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Q9PQV8

- PFKA_UREPA

UniProt

Q9PQV8 - PFKA_UREPA

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Protein

Probable ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.By similarity

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

Cofactori

Mg2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201ATP; via amide nitrogenBy similarity
Active sitei138 – 1381Proton acceptorBy similarity
Binding sitei235 – 2351SubstrateBy similarity
Binding sitei259 – 2591Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 832ATPBy similarity

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUPAR273119:GHVP-193-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent 6-phosphofructokinase (EC:2.7.1.11)
Short name:
ATP-PFK
Short name:
Phosphofructokinase
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkA
Ordered Locus Names:UU185
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000000423: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Probable ATP-dependent 6-phosphofructokinasePRO_0000112004Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi273119.UU185.

Structurei

3D structure databases

ProteinModelPortaliQ9PQV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni136 – 1383Substrate bindingBy similarity
Regioni180 – 1823Substrate bindingBy similarity
Regioni265 – 2684Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000048829.
KOiK00850.
OMAiISHRIAT.
OrthoDBiEOG644ZRM.

Family and domain databases

InterProiIPR012003. ATP_PFK_prok-type.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PQV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQVNFLNLD KNILIITSGG DAPGMNASLI SLIHRLMNNN FNVFIGIEGL
60 70 80 90 100
LGLYNNLIEP IKDKRVFDVY FNEQGTVIKT SRFIKLDIND KKTQIIKDNL
110 120 130 140 150
LSHNIQKIII LGGQGSMQAG LVLTKMGFEV FGILHTIDND FSETQMCIGA
160 170 180 190 200
LSAASFNQKL LKCLNYTAKA HCAFNLVELM GRECSWLVNN SVGKLKPILM
210 220 230 240 250
LTNQDNKYTV DEVIDLIKDK INSIKEYDPL IIVQELIYDQ KWYELLVKTF
260 270 280 290 300
EQKLHKSLRI TILNYLQRGA PVSDFDLQLA KDSANVLVDF IVNQNDIKNT
310 320
NNMYVVINKF DNKLEVIKFN K
Length:321
Mass (Da):36,542
Last modified:October 1, 2000 - v1
Checksum:i3087C6061E9F546C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF30592.1.
RefSeqiNP_078017.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF30592; AAF30592; UU185.
GeneIDi875859.
KEGGiuur:UU185.
PATRICi20533912. VBIUrePar45146_0192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF30592.1 .
RefSeqi NP_078017.1. NC_002162.1.

3D structure databases

ProteinModelPortali Q9PQV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273119.UU185.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF30592 ; AAF30592 ; UU185 .
GeneIDi 875859.
KEGGi uur:UU185.
PATRICi 20533912. VBIUrePar45146_0192.

Phylogenomic databases

eggNOGi COG0205.
HOGENOMi HOG000048829.
KOi K00850.
OMAi ISHRIAT.
OrthoDBi EOG644ZRM.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci UPAR273119:GHVP-193-MONOMER.

Family and domain databases

InterProi IPR012003. ATP_PFK_prok-type.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
    Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
    Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700970.

Entry informationi

Entry nameiPFKA_UREPA
AccessioniPrimary (citable) accession number: Q9PQV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3