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Protein

Cytochrome P450

Gene

CYP1A3

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases.UniRule annotation

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.UniRule annotation

Cofactori

hemeUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • oxidative deethylation Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.1UniRule annotation)
Gene namesi
Name:CYP1A3Imported
Synonyms:cyp1a3Imported
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)Imported
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation

GO - Cellular componenti

  • basal plasma membrane Source: AgBase
  • cell Source: AgBase
  • cytoplasm Source: AgBase
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • microvillus membrane Source: AgBase
  • nuclear heterochromatin Source: AgBase
  • nuclear membrane Source: AgBase
  • perinuclear region of cytoplasm Source: AgBase
  • rough endoplasmic reticulum Source: AgBase
  • smooth endoplasmic reticulum Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, MicrosomeUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PRH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMILPIIG SVSASEGLVA MVTLCLVYMI MKYMHTEIPE GLKRLPGPKP
60 70 80 90 100
LPIIGNVLEV HNNPHLSLTA MSERYGSVFQ IQIGMRPVVV LSGSETVRQA
110 120 130 140 150
LIKQGEDFAG RPDLYSFKFI NDGKSLAFST DKAGVWRARR KLAMSALRSF
160 170 180 190 200
ATLEGSTPEY SCALEEHVCK EGEYLVKQLT SVMDVSGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYSHDDQELL GLVNMSDEFG QVVGSGNPAD FIPILRYLPN
260 270 280 290 300
RTMKRFMDIN DRFNTFVQKI VSEHYDSYDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENANVQVSDE KIVGIVNDLF GAGFDTISTA LSWAVVYLVA YPEIQERLHQ
360 370 380 390 400
ELKEKVGMIR TPRLSDKINL PLLEAFILEI FRHSSFLPFT IPHCTVKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQVN HDPELWKEPS SFNPDRFLSA DGTELNKLEG
460 470 480 490 500
EKVLVFGMGK RRCIGEAIGR NEVYLFLAIL LQRLCFQEKP GHPLDMTPEY
510 520
GLTMKHKRCQ LKASLRPWGQ EE
Length:522
Mass (Da):59,086
Last modified:May 1, 2000 - v1
Checksum:iAF36786EB19D73DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059710 Genomic DNA. Translation: AAD45966.1.
AF059711 mRNA. Translation: AAD45967.1.
RefSeqiNP_001118226.1. NM_001124754.1.
UniGeneiOmy.11738.

Genome annotation databases

GeneIDi100142632.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF059710 Genomic DNA. Translation: AAD45966.1.
AF059711 mRNA. Translation: AAD45967.1.
RefSeqiNP_001118226.1. NM_001124754.1.
UniGeneiOmy.11738.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100142632.

Organism-specific databases

CTDi100142632.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Trout cyp1a3 gene: recognition of fish DNA motifs by mouse regulatory proteins."
    Carvan M.J.III., Ponomareva L.V., Solis W.A., Matlib R.S., Puga A., Nebert D.W.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. "Trout CYP1A3 Gene: Recognition of Fish DNA Motifs by Mouse Regulatory Proteins."
    Carvan M.J.III., Ponomareva L.V., Solis W.A., Matlib R.S., Puga A., Nebert D.W.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ9PRH3_ONCMY
AccessioniPrimary (citable) accession number: Q9PRH3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.