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Q9PSX7 (RHOC_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rho-related GTP-binding protein RhoC
Gene names
Name:RHOC
Synonyms:ARHC
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Cleavage furrow By similarity. Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner By similarity.

Developmental stage

Detected in embryonic notochord. Ref.1

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Rho-related GTP-binding protein RhoC
PRO_0000276771
Propeptide191 – 1933Removed in mature form By similarity
PRO_0000276772

Regions

Nucleotide binding12 – 198GTP By similarity
Nucleotide binding59 – 635GTP By similarity
Nucleotide binding117 – 1204GTP By similarity
Motif34 – 429Effector region Potential

Amino acid modifications

Modified residue411ADP-ribosylasparagine; by botulinum toxin By similarity
Modified residue1901Cysteine methyl ester By similarity
Lipidation1901S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PSX7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 358E9BD3AE3813A6

FASTA19321,973
        10         20         30         40         50         60 
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG KQVELALWDT 

        70         80         90        100        110        120 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 

       130        140        150        160        170        180 
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR INAFGYLECS AKTKEGVREV FEMATRAGLQ 

       190 
VRKNKKRRGC PLL 

« Hide

References

[1]"A role for rhoB in the delamination of neural crest cells from the dorsal neural tube."
Liu J.-P., Jessell T.M.
Development 125:5055-5067(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ADP-RIBOSYLATION, DEVELOPMENTAL STAGE.
Strain: Hamburger-Hamilton.
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF098514 mRNA. Translation: AAD12256.1.
RefSeqNP_001025020.1. NM_001029849.1.
UniGeneGga.17535.

3D structure databases

ProteinModelPortalQ9PSX7.
SMRQ9PSX7. Positions 2-180.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9PSX7.
PRIDEQ9PSX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
GeneID395869.
KEGGgga:395869.

Organism-specific databases

CTD389.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00700000104143.
HOGENOMHOG000233974.
HOVERGENHBG009351.
InParanoidQ9PSX7.
KOK07857.
PhylomeDBQ9PSX7.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815936.
PROQ9PSX7.

Entry information

Entry nameRHOC_CHICK
AccessionPrimary (citable) accession number: Q9PSX7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families