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Q9PT92

- CATA_DANRE

UniProt

Q9PT92 - CATA_DANRE

Protein

Catalase

Gene

cat

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

    Cofactori

    Heme group.By similarity
    NADP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei75 – 751PROSITE-ProRule annotation
    Active sitei148 – 1481PROSITE-ProRule annotation
    Metal bindingi358 – 3581Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW
    2. response to copper ion Source: ZFIN

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase (EC:1.11.1.6)
    Gene namesi
    Name:cat
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-000210-20. cat.

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526CatalasePRO_0000084906Add
    BLAST

    Proteomic databases

    PRIDEiQ9PT92.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PT92.
    SMRiQ9PT92. Positions 25-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Phylogenomic databases

    eggNOGiCOG0753.
    HOGENOMiHOG000087852.
    HOVERGENiHBG003986.
    InParanoidiQ9PT92.
    PhylomeDBiQ9PT92.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PT92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDREKSTD QMKLWKEGRG SQRPDVLTTG AGVPIGDKLN AMTAGPRGPL    50
    LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITRYSKAKVF 100
    EHVGKTTPIV VRFSTVAGEA GSPDTVRDPR GFAVKFYTDE GNWDLTGNNT 150
    PTFFIRDTLL SPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF 200
    SDRGIPDGYR HMNGYGSHTF KLVNAQGQPV YCKFHYKTNQ GIKNIPVEEA 250
    DRLAATDPDY SIRDLYNAIA NGNFPSWTFY IQVMTFEQAE NWKWNPFDLT 300
    KVWSHKEFPL IPVGRFVLNR NPVNYFAEVE QLAFDPSNMP PGIEPSPDKM 350
    LQGRLFSYPD THRHRLGANY LQLPVNCPYR TRVANYQRDG PMCMHDNQGG 400
    APNYYPNSFS APDVQPRFLE SKCKVSPDVA RYNSADDDNV TQVRTFFTQV 450
    LNEAERERLC QNMAGHLKGA QLFIQKRMVQ NLMAVHSDYG NRVQALLDKH 500
    NAEGKKNTVH VYSRGGASAV AAASKM 526
    Length:526
    Mass (Da):59,654
    Last modified:May 1, 2000 - v1
    Checksum:iE1120D3796522785
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101V → A in AAF89686. (PubMed:11281262)Curated
    Sequence conflicti123 – 1231P → S in AAF89686. (PubMed:11281262)Curated
    Sequence conflicti152 – 1521T → I in AAF89686. (PubMed:11281262)Curated
    Sequence conflicti161 – 1611S → F in AAF89686. (PubMed:11281262)Curated
    Sequence conflicti350 – 3523MLQ → NAA in AAF89686. (PubMed:11281262)Curated
    Sequence conflicti478 – 4781M → T in AAF89686. (PubMed:11281262)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007505 mRNA. Translation: CAB64949.1.
    AF170069 mRNA. Translation: AAF89686.1.
    UniGeneiDr.1079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007505 mRNA. Translation: CAB64949.1 .
    AF170069 mRNA. Translation: AAF89686.1 .
    UniGenei Dr.1079.

    3D structure databases

    ProteinModelPortali Q9PT92.
    SMRi Q9PT92. Positions 25-503.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9PT92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ZFINi ZDB-GENE-000210-20. cat.

    Phylogenomic databases

    eggNOGi COG0753.
    HOGENOMi HOG000087852.
    HOVERGENi HBG003986.
    InParanoidi Q9PT92.
    PhylomeDBi Q9PT92.

    Miscellaneous databases

    PROi Q9PT92.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cDNA coding for catalase from zebrafish (Danio rerio)."
      Ken C.F., Lin C.T., Wu J.L., Shaw J.F.
      J. Agric. Food Chem. 48:2092-2096(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning and sequence analysis of the Danio rerio catalase gene."
      Gerhard G.S., Kauffman E.J., Grundy M.A.
      Comp. Biochem. Physiol. 127B:447-457(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCATA_DANRE
    AccessioniPrimary (citable) accession number: Q9PT92
    Secondary accession number(s): Q9I8V5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3