Q9PRC5 (KTHY_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	UU020

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.
Sequence caution	The sequence AAF30425.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Thymidylate kinase HAMAP MF_00165		PRO_0000155366
Regions
	Nucleotide binding	23 – 30	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9PRC5 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: FE93B27E19635B3D	FASTA	230	26,900
	10 20 30 40 50 60 MILTKNSNEK KPLKKGLFIV FEGIDGAGKT SILKQLLEVL KEPKLVNKIF LTREPGGKNN 70 80 90 100 110 120 NAAEMIREFF LKNLEVFDPL TLAYLYASSR AEHVKKTINP HLEKDHIVIS DRFVHSSYIY 130 140 150 160 170 180 QGIVQNQSLD VIYQINQQAI GELEIDYVFY FDVNVNNALN RMKNRFDNTN AFDSQNKQFY 190 200 210 220 230 EKLLKQYPSV FKVYNQPKKI IFIDANKNEN EVLCEVKEQL LKIFKEHKYI

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30425.1. Different initiation.
PIR	H82944.
RefSeq	NP_077850.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PRC5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875806.
GenomeReviews	Gene locus UU020 in contig AF222894_GR.
KEGG	uur:UU020.
PATRIC	20533556. VBIUrePar45146_0020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG626009.
OMA	SENTFPD.
ProtClustDB	CLSK2298742.
Enzyme and pathway databases
BioCyc	UURE95667:UU020-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_UREPA

Accession

Primary (citable) accession number: Q9PRC5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program