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Q9PTH3 (IBP2A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Insulin-like growth factor-binding protein 2-A

Short name=IGF-binding protein 2-A
Short name=IGFBP-2-A
Short name=IGFBP-2a
Gene names
Name:igfbp2a
Synonyms:igfbp2, igfbp2b
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Ref.1 Ref.3

Subunit structure

Interacts equally well with igf1 and igf2. Ref.1

Subcellular location

Secreted.

Tissue specificity

In embryos at 24 hpf, initially expressed in the lens and cranial region, and at 48 and 72 hpf in the brain boundary vasculature. Expression in these regions persists throughout the hatching period and by 96 hpf expression is most abundant in the liver. In both male and female adults, highest expression is in the liver with modest expression in the brain. In male but not females adults, expressed at a low level in muscle and gonad. Also expressed in the adult intestine. Ref.1 Ref.3

Developmental stage

Not expressed until 10 hpf. Expression gradually increases from 10 to 36 hpf and is maintained at high levels thereafter. Ref.3

Induction

Expression increases in response to prolonged fasting but decreases in response to growth hormone (GH). Ref.1

Sequence similarities

Contains 1 IGFBP N-terminal domain.

Contains 1 thyroglobulin type-1 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 276254Insulin-like growth factor-binding protein 2-A
PRO_0000014376

Regions

Domain24 – 10582IGFBP N-terminal
Domain177 – 25983Thyroglobulin type-1
Motif254 – 2563Cell attachment site Potential

Amino acid modifications

Disulfide bond180 ↔ 214 By similarity
Disulfide bond225 ↔ 236 By similarity
Disulfide bond238 ↔ 259 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PTH3 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 37AB561B7C9947D7

FASTA27630,764
        10         20         30         40         50         60 
MLSYVSCGLL LALVTFHGTA RSEMVFRCPS CTAERQAACP MLTETCGEIV REPGCGCCPV 

        70         80         90        100        110        120 
CARQEGEQCG VYTPRCSSGL RCYPKPDSEL PLELLVQGLG RCGRKVDTEP TGSAEPREVS 

       130        140        150        160        170        180 
GEVQDPLDIG LTEVPPIRKP TKDSPWKESA VLQHRQQLKS KMKYHKVEDP KAPHAKQSQC 

       190        200        210        220        230        240 
QQELDQVLER ISKITFKDNR TPLEDLYSLH IPNCDKRGQY NLKQCKMSVN GYRGECWCVN 

       250        260        270 
PHTGRPMPTS PLIRGDPNCN QYLDGQEMDP SVDPPN 

« Hide

References

« Hide 'large scale' references
[1]"Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish."
Duan C., Ding J., Li Q., Tsai W., Pozios K.
Proc. Natl. Acad. Sci. U.S.A. 96:15274-15279(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH IGF1 AND IGF2, TISSUE SPECIFICITY, INDUCTION.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]"Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence."
Zhou J., Li W., Kamei H., Duan C.
PLoS ONE 3:E3926-E3926(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF198033 mRNA. Translation: AAF23123.1.
BC056331 mRNA. Translation: AAH56331.1.
BC153606 mRNA. Translation: AAI53607.1.
RefSeqNP_571533.1. NM_131458.2.
UniGeneDr.78120.

3D structure databases

ProteinModelPortalQ9PTH3.
SMRQ9PTH3. Positions 26-103, 172-267.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI31.953.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000074327; ENSDARP00000068816; ENSDARG00000052470.
GeneID794176.
KEGGdre:794176.

Organism-specific databases

CTD794176.
ZFINZDB-GENE-000125-12. igfbp2a.

Phylogenomic databases

eggNOGNOG47500.
GeneTreeENSGT00550000074457.
HOGENOMHOG000253012.
InParanoidQ9PTH3.
OMAGAGTCEK.
OrthoDBEOG74N5HG.
PhylomeDBQ9PTH3.
TreeFamTF331211.

Gene expression databases

BgeeQ9PTH3.

Family and domain databases

Gene3D4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20931744.

Entry information

Entry nameIBP2A_DANRE
AccessionPrimary (citable) accession number: Q9PTH3
Secondary accession number(s): A8E5I5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families