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Q9PQV8

- PFKA_UREPA

UniProt

Q9PQV8 - PFKA_UREPA

Protein

Probable ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.By similarity

    Catalytic activityi

    ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201ATP; via amide nitrogenBy similarity
    Active sitei138 – 1381Proton acceptorBy similarity
    Binding sitei235 – 2351SubstrateBy similarity
    Binding sitei259 – 2591Substrate; shared with dimeric partnerBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 832ATPBy similarity

    GO - Molecular functioni

    1. 6-phosphofructokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fructose 6-phosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciUPAR273119:GHVP-193-MONOMER.
    UniPathwayiUPA00109; UER00182.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent 6-phosphofructokinase (EC:2.7.1.11)
    Short name:
    ATP-PFK
    Short name:
    Phosphofructokinase
    Alternative name(s):
    Phosphohexokinase
    Gene namesi
    Name:pfkA
    Ordered Locus Names:UU185
    OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
    Taxonomic identifieri273119 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
    ProteomesiUP000000423: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. 6-phosphofructokinase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Probable ATP-dependent 6-phosphofructokinasePRO_0000112004Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi273119.UU185.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PQV8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni136 – 1383Substrate bindingBy similarity
    Regioni180 – 1823Substrate bindingBy similarity
    Regioni265 – 2684Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0205.
    HOGENOMiHOG000048829.
    KOiK00850.
    OMAiISHRIAT.
    OrthoDBiEOG644ZRM.

    Family and domain databases

    InterProiIPR012003. ATP_PFK_prok.
    IPR022953. Phosphofructokinase.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view]
    PfamiPF00365. PFK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSiPR00476. PHFRCTKINASE.
    SUPFAMiSSF53784. SSF53784. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9PQV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQVNFLNLD KNILIITSGG DAPGMNASLI SLIHRLMNNN FNVFIGIEGL    50
    LGLYNNLIEP IKDKRVFDVY FNEQGTVIKT SRFIKLDIND KKTQIIKDNL 100
    LSHNIQKIII LGGQGSMQAG LVLTKMGFEV FGILHTIDND FSETQMCIGA 150
    LSAASFNQKL LKCLNYTAKA HCAFNLVELM GRECSWLVNN SVGKLKPILM 200
    LTNQDNKYTV DEVIDLIKDK INSIKEYDPL IIVQELIYDQ KWYELLVKTF 250
    EQKLHKSLRI TILNYLQRGA PVSDFDLQLA KDSANVLVDF IVNQNDIKNT 300
    NNMYVVINKF DNKLEVIKFN K 321
    Length:321
    Mass (Da):36,542
    Last modified:October 1, 2000 - v1
    Checksum:i3087C6061E9F546C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222894 Genomic DNA. Translation: AAF30592.1.
    RefSeqiNP_078017.1. NC_002162.1.

    Genome annotation databases

    EnsemblBacteriaiAAF30592; AAF30592; UU185.
    GeneIDi875859.
    KEGGiuur:UU185.
    PATRICi20533912. VBIUrePar45146_0192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222894 Genomic DNA. Translation: AAF30592.1 .
    RefSeqi NP_078017.1. NC_002162.1.

    3D structure databases

    ProteinModelPortali Q9PQV8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273119.UU185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF30592 ; AAF30592 ; UU185 .
    GeneIDi 875859.
    KEGGi uur:UU185.
    PATRICi 20533912. VBIUrePar45146_0192.

    Phylogenomic databases

    eggNOGi COG0205.
    HOGENOMi HOG000048829.
    KOi K00850.
    OMAi ISHRIAT.
    OrthoDBi EOG644ZRM.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00182 .
    BioCyci UPAR273119:GHVP-193-MONOMER.

    Family and domain databases

    InterProi IPR012003. ATP_PFK_prok.
    IPR022953. Phosphofructokinase.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view ]
    Pfami PF00365. PFK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSi PR00476. PHFRCTKINASE.
    SUPFAMi SSF53784. SSF53784. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
      Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
      Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700970.

    Entry informationi

    Entry nameiPFKA_UREPA
    AccessioniPrimary (citable) accession number: Q9PQV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3