Q9PQW1 (GPMI_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=iPGM
EC=5.4.2.1

Gene names

Name:	gpmI
Synonyms:	pgm
Ordered Locus Names:	UU182

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01038
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01038
Cofactor	Binds 2 manganese ions per subunit By similarity. HAMAP MF_01038
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01038
Subunit structure	Monomer By similarity. HAMAP MF_01038
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	manganese ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01038		PRO_0000212225
Sites
	Active site	63	1	Phosphoserine intermediate By similarity
	Metal binding	13	1	Manganese 2 By similarity
	Metal binding	63	1	Manganese 2 By similarity
	Metal binding	389	1	Manganese 1 By similarity
	Metal binding	393	1	Manganese 1 By similarity
	Metal binding	430	1	Manganese 2 By similarity
	Metal binding	431	1	Manganese 2 By similarity
	Metal binding	448	1	Manganese 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PQW1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CBC67422051F28D9	FASTA	502	57,393
	10 20 30 40 50 60 MKLNKKIGLI IIDGLGIGKE DNTNAVHLAN PPTLNYLINN FPTLQISAAQ QNIGLLENQA 70 80 90 100 110 120 GNSEIGHLTI GAGRIILNDN ANINNYMKSV DYESAVLSNI KNEIVHIVGM YSNGLVHSNY 130 140 150 160 170 180 EHIHWIIKQI IKNNNQVVLH LISDGRDDYP YGFAQFIEQI NALKKQYNII VKSLSGRYFA 190 200 210 220 230 240 MDRDQRWERT QKAFNAMFVK QDKICEKTFL EVAQSIANSY KSDEFVQPVV FNDDEKYNLK 250 260 270 280 290 300 PHQKVILANY RSDRMRQLAH LLKPNKKFHY NNPFLVQDVN LITLVPFPDV DAIALFEKQN 310 320 330 340 350 360 LNNTLGDVFN KHQIKEARIA ETEKYAHISF FFDGGVNKYY STKTQYLIPS QKVATYDLCP 370 380 390 400 410 420 QMSAHLITKT IIDHYFDHDV FIVNYANPDM VGHSGNMQQT IEAILSVDHE IRKLYDFFEK 430 440 450 460 470 480 NNGVLMITGD HGNAEMMLDD QKQVITSHSV NDVWFIITDN KVILNSTQKF SLANIAPTIL 490 500 EYLNIAQPIQ MTATSMIKKI CE

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30589.1.
RefSeq	NP_078014.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQW1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876207.
GenomeReviews	Gene locus UU182 in contig AF222894_GR.
KEGG	uur:UU182.
PATRIC	20533906. VBIUrePar45146_0189.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG613255.
OMA	DHGNAEL.
ProtClustDB	PRK05434.
Enzyme and pathway databases
BioCyc	UURE95667:UU182-MONOMER.
Family and domain databases
HAMAP	MF_01038. GpmI. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR011258. BPG-indep_PGM_N. IPR006124. Metalloenzyme. IPR005995. Pgm_bpd_ind. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits. G3DSA:3.40.1450.10. BPG-indep_PGM_N. 1 hit.
KO	K15633.
Pfam	PF06415. iPGM_N. 1 hit. PF01676. Metalloenzyme. 1 hit. [Graphical view]
PIRSF	PIRSF001492. IPGAM. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit. SSF64158. BPG-indep_PGM_N. 1 hit.
TIGRFAMs	TIGR01307. Pgm_bpd_ind. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GPMI_UREPA

Accession

Primary (citable) accession number: Q9PQW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program