Q9PR71 (TRXB_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin reductase
Short name=TRXR
EC=1.8.1.9

Gene names

Name:	trxB
Ordered Locus Names:	UU074

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Redox-active center
Ligand	FAD Flavoprotein NADP
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro thioredoxin-disulfide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Thioredoxin reductase		PRO_0000166755
Regions
	Nucleotide binding	35 – 42	8	FAD By similarity
	Nucleotide binding	277 – 286	10	FAD By similarity
Amino acid modifications
	Disulfide bond	134 ↔ 137		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PR71 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CC01383CD53CB8A4	FASTA	309	34,150
	10 20 30 40 50 60 MNQEVYDLVI IGAGPAGLAA AVYAKRSGLN VIIVEKQFPG GKIALTSNVE NYLGINSIPG 70 80 90 100 110 120 PELAYKMYEQ VLNLNVSIIY EAADEISLKE KYKKIKLTTQ TLITKTVIIA TGTENRRLNI 130 140 150 160 170 180 LGELEFENKG ISYCAICDGP LYKNKAVSVI GSGNSAVEEA IYLATIAKEV HLIANKPQFK 190 200 210 220 230 240 AEQQLVQIAN NTPNIKIYYN KQTFEFFGHQ FLEGLKFRDL ITNEVTTLNI EANFTFIGLL 250 260 270 280 290 300 PSRINTNNLC IFNEVNGFIT TDKNMQTSVC GIFAAGDIVD KNVRQIATAT NDGVIAALYA KEYITRNNW

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30479.1.
RefSeq	NP_077904.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PR71.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876144.
GenomeReviews	Gene locus UU074 in contig AF222894_GR.
KEGG	uur:UU074.
PATRIC	20533668. VBIUrePar45146_0076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG669726.
OMA	RTSICAT.
ProtClustDB	CLSK2298762.
Enzyme and pathway databases
BioCyc	UURE95667:UU074-MONOMER.
Family and domain databases
InterPro	IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR001327. Pyr_OxRdtase_NAD-bd_dom. IPR000103. Pyridine_nuc-diS_OxRdtase_2. [Graphical view]
KO	K00384.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR. PR00469. PNDRDTASEII.
PROSITE	PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRXB_UREPA

Accession

Primary (citable) accession number: Q9PR71

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program