Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi59 – 63GTPBy similarity5
Nucleotide bindingi117 – 120GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-194840. Rho GTPase cycle.
R-GGA-416482. G alpha (12/13) signalling events.
R-GGA-416572. Sema4D induced cell migration and growth-cone collapse.
R-GGA-5625740. RHO GTPases activate PKNs.
R-GGA-5625900. RHO GTPases activate CIT.
R-GGA-5627117. RHO GTPases Activate ROCKs.
R-GGA-5663220. RHO GTPases Activate Formins.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Gene namesi
Name:RHOC
Synonyms:ARHC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002767711 – 190Rho-related GTP-binding protein RhoCAdd BLAST190
PropeptideiPRO_0000276772191 – 193Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41ADP-ribosylasparagine; by botulinum toxinBy similarity1
Modified residuei190Cysteine methyl esterBy similarity1
Lipidationi190S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9PSX7.

Expressioni

Developmental stagei

Detected in embryonic notochord.1 Publication

Gene expression databases

BgeeiENSGALG00000001569.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039370.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi64 – 67Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0BX-ray2.80C60-69[»]
ProteinModelPortaliQ9PSX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ9PSX7.
KOiK07857.
OMAiKRRGACQ.
OrthoDBiEOG091G0QVS.
PhylomeDBiQ9PSX7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PSX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR
160 170 180 190
INAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKKRRGC PLL
Length:193
Mass (Da):21,973
Last modified:May 1, 2000 - v1
Checksum:i358E9BD3AE3813A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098514 mRNA. Translation: AAD12256.1.
RefSeqiNP_001025020.1. NM_001029849.1.
UniGeneiGga.17535.

Genome annotation databases

EnsembliENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
GeneIDi395869.
KEGGigga:395869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098514 mRNA. Translation: AAD12256.1.
RefSeqiNP_001025020.1. NM_001029849.1.
UniGeneiGga.17535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4D0BX-ray2.80C60-69[»]
ProteinModelPortaliQ9PSX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039370.

Proteomic databases

PaxDbiQ9PSX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
GeneIDi395869.
KEGGigga:395869.

Organism-specific databases

CTDi389.

Phylogenomic databases

eggNOGiKOG0393. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ9PSX7.
KOiK07857.
OMAiKRRGACQ.
OrthoDBiEOG091G0QVS.
PhylomeDBiQ9PSX7.

Enzyme and pathway databases

ReactomeiR-GGA-194840. Rho GTPase cycle.
R-GGA-416482. G alpha (12/13) signalling events.
R-GGA-416572. Sema4D induced cell migration and growth-cone collapse.
R-GGA-5625740. RHO GTPases activate PKNs.
R-GGA-5625900. RHO GTPases activate CIT.
R-GGA-5627117. RHO GTPases Activate ROCKs.
R-GGA-5663220. RHO GTPases Activate Formins.

Miscellaneous databases

PROiQ9PSX7.

Gene expression databases

BgeeiENSGALG00000001569.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHOC_CHICK
AccessioniPrimary (citable) accession number: Q9PSX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.