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Protein

Probable ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.By similarity

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.By similarity
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20ATP; via amide nitrogenBy similarity1
Active sitei138Proton acceptorBy similarity1
Binding sitei235SubstrateBy similarity1
Binding sitei259Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 83ATPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent 6-phosphofructokinase (EC:2.7.1.11)
Short name:
ATP-PFK
Short name:
Phosphofructokinase
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkA
Ordered Locus Names:UU185
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000000423 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001120041 – 321Probable ATP-dependent 6-phosphofructokinaseAdd BLAST321

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi273119.UU185

Structurei

3D structure databases

ProteinModelPortaliQ9PQV8
SMRiQ9PQV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 138Substrate bindingBy similarity3
Regioni180 – 182Substrate bindingBy similarity3
Regioni265 – 268Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107S9E Bacteria
COG0205 LUCA
HOGENOMiHOG000048829
KOiK00850
OMAiDESGGAM

Family and domain databases

InterProiView protein in InterPro
IPR022953 ATP_PFK
IPR012003 ATP_PFK_prok-type
IPR000023 Phosphofructokinase_dom
IPR035966 PKF_sf
PfamiView protein in Pfam
PF00365 PFK, 1 hit
PIRSFiPIRSF000532 ATP_PFK_prok, 1 hit
PRINTSiPR00476 PHFRCTKINASE
SUPFAMiSSF53784 SSF53784, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PQV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQVNFLNLD KNILIITSGG DAPGMNASLI SLIHRLMNNN FNVFIGIEGL
60 70 80 90 100
LGLYNNLIEP IKDKRVFDVY FNEQGTVIKT SRFIKLDIND KKTQIIKDNL
110 120 130 140 150
LSHNIQKIII LGGQGSMQAG LVLTKMGFEV FGILHTIDND FSETQMCIGA
160 170 180 190 200
LSAASFNQKL LKCLNYTAKA HCAFNLVELM GRECSWLVNN SVGKLKPILM
210 220 230 240 250
LTNQDNKYTV DEVIDLIKDK INSIKEYDPL IIVQELIYDQ KWYELLVKTF
260 270 280 290 300
EQKLHKSLRI TILNYLQRGA PVSDFDLQLA KDSANVLVDF IVNQNDIKNT
310 320
NNMYVVINKF DNKLEVIKFN K
Length:321
Mass (Da):36,542
Last modified:October 1, 2000 - v1
Checksum:i3087C6061E9F546C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA Translation: AAF30592.1
RefSeqiWP_006689121.1, NC_002162.1

Genome annotation databases

EnsemblBacteriaiAAF30592; AAF30592; UU185
GeneIDi29672722
KEGGiuur:UU185

Similar proteinsi

Entry informationi

Entry nameiPFKA_UREPA
AccessioniPrimary (citable) accession number: Q9PQV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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