Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9PQS1

- FTHS_UREPA

UniProt

Q9PQS1 - FTHS_UREPA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUPAR273119:GHVP-229-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Synonyms:fthS
Ordered Locus Names:UU221
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000000423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Formate--tetrahydrofolate ligasePRO_0000199406Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273119.UU221.

Structurei

3D structure databases

ProteinModelPortaliQ9PQS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PQS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKIIEEMIN KKGLLIDDYE LYGNEIAKIK SIKKLNKKDS KLIVITSMNP
60 70 80 90 100
NPAGEGKTTT AIGLVDALNK HGYKAIGALR EPSMGPVFGM KGTGSGGGLS
110 120 130 140 150
FLKPFDKINL HFSGDFHAIT AANNLIVAVI ENEIHNRSSM QIDSQKILIK
160 170 180 190 200
RCLDVNDRSL RNIEYDINHQ QTKSGFNITA ASDLMALFCL AHDHKDFEDK
210 220 230 240 250
LAQTIVAYNI VNQPIRICDL ELTKAIMAIL EDALYANLVR TNEDNPVFVH
260 270 280 290 300
GGPFANIAHG CNSIIATKNA LALGDYVVTE CGFGSDLGLE KFMNIKMASL
310 320 330 340 350
NLKPDLIGLV ISLKSIAYHA QTNEKDYVKQ GFANVLCHIN HIKKYNVSFI
360 370 380 390 400
VYINVNTNTD SEEDLLTLEK LLDEHQIEHA RSYAYSYGSK KSEEITKKTI
410 420 430 440 450
TLTNQINDHE LKLIYDIKDH LSYKLKKICE NVYGADGYEL SYEAKEQLNR
460 470 480 490 500
YEHLDFYLCI AKTPYSISDD AKLLNNPKNF KIHIERFEIN YAAKLIIAIT
510 520
TTIYRMPGLN KEPAAKNFVM K
Length:521
Mass (Da):58,466
Last modified:October 1, 2000 - v1
Checksum:iF2C5D80295186092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222894 Genomic DNA. Translation: AAF30629.1.
RefSeqiNP_078054.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF30629; AAF30629; UU221.
GeneIDi876396.
KEGGiuur:UU221.
PATRICi20533986. VBIUrePar45146_0229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222894 Genomic DNA. Translation: AAF30629.1 .
RefSeqi NP_078054.1. NC_002162.1.

3D structure databases

ProteinModelPortali Q9PQS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273119.UU221.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF30629 ; AAF30629 ; UU221 .
GeneIDi 876396.
KEGGi uur:UU221.
PATRICi 20533986. VBIUrePar45146_0229.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci UPAR273119:GHVP-229-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
    Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
    Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700970.

Entry informationi

Entry nameiFTHS_UREPA
AccessioniPrimary (citable) accession number: Q9PQS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3