Q9PQV6 (RPOB_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta
Short name=RNAP subunit beta
EC=2.7.7.6

Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta

Gene names

Name:	rpoB
Ordered Locus Names:	UU187

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	1434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01321
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01321
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.
Sequence similarities	Belongs to the RNA polymerase beta chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1434	1434	DNA-directed RNA polymerase subunit beta HAMAP MF_01321		PRO_0000047991

Sequences

	Sequence		Length	Mass (Da)
	Q9PQV6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2841BFA50C19BA7A	FASTA	1,434	162,023
	10 20 30 40 50 60 MQNNKNYTEK FITDKVMRRD YSKIKSNFEG PNLLEIQVES FKRFMEKDLK EVISSIFPLK 70 80 90 100 110 120 SPQGKYTLAF KGLKIKQPTK DESACRDEGK TFETPIYIDL ELTDNYTGEV KRAQRNTKTG 130 140 150 160 170 180 EDGIYLGAIP KMTEKGTFVI NGIEKFVISQ IVRSPGIYVL GKSSIKLNGS RKRLFEGKIC 190 200 210 220 230 240 EIYPSKGTLM LGYIPKDRHN IQIVARDSSG DNAQTFSVTT LLKAFGLTSA EILKIFNNEK 250 260 270 280 290 300 EIRESLEIEK YAPEYIFENS QENEIIFKIY SDAHDIHEKA DRRESNNKLK EEYIEQGSPL 310 320 330 340 350 360 LSKLKQLIFN YVEKNDEIDA LLHENKDVED ASFIKNNKKL YDEREEIINC IISEKAAKDI 370 380 390 400 410 420 VELLGINIKN IETLRHLGKA SYQIALQQHF FNKRLYDISS AGRYKFEKKL LLSERLYQKV 430 440 450 460 470 480 IANDIIDKKN NILIPKDTLI TKEHIELIKK ESRDKNIKWT KKINLLPTAL ESEIEQFLEY 490 500 510 520 530 540 ESIAVYKDND LRDETTEIVG LASGCKLQTL TVADLVATTS YIYNLNYEIG EFDDIDHLGN 550 560 570 580 590 600 KRLKLIHELL RARIATSMAR IEKFINEKLA ISDGSSNNIT NVNDKGIDTE LDREIEESDM 610 620 630 640 650 660 SDEEKKKAIS VKSIINTKQF QSLVKDFFNS HQLIQFIDQQ NPLAELTNKR RISAMGPGGI 670 680 690 700 710 720 SREDPNLDIR DVHHSHSSRI CPIETPEGMN IGLIMSLASL AKVDENGFIV APYYVVEDGV 730 740 750 760 770 780 VKEDYKYLTA HEDDNYIIAE SSVQLDENKR ILDEQVVARY RGSTGLFSPN EVDFIDIVPK 790 800 810 820 830 840 QVVSIAASAI PFIENDDGAR ALMGSNMQRQ ATPLIKPYAP IVGTGTEFKI AHDSGMAVVA 850 860 870 880 890 900 KNDGVVEFVD SQKIIIRNDN DKLDDYKLIK YRKSNQDTCN NQIPIVKVGQ RVHKSETIGD 910 920 930 940 950 960 GPAMQNGELA LGRNILVGYT TWRGYNFEDA IIISERLVDQ DVFTSIHIDE HTIQCMKTKN 970 980 990 1000 1010 1020 GDEEITRDMP NVSDTAKRFL DNQGIVLVGA EVHEGDVLVG KTTPRGNVET APEDRLLQTI 1030 1040 1050 1060 1070 1080 FGDKSKTVKD SSLKVKHGQE GIVAAVKRIK SSDENGSELP DDVIEIIKVY IVQKRKIQVG 1090 1100 1110 1120 1130 1140 DKMAGRHGNK GIVSKVVPIQ DMPFLKDGTP LDIMLNPLGV PSRMNIGQIL ELHLGYAAAE 1150 1160 1170 1180 1190 1200 IGKKQLIQIA IDQLGYEKYI SLFGINEIIA KKLYENISNL IKHKQAKQAK DIDLIDVTII 1210 1220 1230 1240 1250 1260 LKELGLSYDD IGIKISTPVF DGANHDDIVS IMNEANIDIE NNKGKQVLYD GRTGEPFDGL 1270 1280 1290 1300 1310 1320 ISVGLTYMLK LDHMVDDKIH SRSVGPYSKI TQQPLGGKSQ NGGQRFGEME VWALEAYGAA 1330 1340 1350 1360 1370 1380 YNLLEILTIK SDDVQGRNQA YNAIIKGHDV VADGMPESFK LLTKQMQGLG LCITVETKDD 1390 1400 1410 1420 1430 RMVDINEYTL NQNRLNNDDD EVILDENLKE INDSNEEIFN TNFNNNDYDD EENF

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30594.1.
RefSeq	NP_078019.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQV6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875829.
GenomeReviews	Gene locus UU187 in contig AF222894_GR.
KEGG	uur:UU187.
PATRIC	20533916. VBIUrePar45146_0194.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285547.
OMA	VDARDTK.
ProtClustDB	PRK00405.
Enzyme and pathway databases
BioCyc	UURE95667:UU187-MONOMER.
Family and domain databases
HAMAP	MF_01321. RNApol_bact_RpoB. [Tree]
InterPro	IPR010243. DNA-dir_RNA_pol_bsu_bac-type. IPR019462. DNA-dir_RNA_pol_bsu_external_1. IPR015712. DNA-dir_RNA_pol_su2. IPR007120. DNA-dir_RNA_pol_su2_6. IPR007121. RNA_pol_bsu_CS. IPR007644. RNA_pol_bsu_protrusion. IPR007642. RNA_pol_Rpb2_2. IPR007645. RNA_pol_Rpb2_3. IPR007641. RNA_pol_Rpb2_7. IPR014724. RNA_pol_RPB2_OB-fold. [Graphical view]
Gene3D	G3DSA:2.30.150.10. G3DSA:2.30.150.10. 1 hit. G3DSA:2.40.270.10. G3DSA:2.40.270.10. 3 hits. G3DSA:2.40.50.150. Ribosomal_L2. 1 hit.
KO	K03043.
PANTHER	PTHR20856:SF3. PTHR20856:SF3. 1 hit. PTHR20856. RNA_pol_I_sub2. 1 hit.
Pfam	PF04563. RNA_pol_Rpb2_1. 1 hit. PF04561. RNA_pol_Rpb2_2. 1 hit. PF04565. RNA_pol_Rpb2_3. 1 hit. PF10385. RNA_pol_Rpb2_45. 1 hit. PF00562. RNA_pol_Rpb2_6. 1 hit. PF04560. RNA_pol_Rpb2_7. 1 hit. [Graphical view]
PROSITE	PS01166. RNA_POL_BETA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPOB_UREPA

Accession

Primary (citable) accession number: Q9PQV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program