Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Axin-related protein

Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates the wnt signaling pathway by interacting with dvl2/dsh, which displaces gsk3b from the axnr-gsk3b complex and thus prevents degradation of ctnnb1/beta-catenin.1 Publication

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of Wnt signaling pathway Source: UniProtKB
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-related protein
Short name:
xARP
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252887. xarp.

Subcellular locationi

Cytoplasm 1 Publication. Cytoplasmic vesicle 1 Publication

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. cytoplasmic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Axin-related proteinPRO_0000286587Add
BLAST

Expressioni

Developmental stagei

Expressed maternally.1 Publication

Interactioni

Subunit structurei

Interacts with dvl2/dsh via DIX domains in both proteins. Forms a complex with ctnnb1/beta-catenin and gsk3b. Also forms heterodimers with mouse Axin1.1 Publication

Protein-protein interaction databases

MINTiMINT-100845.

Structurei

3D structure databases

ProteinModelPortaliQ9PTP2.
SMRiQ9PTP2. Positions 625-705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 191120RGSPROSITE-ProRule annotationAdd
BLAST
Domaini624 – 70683DIXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG004324.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PTP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAGVLTCI PDSGPIFRET SLRPPVPGQE TNNFKPEKFT MDSQHLKHKE
60 70 80 90 100
DFNREAEGCV AHDSRFSRWG RSLNLLLDDQ DGATLFRMYL EGEGLGDLLT
110 120 130 140 150
FWFACNGFRA MDPLEPKTSK TAKAIYRWYV QNSSAVSGRL KPTTRTQVKE
160 170 180 190 200
CVKNHQLNKT VFDQAQQEIQ RAMEQEAFTS FLQSDICKEY ARGVEDSPTP
210 220 230 240 250
ESPGPGLPTL TEDEEFGGLH HFSSGMGKIN RAFSRIPPRN QRSHFRKLEQ
260 270 280 290 300
TYQYFAPAAS INDSEISSDA LTEDSMSMTD GSVDGIPPYR SKKQREIHRS
310 320 330 340 350
VSANGKVSLP FVPRTMRPPA EMMPTSPAEF AAKLTIALEK VKKQRDAEEK
360 370 380 390 400
LEEKLQRLKE EEEIADYDIP SSSHETVPGA ALEDDPQSIL DDHVSRVLKT
410 420 430 440 450
PANLSPRSQS PFVQRKGKFQ PAFSKGQTST SCHLRPKVPQ GMEATSTLAS
460 470 480 490 500
ELRSSVSSQL PRSSRKPEGC TQPHRPEEGT SAAVLTTPLS PEQEAERNHS
510 520 530 540 550
VLQWVLDSAK LMKKHHRETA SVTPCPELKK ATHRAASQPA HLFLQDTSMP
560 570 580 590 600
PLTAPNTLDQ LEEARRRLVE DKRVPKLHKS RCVQSTTLKE KGKTAESVPS
610 620 630 640 650
SGFSTLKLSE EQKTAKKPSS ECPGQGLAIV YYFCGERIPY MIRTKEPSLT
660 670 680 690 700
LQEFKELLSK KGSNKYYFKK ESHEFECNAV FQEVSEEDAV LPLFEEKIIC

KVERAC
Length:706
Mass (Da):79,196
Last modified:May 1, 2000 - v1
Checksum:iC3D0AF0D9540F162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140243 mRNA. Translation: AAF22574.1.
RefSeqiNP_001079086.1. NM_001085617.1.
UniGeneiXl.610.

Genome annotation databases

GeneIDi373619.
KEGGixla:373619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140243 mRNA. Translation: AAF22574.1.
RefSeqiNP_001079086.1. NM_001085617.1.
UniGeneiXl.610.

3D structure databases

ProteinModelPortaliQ9PTP2.
SMRiQ9PTP2. Positions 625-705.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-100845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373619.
KEGGixla:373619.

Organism-specific databases

CTDi373619.
XenbaseiXB-GENE-6252887. xarp.

Phylogenomic databases

HOVERGENiHBG004324.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction."
    Itoh K., Antipova A., Ratcliffe M.J., Sokol S.Y.
    Mol. Cell. Biol. 20:2228-2238(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH AXIN1 AND DVL2, IDENTIFICATION IN A COMPLEX WITH CTNNB1 AND GSK3B, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
    Tissue: OvaryImported.

Entry informationi

Entry nameiAXNR_XENLA
AccessioniPrimary (citable) accession number: Q9PTP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.