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Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPBy similarity
Nucleotide bindingi59 – 635GTPBy similarity
Nucleotide bindingi117 – 1204GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. signal transducer activity Source: Ensembl

GO - Biological processi

  1. apical junction assembly Source: UniProtKB
  2. cytokinesis Source: UniProtKB
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  4. skeletal muscle satellite cell migration Source: AgBase
  5. small GTPase mediated signal transduction Source: InterPro
  6. wound healing, spreading of cells Source: AgBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_320693. G alpha (12/13) signalling events.
REACT_334706. Rho GTPase cycle.
REACT_338894. Sema4D induced cell migration and growth-cone collapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Gene namesi
Name:RHOC
Synonyms:ARHC
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 26

Subcellular locationi

  1. Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
  2. Cleavage furrow By similarity

  3. Note: Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.By similarity

GO - Cellular componenti

  1. cleavage furrow Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Rho-related GTP-binding protein RhoCPRO_0000276771Add
BLAST
Propeptidei191 – 1933Removed in mature formBy similarityPRO_0000276772

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411ADP-ribosylasparagine; by botulinum toxinBy similarity
Modified residuei190 – 1901Cysteine methyl esterBy similarity
Lipidationi190 – 1901S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

ADP-ribosylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9PSX7.
PRIDEiQ9PSX7.

Expressioni

Developmental stagei

Detected in embryonic notochord.1 Publication

Structurei

Secondary structure

1
193
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi64 – 674Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YF6X-ray2.80C60-69[»]
ProteinModelPortaliQ9PSX7.
SMRiQ9PSX7. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi34 – 429Effector regionSequence Analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ9PSX7.
KOiK07857.
OMAiKKRKGCP.
PhylomeDBiQ9PSX7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PSX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR
160 170 180 190
INAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKKRRGC PLL
Length:193
Mass (Da):21,973
Last modified:May 1, 2000 - v1
Checksum:i358E9BD3AE3813A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098514 mRNA. Translation: AAD12256.1.
RefSeqiNP_001025020.1. NM_001029849.1.
UniGeneiGga.17535.

Genome annotation databases

EnsembliENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
GeneIDi395869.
KEGGigga:395869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098514 mRNA. Translation: AAD12256.1.
RefSeqiNP_001025020.1. NM_001029849.1.
UniGeneiGga.17535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YF6X-ray2.80C60-69[»]
ProteinModelPortaliQ9PSX7.
SMRiQ9PSX7. Positions 2-180.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9PSX7.
PRIDEiQ9PSX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002385; ENSGALP00000002383; ENSGALG00000001569.
GeneIDi395869.
KEGGigga:395869.

Organism-specific databases

CTDi389.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000119020.
HOGENOMiHOG000233974.
HOVERGENiHBG009351.
InParanoidiQ9PSX7.
KOiK07857.
OMAiKKRKGCP.
PhylomeDBiQ9PSX7.

Enzyme and pathway databases

ReactomeiREACT_320693. G alpha (12/13) signalling events.
REACT_334706. Rho GTPase cycle.
REACT_338894. Sema4D induced cell migration and growth-cone collapse.

Miscellaneous databases

NextBioi20815936.
PROiQ9PSX7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A role for rhoB in the delamination of neural crest cells from the dorsal neural tube."
    Liu J.-P., Jessell T.M.
    Development 125:5055-5067(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ADP-RIBOSYLATION, DEVELOPMENTAL STAGE.
    Strain: Hamburger-Hamilton.
    Tissue: Embryo.

Entry informationi

Entry nameiRHOC_CHICK
AccessioniPrimary (citable) accession number: Q9PSX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 1, 2000
Last modified: April 1, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.