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Q9PQS1

- FTHS_UREPA

UniProt

Q9PQS1 - FTHS_UREPA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciUPAR273119:GHVP-229-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Synonyms:fthS
    Ordered Locus Names:UU221
    OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
    Taxonomic identifieri273119 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
    ProteomesiUP000000423: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Formate--tetrahydrofolate ligasePRO_0000199406Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273119.UU221.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PQS1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIPRESGF.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PQS1-1 [UniParc]FASTAAdd to Basket

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    MAKIIEEMIN KKGLLIDDYE LYGNEIAKIK SIKKLNKKDS KLIVITSMNP    50
    NPAGEGKTTT AIGLVDALNK HGYKAIGALR EPSMGPVFGM KGTGSGGGLS 100
    FLKPFDKINL HFSGDFHAIT AANNLIVAVI ENEIHNRSSM QIDSQKILIK 150
    RCLDVNDRSL RNIEYDINHQ QTKSGFNITA ASDLMALFCL AHDHKDFEDK 200
    LAQTIVAYNI VNQPIRICDL ELTKAIMAIL EDALYANLVR TNEDNPVFVH 250
    GGPFANIAHG CNSIIATKNA LALGDYVVTE CGFGSDLGLE KFMNIKMASL 300
    NLKPDLIGLV ISLKSIAYHA QTNEKDYVKQ GFANVLCHIN HIKKYNVSFI 350
    VYINVNTNTD SEEDLLTLEK LLDEHQIEHA RSYAYSYGSK KSEEITKKTI 400
    TLTNQINDHE LKLIYDIKDH LSYKLKKICE NVYGADGYEL SYEAKEQLNR 450
    YEHLDFYLCI AKTPYSISDD AKLLNNPKNF KIHIERFEIN YAAKLIIAIT 500
    TTIYRMPGLN KEPAAKNFVM K 521
    Length:521
    Mass (Da):58,466
    Last modified:October 1, 2000 - v1
    Checksum:iF2C5D80295186092
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222894 Genomic DNA. Translation: AAF30629.1.
    RefSeqiNP_078054.1. NC_002162.1.

    Genome annotation databases

    EnsemblBacteriaiAAF30629; AAF30629; UU221.
    GeneIDi876396.
    KEGGiuur:UU221.
    PATRICi20533986. VBIUrePar45146_0229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222894 Genomic DNA. Translation: AAF30629.1 .
    RefSeqi NP_078054.1. NC_002162.1.

    3D structure databases

    ProteinModelPortali Q9PQS1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273119.UU221.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF30629 ; AAF30629 ; UU221 .
    GeneIDi 876396.
    KEGGi uur:UU221.
    PATRICi 20533986. VBIUrePar45146_0229.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IPRESGF.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci UPAR273119:GHVP-229-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
      Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
      Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700970.

    Entry informationi

    Entry nameiFTHS_UREPA
    AccessioniPrimary (citable) accession number: Q9PQS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3