, 2000 - v1
Checksum:iC3D0AF0D9540F162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140243 mRNA Translation: AAF22574.1
RefSeqiNP_001079086.1, NM_001085617.1
UniGeneiXl.610

Genome annotation databases

GeneIDi373619
KEGGixla:373619

Entry informationi

Entry nameiAXNR_XENLA
AccessioniPrimary (citable) accession number: Q9PTP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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