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Q9PSX7

- RHOC_CHICK

UniProt

Q9PSX7 - RHOC_CHICK

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Protein
Rho-related GTP-binding protein RhoC
Gene
RHOC, ARHC
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTP By similarity
Nucleotide bindingi59 – 635GTP By similarity
Nucleotide bindingi117 – 1204GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. signal transducer activity Source: Ensembl

GO - Biological processi

  1. apical junction assembly Source: UniProtKB
  2. cytokinesis Source: UniProtKB
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Gene namesi
Name:RHOC
Synonyms:ARHC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 26

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side Reviewed prediction. Cleavage furrow By similarity
Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner By similarity.

GO - Cellular componenti

  1. cleavage furrow Source: UniProtKB
  2. nucleus Source: Ensembl
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Rho-related GTP-binding protein RhoC
PRO_0000276771Add
BLAST
Propeptidei191 – 1933Removed in mature form By similarity
PRO_0000276772

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411ADP-ribosylasparagine; by botulinum toxin By similarity
Modified residuei190 – 1901Cysteine methyl ester By similarity
Lipidationi190 – 1901S-geranylgeranyl cysteine By similarity

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9PSX7.
PRIDEiQ9PSX7.

Expressioni

Developmental stagei

Detected in embryonic notochord.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi64 – 674

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YF6X-ray2.80C60-69[»]
ProteinModelPortaliQ9PSX7.
SMRiQ9PSX7. Positions 2-180.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 429Effector region Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00700000104143.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ9PSX7.
KOiK07857.
PhylomeDBiQ9PSX7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PSX7-1 [UniParc]FASTAAdd to Basket

« Hide

MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG    50
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT 100
PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR 150
INAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKKRRGC PLL 193
Length:193
Mass (Da):21,973
Last modified:May 1, 2000 - v1
Checksum:i358E9BD3AE3813A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098514 mRNA. Translation: AAD12256.1.
RefSeqiNP_001025020.1. NM_001029849.1.
UniGeneiGga.17535.

Genome annotation databases

EnsembliENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
GeneIDi395869.
KEGGigga:395869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF098514 mRNA. Translation: AAD12256.1 .
RefSeqi NP_001025020.1. NM_001029849.1.
UniGenei Gga.17535.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YF6 X-ray 2.80 C 60-69 [» ]
ProteinModelPortali Q9PSX7.
SMRi Q9PSX7. Positions 2-180.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9PSX7.
PRIDEi Q9PSX7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000002385 ; ENSGALP00000002383 ; ENSGALG00000001569 .
GeneIDi 395869.
KEGGi gga:395869.

Organism-specific databases

CTDi 389.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00700000104143.
HOGENOMi HOG000233974.
HOVERGENi HBG009351.
InParanoidi Q9PSX7.
KOi K07857.
PhylomeDBi Q9PSX7.

Miscellaneous databases

NextBioi 20815936.
PROi Q9PSX7.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube."
    Liu J.-P., Jessell T.M.
    Development 125:5055-5067(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ADP-RIBOSYLATION, DEVELOPMENTAL STAGE.
    Strain: Hamburger-Hamilton.
    Tissue: Embryo.

Entry informationi

Entry nameiRHOC_CHICK
AccessioniPrimary (citable) accession number: Q9PSX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi