Reviewed, UniProtKB/Swiss-Prot Q9PT92 (CATA_DANRE)

Names and origin

Protein names

Recommended name:
    Catalase
    EC=1.11.1.6

Gene names

Name:

cat

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group By similarity. NADP By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding NADP
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to copper ion Inferred from direct assay. Source: ZFIN
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Catalase		PRO_0000084906
Sites
	Active site	75	1	By similarity
	Active site	148	1	By similarity
	Metal binding	358	1	Iron (heme axial ligand) By similarity
Experimental info
	Sequence conflict	110	1	V → A in AAF89686. Ref.2
	Sequence conflict	123	1	P → S in AAF89686. Ref.2
	Sequence conflict	152	1	T → I in AAF89686. Ref.2
	Sequence conflict	161	1	S → F in AAF89686. Ref.2
	Sequence conflict	350 – 352	3	MLQ → NAA in AAF89686. Ref.2
	Sequence conflict	478	1	M → T in AAF89686. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9PT92-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E1120D3796522785	FASTA	526	59,654
	10 20 30 40 50 60 MADDREKSTD QMKLWKEGRG SQRPDVLTTG AGVPIGDKLN AMTAGPRGPL LVQDVVFTDE 70 80 90 100 110 120 MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF EHVGKTTPIV VRFSTVAGEA 130 140 150 160 170 180 GSPDTVRDPR GFAVKFYTDE GNWDLTGNNT PTFFIRDTLL SPSFIHSQKR NPQTHLKDPD 190 200 210 220 230 240 MVWDFWSLRP ESLHQVSFLF SDRGIPDGYR HMNGYGSHTF KLVNAQGQPV YCKFHYKTNQ 250 260 270 280 290 300 GIKNIPVEEA DRLAATDPDY SIRDLYNAIA NGNFPSWTFY IQVMTFEQAE NWKWNPFDLT 310 320 330 340 350 360 KVWSHKEFPL IPVGRFVLNR NPVNYFAEVE QLAFDPSNMP PGIEPSPDKM LQGRLFSYPD 370 380 390 400 410 420 THRHRLGANY LQLPVNCPYR TRVANYQRDG PMCMHDNQGG APNYYPNSFS APDVQPRFLE 430 440 450 460 470 480 SKCKVSPDVA RYNSADDDNV TQVRTFFTQV LNEAERERLC QNMAGHLKGA QLFIQKRMVQ 490 500 510 520 NLMAVHSDYG NRVQALLDKH NAEGKKNTVH VYSRGGASAV AAASKM

References

[1]	"Cloning and expression of a cDNA coding for catalase from zebrafish (Danio rerio)." Ken C.F., Lin C.T., Wu J.L., Shaw J.F. J. Agric. Food Chem. 48:2092-2096(2000) [PubMed: 10888504] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and sequence analysis of the Danio rerio catalase gene." Gerhard G.S., Kauffman E.J., Grundy M.A. Comp. Biochem. Physiol. 127B:447-457(2000) [PubMed: 11281262] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ007505 mRNA. Translation: CAB64949.1. AF170069 mRNA. Translation: AAF89686.1.
IPI	IPI00511689.
UniGene	Dr.1079
3D structure databases
HSSP	HSSP built from PDB template 4BLC based on UniProtKB P00432.
SMR	Q9PT92. Positions 5-501.
ModBase	Search...
Proteomic databases
PRIDE	Q9PT92.
Genome annotation databases
Ensembl	ENSDARG00000004909. Danio rerio. [Contig view]
Organism-specific databases
ZFIN	ZDB-GENE-000210-20. cat.
Phylogenomic databases
HOGENOM	Q9PT92.
HOVERGEN	Q9PT92.
Enzyme and pathway databases
BRENDA	1.11.1.6. 96826.
Gene expression databases
ArrayExpress	Q9PT92.
Bgee	Q9PT92.
Family and domain databases
InterPro	IPR002226. Catalase. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
ProDom	PD000510. Catalase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_DANRE

Accession

Primary (citable) accession number: Q9PT92
Secondary accession number(s): Q9I8V5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project