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Q9PR12 (ATPA_UREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene names
Name:atpA
Ordered Locus Names:UU132
OrganismUreaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]
Taxonomic identifier273119 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 799799ATP synthase subunit alpha HAMAP MF_01346
PRO_0000238393

Regions

Nucleotide binding170 – 1778ATP By similarity
Region1 – 549549ATP synthase alpha chain HAMAP MF_01346
Region550 – 799250Unknown HAMAP MF_01346

Sites

Site3631Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PR12 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1A63E0F5C8982C8B

FASTA79989,447
        10         20         30         40         50         60 
MTDNKNHSLI SDIKSQIKKF SEKALTLEVG NVISLGDGIV LVDGLDNVML NEIVRFENGV 

        70         80         90        100        110        120 
EGMALNLEED AVGVVLLGDY SNIKEGDRVY RTKRIVEVPV GDVMLGRVVD ALGKAVDNKG 

       130        140        150        160        170        180 
NIVANKFSVI EKIAPGVMDR KSVHQPLETG ILSIDAMFPI GKGQRELIIG DRQTGKTTIA 

       190        200        210        220        230        240 
IDAIINQKGR NVNCVYVAIG QKNSTIANVV RELEAHGAME YTTVVTANAS ELPALQYIAP 

       250        260        270        280        290        300 
FTGVTIAEEW MHQGKDVLIV YDDLSKHAIA YRTLSLLLRR PPGREAYPGD VFYLHSRLLE 

       310        320        330        340        350        360 
RACKLKDELG AGSITALPII ETQAGDISAY IPTNVISITD GQIFMMTSLF NAGQRPAIDA 

       370        380        390        400        410        420 
GQSVSRVGSA AQIKSVKQTG ASLKLELANY RELEAFSQFG SDLDDETKRI LKLGKAVMAV 

       430        440        450        460        470        480 
IKQAPNKPYN QTDEAIILFT VKEKLIPQVP VERIQDFKEY LLNYFKGTKL RADLEDKKAF 

       490        500        510        520        530        540 
DKENTPAFRC AIQKAINSFL NNSQDFKPCE EAEQTAFDKF FNENESIVVD GENDFNFINE 

       550        560        570        580        590        600 
EVSLKPTTET SEAVQIEEKV QDFVEPQEIL ETNKMEENHI FEEVEPEKII CEHHEFEIAE 

       610        620        630        640        650        660 
NQEKIEGQQV LEDTNHEYSI YETVEQSGEV DNDESKDDDL EVLVPVAEIE HDEAILDERE 

       670        680        690        700        710        720 
NRNWVFSDSA VSEVEKQTIM ISISSNEAEQ LFDNAKSVVF FKVTPKYPVE KVLVYVTSPV 

       730        740        750        760        770        780 
QKVVGEFDLL KIDVNSVNTS WNKYRSSSVI SSRKEYLEYF NSHKEAHALL ASKVYKYRKP 

       790 
KDLASFNMNK GPSGFTYLK

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References

[1]"The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
Nature 407:757-762(2000) [PubMed: 11048724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700970.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF222894 Genomic DNA. Translation: AAF30538.1.
RefSeqNP_077963.1. NC_002162.1.

3D structure databases

ProteinModelPortalQ9PR12.
SMRQ9PR12. Positions 28-469.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID875853.
GenomeReviewsGene locus UU132 in contig AF222894_GR.
KEGGuur:UU132.
PATRIC20533800. VBIUrePar45146_0138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG565875.
OMAYGHISEG.
ProtClustDBCLSK2559603.

Enzyme and pathway databases

BioCycUURE95667:UU132-MONOMER.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact. Fused.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR004100. ATPase_F1/V1/A1-cplx_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA_UREPA
AccessionPrimary (citable) accession number: Q9PR12
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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