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Q9PTP2

- AXNR_XENLA

UniProt

Q9PTP2 - AXNR_XENLA

Protein

Axin-related protein

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of Wnt signaling pathway Source: UniProtKB
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro
    4. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-related protein
    Short name:
    xARP
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6252887. xarp.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmic vesicle 1 Publication

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 706706Axin-related proteinPRO_0000286587Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed maternally.1 Publication

    Interactioni

    Subunit structurei

    Interacts with dvl2/dsh via DIX domains in both proteins. Forms a complex with ctnnb1/beta-catenin and gsk3b. Also forms heterodimers with mouse Axin1.1 Publication

    Protein-protein interaction databases

    MINTiMINT-100845.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PTP2.
    SMRiQ9PTP2. Positions 625-705.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini72 – 191120RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini624 – 70683DIXPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG004324.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PTP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAGVLTCI PDSGPIFRET SLRPPVPGQE TNNFKPEKFT MDSQHLKHKE    50
    DFNREAEGCV AHDSRFSRWG RSLNLLLDDQ DGATLFRMYL EGEGLGDLLT 100
    FWFACNGFRA MDPLEPKTSK TAKAIYRWYV QNSSAVSGRL KPTTRTQVKE 150
    CVKNHQLNKT VFDQAQQEIQ RAMEQEAFTS FLQSDICKEY ARGVEDSPTP 200
    ESPGPGLPTL TEDEEFGGLH HFSSGMGKIN RAFSRIPPRN QRSHFRKLEQ 250
    TYQYFAPAAS INDSEISSDA LTEDSMSMTD GSVDGIPPYR SKKQREIHRS 300
    VSANGKVSLP FVPRTMRPPA EMMPTSPAEF AAKLTIALEK VKKQRDAEEK 350
    LEEKLQRLKE EEEIADYDIP SSSHETVPGA ALEDDPQSIL DDHVSRVLKT 400
    PANLSPRSQS PFVQRKGKFQ PAFSKGQTST SCHLRPKVPQ GMEATSTLAS 450
    ELRSSVSSQL PRSSRKPEGC TQPHRPEEGT SAAVLTTPLS PEQEAERNHS 500
    VLQWVLDSAK LMKKHHRETA SVTPCPELKK ATHRAASQPA HLFLQDTSMP 550
    PLTAPNTLDQ LEEARRRLVE DKRVPKLHKS RCVQSTTLKE KGKTAESVPS 600
    SGFSTLKLSE EQKTAKKPSS ECPGQGLAIV YYFCGERIPY MIRTKEPSLT 650
    LQEFKELLSK KGSNKYYFKK ESHEFECNAV FQEVSEEDAV LPLFEEKIIC 700
    KVERAC 706
    Length:706
    Mass (Da):79,196
    Last modified:May 1, 2000 - v1
    Checksum:iC3D0AF0D9540F162
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140243 mRNA. Translation: AAF22574.1.
    RefSeqiNP_001079086.1. NM_001085617.1.
    UniGeneiXl.610.

    Genome annotation databases

    GeneIDi373619.
    KEGGixla:373619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140243 mRNA. Translation: AAF22574.1 .
    RefSeqi NP_001079086.1. NM_001085617.1.
    UniGenei Xl.610.

    3D structure databases

    ProteinModelPortali Q9PTP2.
    SMRi Q9PTP2. Positions 625-705.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-100845.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 373619.
    KEGGi xla:373619.

    Organism-specific databases

    CTDi 373619.
    Xenbasei XB-GENE-6252887. xarp.

    Phylogenomic databases

    HOVERGENi HBG004324.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction."
      Itoh K., Antipova A., Ratcliffe M.J., Sokol S.Y.
      Mol. Cell. Biol. 20:2228-2238(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AXIN1 AND DVL2, IDENTIFICATION IN A COMPLEX WITH CTNNB1 AND GSK3B, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
      Tissue: OvaryImported.

    Entry informationi

    Entry nameiAXNR_XENLA
    AccessioniPrimary (citable) accession number: Q9PTP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3