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Protein

Probable ATP-dependent 6-phosphofructokinase

Gene

pfkA

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.By similarity

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.

Cofactori

Mg2+By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201ATP; via amide nitrogenBy similarity
Active sitei138 – 1381Proton acceptorBy similarity
Binding sitei235 – 2351SubstrateBy similarity
Binding sitei259 – 2591Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 832ATPBy similarity

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUPAR273119:GHVP-193-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent 6-phosphofructokinase (EC:2.7.1.11)
Short name:
ATP-PFK
Short name:
Phosphofructokinase
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkA
Ordered Locus Names:UU185
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000000423 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Probable ATP-dependent 6-phosphofructokinasePRO_0000112004Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi273119.UU185.

Structurei

3D structure databases

ProteinModelPortaliQ9PQV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni136 – 1383Substrate bindingBy similarity
Regioni180 – 1823Substrate bindingBy similarity
Regioni265 – 2684Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000048829.
KOiK00850.
OMAiVEILCAG.
OrthoDBiEOG644ZRM.

Family and domain databases

InterProiIPR012003. ATP_PFK_prok-type.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PQV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQVNFLNLD KNILIITSGG DAPGMNASLI SLIHRLMNNN FNVFIGIEGL
60 70 80 90 100
LGLYNNLIEP IKDKRVFDVY FNEQGTVIKT SRFIKLDIND KKTQIIKDNL
110 120 130 140 150
LSHNIQKIII LGGQGSMQAG LVLTKMGFEV FGILHTIDND FSETQMCIGA
160 170 180 190 200
LSAASFNQKL LKCLNYTAKA HCAFNLVELM GRECSWLVNN SVGKLKPILM
210 220 230 240 250
LTNQDNKYTV DEVIDLIKDK INSIKEYDPL IIVQELIYDQ KWYELLVKTF
260 270 280 290 300
EQKLHKSLRI TILNYLQRGA PVSDFDLQLA KDSANVLVDF IVNQNDIKNT
310 320
NNMYVVINKF DNKLEVIKFN K
Length:321
Mass (Da):36,542
Last modified:September 30, 2000 - v1
Checksum:i3087C6061E9F546C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF30592.1.
RefSeqiNP_078017.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF30592; AAF30592; UU185.
KEGGiuur:UU185.
PATRICi20533912. VBIUrePar45146_0192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF30592.1.
RefSeqiNP_078017.1. NC_002162.1.

3D structure databases

ProteinModelPortaliQ9PQV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273119.UU185.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF30592; AAF30592; UU185.
KEGGiuur:UU185.
PATRICi20533912. VBIUrePar45146_0192.

Phylogenomic databases

eggNOGiCOG0205.
HOGENOMiHOG000048829.
KOiK00850.
OMAiVEILCAG.
OrthoDBiEOG644ZRM.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00182.
BioCyciUPAR273119:GHVP-193-MONOMER.

Family and domain databases

InterProiIPR012003. ATP_PFK_prok-type.
IPR022953. Phosphofructokinase.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
    Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
    Nature 407:757-762(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700970.

Entry informationi

Entry nameiPFKA_UREPA
AccessioniPrimary (citable) accession number: Q9PQV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2001
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.