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Q9PSX7

- RHOC_CHICK

UniProt

Q9PSX7 - RHOC_CHICK

Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi59 – 635GTPBy similarity
    Nucleotide bindingi117 – 1204GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. signal transducer activity Source: Ensembl

    GO - Biological processi

    1. apical junction assembly Source: UniProtKB
    2. cytokinesis Source: UniProtKB
    3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho-related GTP-binding protein RhoC
    Gene namesi
    Name:RHOC
    Synonyms:ARHC
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 26

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated. Cleavage furrow By similarity
    Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.By similarity

    GO - Cellular componenti

    1. cleavage furrow Source: UniProtKB
    2. nucleus Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Rho-related GTP-binding protein RhoCPRO_0000276771Add
    BLAST
    Propeptidei191 – 1933Removed in mature formBy similarityPRO_0000276772

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411ADP-ribosylasparagine; by botulinum toxinBy similarity
    Modified residuei190 – 1901Cysteine methyl esterBy similarity
    Lipidationi190 – 1901S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    ADP-ribosylation, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ9PSX7.
    PRIDEiQ9PSX7.

    Expressioni

    Developmental stagei

    Detected in embryonic notochord.1 Publication

    Structurei

    Secondary structure

    1
    193
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi64 – 674

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YF6X-ray2.80C60-69[»]
    ProteinModelPortaliQ9PSX7.
    SMRiQ9PSX7. Positions 2-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 429Effector regionSequence Analysis

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00700000104143.
    HOGENOMiHOG000233974.
    HOVERGENiHBG009351.
    InParanoidiQ9PSX7.
    KOiK07857.
    PhylomeDBiQ9PSX7.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9PSX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG    50
    KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT 100
    PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR 150
    INAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKKRRGC PLL 193
    Length:193
    Mass (Da):21,973
    Last modified:May 1, 2000 - v1
    Checksum:i358E9BD3AE3813A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098514 mRNA. Translation: AAD12256.1.
    RefSeqiNP_001025020.1. NM_001029849.1.
    UniGeneiGga.17535.

    Genome annotation databases

    EnsembliENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
    GeneIDi395869.
    KEGGigga:395869.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF098514 mRNA. Translation: AAD12256.1 .
    RefSeqi NP_001025020.1. NM_001029849.1.
    UniGenei Gga.17535.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YF6 X-ray 2.80 C 60-69 [» ]
    ProteinModelPortali Q9PSX7.
    SMRi Q9PSX7. Positions 2-180.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9PSX7.
    PRIDEi Q9PSX7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000002385 ; ENSGALP00000002383 ; ENSGALG00000001569 .
    GeneIDi 395869.
    KEGGi gga:395869.

    Organism-specific databases

    CTDi 389.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00700000104143.
    HOGENOMi HOG000233974.
    HOVERGENi HBG009351.
    InParanoidi Q9PSX7.
    KOi K07857.
    PhylomeDBi Q9PSX7.

    Miscellaneous databases

    NextBioi 20815936.
    PROi Q9PSX7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube."
      Liu J.-P., Jessell T.M.
      Development 125:5055-5067(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ADP-RIBOSYLATION, DEVELOPMENTAL STAGE.
      Strain: Hamburger-Hamilton.
      Tissue: Embryo.

    Entry informationi

    Entry nameiRHOC_CHICK
    AccessioniPrimary (citable) accession number: Q9PSX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3