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Q9PQV8 (K6PF_UREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-phosphofructokinase

Short name=Phosphofructokinase
EC=2.7.1.11
Alternative name(s):
Phosphohexokinase
Gene names
Name:pfkA
Ordered Locus Names:UU185
OrganismUreaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]
Taxonomic identifier273119 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339.

Sequence similarities

Belongs to the phosphofructokinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termAllosteric enzyme
Complete proteome
Gene Ontology (GO)
   Biological_processfructose 6-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_component6-phosphofructokinase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_function6-phosphofructokinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3213216-phosphofructokinase HAMAP-Rule MF_00339
PRO_0000112004

Regions

Nucleotide binding30 – 345ATP By similarity
Nucleotide binding165 – 1695ATP By similarity
Nucleotide binding182 – 19716ATP By similarity

Sites

Active site1381Proton acceptor By similarity
Binding site2591Substrate By similarity
Binding site2681Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PQV8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3087C6061E9F546C

FASTA32136,542
        10         20         30         40         50         60 
MNQVNFLNLD KNILIITSGG DAPGMNASLI SLIHRLMNNN FNVFIGIEGL LGLYNNLIEP 

        70         80         90        100        110        120 
IKDKRVFDVY FNEQGTVIKT SRFIKLDIND KKTQIIKDNL LSHNIQKIII LGGQGSMQAG 

       130        140        150        160        170        180 
LVLTKMGFEV FGILHTIDND FSETQMCIGA LSAASFNQKL LKCLNYTAKA HCAFNLVELM 

       190        200        210        220        230        240 
GRECSWLVNN SVGKLKPILM LTNQDNKYTV DEVIDLIKDK INSIKEYDPL IIVQELIYDQ 

       250        260        270        280        290        300 
KWYELLVKTF EQKLHKSLRI TILNYLQRGA PVSDFDLQLA KDSANVLVDF IVNQNDIKNT 

       310        320 
NNMYVVINKF DNKLEVIKFN K 

« Hide

References

[1]"The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700970.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF222894 Genomic DNA. Translation: AAF30592.1.
RefSeqNP_078017.1. NC_002162.1.

3D structure databases

ProteinModelPortalQ9PQV8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273119.UU185.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF30592; AAF30592; UU185.
GeneID875859.
KEGGuur:UU185.
PATRIC20533912. VBIUrePar45146_0192.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0205.
HOGENOMHOG000048829.
KOK00850.
OMAEGRSNAI.
OrthoDBEOG644ZRM.
ProtClustDBCLSK2298820.

Enzyme and pathway databases

BioCycUPAR273119:GHVP-193-MONOMER.
UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. SSF53784. 1 hit.
ProtoNetSearch...

Entry information

Entry nameK6PF_UREPA
AccessionPrimary (citable) accession number: Q9PQV8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways