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Q9PQS1 (FTHS_UREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Synonyms:fthS
Ordered Locus Names:UU221
OrganismUreaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]
Taxonomic identifier273119 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199406

Sequences

Sequence LengthMass (Da)Tools
Q9PQS1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F2C5D80295186092

FASTA52158,466
        10         20         30         40         50         60 
MAKIIEEMIN KKGLLIDDYE LYGNEIAKIK SIKKLNKKDS KLIVITSMNP NPAGEGKTTT 

        70         80         90        100        110        120 
AIGLVDALNK HGYKAIGALR EPSMGPVFGM KGTGSGGGLS FLKPFDKINL HFSGDFHAIT 

       130        140        150        160        170        180 
AANNLIVAVI ENEIHNRSSM QIDSQKILIK RCLDVNDRSL RNIEYDINHQ QTKSGFNITA 

       190        200        210        220        230        240 
ASDLMALFCL AHDHKDFEDK LAQTIVAYNI VNQPIRICDL ELTKAIMAIL EDALYANLVR 

       250        260        270        280        290        300 
TNEDNPVFVH GGPFANIAHG CNSIIATKNA LALGDYVVTE CGFGSDLGLE KFMNIKMASL 

       310        320        330        340        350        360 
NLKPDLIGLV ISLKSIAYHA QTNEKDYVKQ GFANVLCHIN HIKKYNVSFI VYINVNTNTD 

       370        380        390        400        410        420 
SEEDLLTLEK LLDEHQIEHA RSYAYSYGSK KSEEITKKTI TLTNQINDHE LKLIYDIKDH 

       430        440        450        460        470        480 
LSYKLKKICE NVYGADGYEL SYEAKEQLNR YEHLDFYLCI AKTPYSISDD AKLLNNPKNF 

       490        500        510        520 
KIHIERFEIN YAAKLIIAIT TTIYRMPGLN KEPAAKNFVM K 

« Hide

References

[1]"The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700970.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF222894 Genomic DNA. Translation: AAF30629.1.
RefSeqNP_078054.1. NC_002162.1.

3D structure databases

ProteinModelPortalQ9PQS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273119.UU221.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF30629; AAF30629; UU221.
GeneID876396.
KEGGuur:UU221.
PATRIC20533986. VBIUrePar45146_0229.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK2298835.

Enzyme and pathway databases

BioCycUPAR273119:GHVP-229-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_UREPA
AccessionPrimary (citable) accession number: Q9PQS1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways