Q9PQV5 (RPOC_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA-directed RNA polymerase subunit beta'
Short name=RNAP subunit beta'
EC=2.7.7.6

Alternative name(s):
RNA polymerase subunit beta'
Transcriptase subunit beta'

Gene names

Name:	rpoC
Ordered Locus Names:	UU188

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	1305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. HAMAP MF_01322
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP MF_01322
Subunit structure	The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.
Sequence similarities	Belongs to the RNA polymerase beta' chain family.

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1305	1305	DNA-directed RNA polymerase subunit beta' HAMAP MF_01322		PRO_0000067826

Sequences

	Sequence		Length	Mass (Da)
	Q9PQV5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: BB3C3938B7CC866F	FASTA	1,305	147,970
	10 20 30 40 50 60 MSQKGIKSLT ISIASPEQIL NWSKGEITKP ETINYKSLKP EPNGLFDESI FGPSKDYECY 70 80 90 100 110 120 CGKYRKVKHK GKICERCHVE ITESIVRRER MGHIELAAPV AHIWFTKELP SPSKISLLLD 130 140 150 160 170 180 ITYKEVDQVV YFVNYIVLDE GNNVYDGKSI FNKKEVLDLT SPKNSIRSRN KLRRTLRNIQ 190 200 210 220 230 240 ERIEDELNHE REALIQDFDY RLAVTYDQML KDSNIPFSVK DVMAFIEKHT GVRFGIGAEA 250 260 270 280 290 300 IRELLEKLNL EEEHEKIKQA IQNSPNAYDQ KTKRLLRRLE CVRWIKDSGS KPEWMVMTRI 310 320 330 340 350 360 PVTPSETRPI ISLDGGRFTT SDTNNFYRKI IIRNERLKQM QATDAPEILL DNEKRLLQEA 370 380 390 400 410 420 VDSLFDNNSR KKPVVGKDKR PLKSLSNHLK GKQGLFRQNL LGKRVDYSGR SVIVVGPELK 430 440 450 460 470 480 MYEVGIPALM ILKLFRPYII SELIRKRDEL GNEIQPICAN IKLAEQKILA QDNEIWPVVE 490 500 510 520 530 540 KVIKQRPVIL NRAPTLHRLG IQAFEPKMVD GKAIRLHPLV TTAFNADFDG DQMAVHIPLS 550 560 570 580 590 600 KEAVAEARSI LLASWHILGP KDGKPIITPT QDMILGIYYL TKEKFPQVIE EMMAKDPTQA 610 620 630 640 650 660 RVEFINNFHI FSTQDEAIRA YKLKTIRIND VIGITTKAFN NKTFSKEGIL VTTVGKIIFN 670 680 690 700 710 720 QAFPVNFPYI NDVKNLYGEN QFEIIGMHES ILDYLKAYNL KEPLTKKTLS TVIDYLYKVS 730 740 750 760 770 780 EIEVVPQTMD KIKALGFKYS MISATSISAF DIPSYDQKYE YFKETDELVS KLREFYLDGK 790 800 810 820 830 840 LTDDERYTKV VQAWSQTKDK VTHDIEKLIN SNEYKDNPIV IMAKSGARGN TSNFTQLAGM 850 860 870 880 890 900 RGLMSKSYNY DQKNNNGVIK DTIEIPIKHS FIEGLSVSEY FNSSFGARKG MTDTAMKTAK 910 920 930 940 950 960 SGYMTRKLVD STQAVVIKDH DCGTKEGIIV REIRNTKDNT SIESLKDRIV GRYSINTIYD 970 980 990 1000 1010 1020 TKNKLIIESD KLITSEIANI IQNSGIREVE VRSPLHCASL YGVCQKCFGL DLSTNKLIET 1030 1040 1050 1060 1070 1080 GTAIGVIAAQ SIGEPGTQLT MRTFHTGGVA GDTNITQGFE RIKQLFDCIQ PQENEKAVIS 1090 1100 1110 1120 1130 1140 QVKGTVERIE KDSNTNGYNV VIKYNKDNYV NYPTRSNAVL RVKTGDEIIA GQKITEGSID 1150 1160 1170 1180 1190 1200 VNDLLKYAGI ENVRHYIIKE VQKVYRMQGI EISDKYIEVI ISQLTNKITI TNPGDSGLFV 1210 1220 1230 1240 1250 1260 GETISINEFT EVAQNMLVNK KKPPSAINQV FGLDHAPSKS GSFLSAASFQ DTKKILTDAA 1270 1280 1290 1300 ARSQKDMLIG LKENVILGNL IPAGTGLKDV EEVIAYGEEM YKKQY

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30595.1.
RefSeq	NP_078020.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQV5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	875923.
GenomeReviews	Gene locus UU188 in contig AF222894_GR.
KEGG	uur:UU188.
PATRIC	20533918. VBIUrePar45146_0195.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG621785.
OMA	DINDKHI.
ProtClustDB	PRK00566.
Enzyme and pathway databases
BioCyc	UURE95667:UU188-MONOMER.
Family and domain databases
HAMAP	MF_01322. RNApol_bact_RpoC. [Tree]
InterPro	IPR012754. DNA-dir_RpoC_beta_prime. IPR000722. RNA_pol_asu. IPR006592. RNA_pol_N. IPR007080. RNA_pol_Rpb1_1. IPR007066. RNA_pol_Rpb1_3. IPR007083. RNA_pol_Rpb1_4. IPR007081. RNA_pol_Rpb1_5. [Graphical view]
KO	K03046.
Pfam	PF04997. RNA_pol_Rpb1_1. 1 hit. PF00623. RNA_pol_Rpb1_2. 1 hit. PF04983. RNA_pol_Rpb1_3. 1 hit. PF05000. RNA_pol_Rpb1_4. 1 hit. PF04998. RNA_pol_Rpb1_5. 1 hit. [Graphical view]
SMART	SM00663. RPOLA_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02386. RpoC_TIGR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPOC_UREPA

Accession

Primary (citable) accession number: Q9PQV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program