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Q9PTH3

- IBP2A_DANRE

UniProt

Q9PTH3 - IBP2A_DANRE

Protein

Insulin-like growth factor-binding protein 2-A

Gene

igfbp2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.2 Publications

    GO - Molecular functioni

    1. insulin-like growth factor I binding Source: UniProtKB
    2. insulin-like growth factor II binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: ZFIN
    2. growth Source: ZFIN
    3. heart development Source: ZFIN
    4. negative regulation of cell proliferation Source: UniProtKB
    5. negative regulation of developmental growth Source: UniProtKB
    6. negative regulation of DNA replication Source: UniProtKB
    7. regulation of cell growth Source: InterPro
    8. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Growth regulation

    Keywords - Ligandi

    Growth factor binding

    Protein family/group databases

    MEROPSiI31.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulin-like growth factor-binding protein 2-A
    Short name:
    IGF-binding protein 2-A
    Short name:
    IGFBP-2-A
    Short name:
    IGFBP-2a
    Gene namesi
    Name:igfbp2a
    Synonyms:igfbp2, igfbp2b
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 6

    Organism-specific databases

    ZFINiZDB-GENE-000125-12. igfbp2a.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 276254Insulin-like growth factor-binding protein 2-APRO_0000014376Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi180 ↔ 214PROSITE-ProRule annotation
    Disulfide bondi225 ↔ 236PROSITE-ProRule annotation
    Disulfide bondi238 ↔ 259PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    In embryos at 24 hpf, initially expressed in the lens and cranial region, and at 48 and 72 hpf in the brain boundary vasculature. Expression in these regions persists throughout the hatching period and by 96 hpf expression is most abundant in the liver. In both male and female adults, highest expression is in the liver with modest expression in the brain. In male but not females adults, expressed at a low level in muscle and gonad. Also expressed in the adult intestine.2 Publications

    Developmental stagei

    Not expressed until 10 hpf. Expression gradually increases from 10 to 36 hpf and is maintained at high levels thereafter.1 Publication

    Inductioni

    Expression increases in response to prolonged fasting but decreases in response to growth hormone (GH).1 Publication

    Gene expression databases

    BgeeiQ9PTH3.

    Interactioni

    Subunit structurei

    Interacts equally well with igf1 and igf2.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PTH3.
    SMRiQ9PTH3. Positions 26-103, 172-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 10582IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini177 – 25983Thyroglobulin type-1PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi254 – 2563Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47500.
    GeneTreeiENSGT00550000074457.
    HOGENOMiHOG000253012.
    InParanoidiQ9PTH3.
    OMAiGAGTCEK.
    OrthoDBiEOG74N5HG.
    PhylomeDBiQ9PTH3.
    TreeFamiTF331211.

    Family and domain databases

    Gene3Di4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProiIPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view]
    PANTHERiPTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    PfamiPF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view]
    PRINTSiPR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTiSM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEiPS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9PTH3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSYVSCGLL LALVTFHGTA RSEMVFRCPS CTAERQAACP MLTETCGEIV    50
    REPGCGCCPV CARQEGEQCG VYTPRCSSGL RCYPKPDSEL PLELLVQGLG 100
    RCGRKVDTEP TGSAEPREVS GEVQDPLDIG LTEVPPIRKP TKDSPWKESA 150
    VLQHRQQLKS KMKYHKVEDP KAPHAKQSQC QQELDQVLER ISKITFKDNR 200
    TPLEDLYSLH IPNCDKRGQY NLKQCKMSVN GYRGECWCVN PHTGRPMPTS 250
    PLIRGDPNCN QYLDGQEMDP SVDPPN 276
    Length:276
    Mass (Da):30,764
    Last modified:May 1, 2000 - v1
    Checksum:i37AB561B7C9947D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198033 mRNA. Translation: AAF23123.1.
    BC056331 mRNA. Translation: AAH56331.1.
    BC153606 mRNA. Translation: AAI53607.1.
    RefSeqiNP_571533.1. NM_131458.2.
    UniGeneiDr.78120.

    Genome annotation databases

    EnsembliENSDART00000074327; ENSDARP00000068816; ENSDARG00000052470.
    GeneIDi794176.
    KEGGidre:794176.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF198033 mRNA. Translation: AAF23123.1 .
    BC056331 mRNA. Translation: AAH56331.1 .
    BC153606 mRNA. Translation: AAI53607.1 .
    RefSeqi NP_571533.1. NM_131458.2.
    UniGenei Dr.78120.

    3D structure databases

    ProteinModelPortali Q9PTH3.
    SMRi Q9PTH3. Positions 26-103, 172-267.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I31.953.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000074327 ; ENSDARP00000068816 ; ENSDARG00000052470 .
    GeneIDi 794176.
    KEGGi dre:794176.

    Organism-specific databases

    CTDi 794176.
    ZFINi ZDB-GENE-000125-12. igfbp2a.

    Phylogenomic databases

    eggNOGi NOG47500.
    GeneTreei ENSGT00550000074457.
    HOGENOMi HOG000253012.
    InParanoidi Q9PTH3.
    OMAi GAGTCEK.
    OrthoDBi EOG74N5HG.
    PhylomeDBi Q9PTH3.
    TreeFami TF331211.

    Miscellaneous databases

    NextBioi 20931744.

    Gene expression databases

    Bgeei Q9PTH3.

    Family and domain databases

    Gene3Di 4.10.40.20. 1 hit.
    4.10.800.10. 1 hit.
    InterProi IPR009030. Growth_fac_rcpt_N_dom.
    IPR012210. IGFBP-2.
    IPR000867. IGFBP-like.
    IPR009168. IGFBP1-6.
    IPR022321. IGFBP_1-6_chordata.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000716. Thyroglobulin_1.
    [Graphical view ]
    PANTHERi PTHR11551. PTHR11551. 1 hit.
    PTHR11551:SF5. PTHR11551:SF5. 1 hit.
    Pfami PF00219. IGFBP. 1 hit.
    PF00086. Thyroglobulin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01976. IGFBPFAMILY.
    PR01978. IGFBPFAMILY2.
    SMARTi SM00121. IB. 1 hit.
    SM00211. TY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57610. SSF57610. 1 hit.
    PROSITEi PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS00484. THYROGLOBULIN_1_1. 1 hit.
    PS51162. THYROGLOBULIN_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish."
      Duan C., Ding J., Li Q., Tsai W., Pozios K.
      Proc. Natl. Acad. Sci. U.S.A. 96:15274-15279(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IGF1 AND IGF2, TISSUE SPECIFICITY, INDUCTION.
    2. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
      Zhou J., Li W., Kamei H., Duan C.
      PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiIBP2A_DANRE
    AccessioniPrimary (citable) accession number: Q9PTH3
    Secondary accession number(s): A8E5I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3