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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciUPAR273119:GHVP-229-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Synonyms:fthS
Ordered Locus Names:UU221
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000000423 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Formate--tetrahydrofolate ligasePRO_0000199406Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273119.UU221.

Structurei

3D structure databases

ProteinModelPortaliQ9PQS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PQS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIIEEMIN KKGLLIDDYE LYGNEIAKIK SIKKLNKKDS KLIVITSMNP
60 70 80 90 100
NPAGEGKTTT AIGLVDALNK HGYKAIGALR EPSMGPVFGM KGTGSGGGLS
110 120 130 140 150
FLKPFDKINL HFSGDFHAIT AANNLIVAVI ENEIHNRSSM QIDSQKILIK
160 170 180 190 200
RCLDVNDRSL RNIEYDINHQ QTKSGFNITA ASDLMALFCL AHDHKDFEDK
210 220 230 240 250
LAQTIVAYNI VNQPIRICDL ELTKAIMAIL EDALYANLVR TNEDNPVFVH
260 270 280 290 300
GGPFANIAHG CNSIIATKNA LALGDYVVTE CGFGSDLGLE KFMNIKMASL
310 320 330 340 350
NLKPDLIGLV ISLKSIAYHA QTNEKDYVKQ GFANVLCHIN HIKKYNVSFI
360 370 380 390 400
VYINVNTNTD SEEDLLTLEK LLDEHQIEHA RSYAYSYGSK KSEEITKKTI
410 420 430 440 450
TLTNQINDHE LKLIYDIKDH LSYKLKKICE NVYGADGYEL SYEAKEQLNR
460 470 480 490 500
YEHLDFYLCI AKTPYSISDD AKLLNNPKNF KIHIERFEIN YAAKLIIAIT
510 520
TTIYRMPGLN KEPAAKNFVM K
Length:521
Mass (Da):58,466
Last modified:October 1, 2000 - v1
Checksum:iF2C5D80295186092
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF30629.1.
RefSeqiNP_078054.1. NC_002162.1.
WP_006688872.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF30629; AAF30629; UU221.
GeneIDi876396.
KEGGiuur:UU221.
PATRICi20533986. VBIUrePar45146_0229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF30629.1.
RefSeqiNP_078054.1. NC_002162.1.
WP_006688872.1. NC_002162.1.

3D structure databases

ProteinModelPortaliQ9PQS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273119.UU221.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF30629; AAF30629; UU221.
GeneIDi876396.
KEGGiuur:UU221.
PATRICi20533986. VBIUrePar45146_0229.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciUPAR273119:GHVP-229-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
    Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
    Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700970.

Entry informationi

Entry nameiFTHS_UREPA
AccessioniPrimary (citable) accession number: Q9PQS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2000
Last modified: May 27, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.