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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140L-tryptophanUniRule annotation1
Binding sitei191ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi152 – 154ATPUniRule annotation3
Nucleotide bindingi200 – 204ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:UU175
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000000423 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367041 – 333Tryptophan--tRNA ligaseAdd BLAST333

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273119.UU175

Structurei

3D structure databases

ProteinModelPortaliQ9PQW8
SMRiQ9PQW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi200 – 204"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PQW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLISGIQP TNNLTLGNYL GAIKNFVDLQ DDYEVFLFVA DLHSLTPNIF
60 70 80 90 100
DNTDFSTTKR QIIATYLAAG IDPKKTCLFY QSDILSIPLL AHILLCSTSI
110 120 130 140 150
GELTRMTQFK DKSIKATKMA NNTEMIPSGL LTYPTLMAAD ILTFNADVVP
160 170 180 190 200
VGQDQKQHLE LTRTLADRFN KRYGNTFKLP QVYIPKIGAK IMDLLDPNIK
210 220 230 240 250
MSKSSKNLKG VIFLNDSKDI IFKKIKGALT DNLNKVKYDL TLQPGVSNLM
260 270 280 290 300
TIYACLTNLS FKEIELKYQQ QNYGVFKNDL ANIVADFLEK LQQKISYWLN
310 320 330
SPELDIMIDN SCERANDIAY QNVQLVLKHM QLK
Length:333
Mass (Da):37,755
Last modified:October 1, 2000 - v1
Checksum:iAE6646EB161797FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA Translation: AAF30582.1
RefSeqiWP_006688883.1, NC_002162.1

Genome annotation databases

EnsemblBacteriaiAAF30582; AAF30582; UU175
GeneIDi29672759
KEGGiuur:UU175

Similar proteinsi

Entry informationi

Entry nameiSYW_UREPA
AccessioniPrimary (citable) accession number: Q9PQW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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