Q9PSX7 (RHOC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho-related GTP-binding protein RhoC

Gene names

Name:	RHOC
Synonyms:	ARHC

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cleavage furrow By similarity. Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner By similarity.
Developmental stage	Detected in embryonic notochord. Ref.1
Sequence similarities	Belongs to the small GTPase superfamily. Rho family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	ADP-ribosylation Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apical junction assembly Inferred from sequence or structural similarity. Source: UniProtKB cell cycle cytokinesis Inferred from sequence or structural similarity. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cleavage furrow Inferred from sequence or structural similarity. Source: UniProtKB intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Rho-related GTP-binding protein RhoC		PRO_0000276771
	Propeptide	191 – 193	3	Removed in mature form By similarity		PRO_0000276772
Regions
	Nucleotide binding	12 – 19	8	GTP By similarity
	Nucleotide binding	59 – 63	5	GTP By similarity
	Nucleotide binding	117 – 120	4	GTP By similarity
	Motif	34 – 42	9	Effector region Potential
Amino acid modifications
	Modified residue	41	1	ADP-ribosylasparagine; by botulinum toxin By similarity
	Modified residue	190	1	Cysteine methyl ester By similarity
	Lipidation	190	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PSX7 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 358E9BD3AE3813A6	FASTA	193	21,973
	10 20 30 40 50 60 MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT 70 80 90 100 110 120 AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 130 140 150 160 170 180 LRNDEHTRRE LAKMKQEPVK PEEGRDMANR INAFGYLECS AKTKEGVREV FEMATRAGLQ 190 VRKNKKRRGC PLL

References

[1]	"A role for rhoB in the delamination of neural crest cells from the dorsal neural tube." Liu J.-P., Jessell T.M. Development 125:5055-5067(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ADP-RIBOSYLATION, DEVELOPMENTAL STAGE. Strain: Hamburger-Hamilton. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF098514 mRNA. Translation: AAD12256.1.
IPI	IPI00590423.
RefSeq	NP_001025020.1. NM_001029849.1.
UniGene	Gga.17535.
3D structure databases
HSSP	HSSP built from PDB template 1CXZ based on UniProtKB P61586.
ProteinModelPortal	Q9PSX7.
SMR	Q9PSX7. Positions 2-180.
ModBase	Search...
Proteomic databases
PaxDb	Q9PSX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395869.
KEGG	gga:395869.
Organism-specific databases
CTD	389.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000233974.
HOVERGEN	HBG009351.
InParanoid	Q9PSX7.
KO	K07857.
OrthoDB	EOG4G4GRD.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003578. Small_GTPase_Rho. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815936.

Entry information

Entry name

RHOC_CHICK

Accession

Primary (citable) accession number: Q9PSX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	May 1, 2000
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program