Q9PQW6 (PPNK_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	UU177

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120685

Sequences

	Sequence		Length	Mass (Da)
	Q9PQW6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E130EBA81798C731	FASTA	270	31,358
	10 20 30 40 50 60 MKNNKPICFY DIYCFKPQEC FKRNDINLLE DKLKRYSKIT FLRNKENPEI IFLLGGDGSF 70 80 90 100 110 120 INFINQQWKK NVKIVGINYG QLGFYSSYDS IKTINLDEII DENMYYNPLL LKVSINNQNF 130 140 150 160 170 180 FYCLNELSLF SNELVSFDIS INDYPYEKFR GSGLLFVTPS GSTGKNKTAF GPIIFNNHEN 190 200 210 220 230 240 FIMTEIFPVN HLKYSSLNAP VVFRKDYKIS LTNIKFKKSF SVAIDGNIIN FSDKINDIKV 250 260 270 ETIQASSKIH GLNNFKKYID KLNKSFIKGE

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30584.1.
RefSeq	NP_078009.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQW6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875810.
GenomeReviews	Gene locus UU177 in contig AF222894_GR.
KEGG	uur:UU177.
PATRIC	20533896. VBIUrePar45146_0184.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734371.
OMA	EMANAME.
ProtClustDB	CLSK2298813.
Enzyme and pathway databases
BioCyc	UURE95667:UU177-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_UREPA

Accession

Primary (citable) accession number: Q9PQW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program