Q9PQS1 (FTHS_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Synonyms:	fthS
Ordered Locus Names:	UU221

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Ureaplasma › Ureaplasma parvum › Ureaplasma parvum serovar 3

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro tetrahydrofolate interconversion Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543		PRO_0000199406

Sequences

	Sequence		Length	Mass (Da)
	Q9PQS1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F2C5D80295186092	FASTA	521	58,466
	10 20 30 40 50 60 MAKIIEEMIN KKGLLIDDYE LYGNEIAKIK SIKKLNKKDS KLIVITSMNP NPAGEGKTTT 70 80 90 100 110 120 AIGLVDALNK HGYKAIGALR EPSMGPVFGM KGTGSGGGLS FLKPFDKINL HFSGDFHAIT 130 140 150 160 170 180 AANNLIVAVI ENEIHNRSSM QIDSQKILIK RCLDVNDRSL RNIEYDINHQ QTKSGFNITA 190 200 210 220 230 240 ASDLMALFCL AHDHKDFEDK LAQTIVAYNI VNQPIRICDL ELTKAIMAIL EDALYANLVR 250 260 270 280 290 300 TNEDNPVFVH GGPFANIAHG CNSIIATKNA LALGDYVVTE CGFGSDLGLE KFMNIKMASL 310 320 330 340 350 360 NLKPDLIGLV ISLKSIAYHA QTNEKDYVKQ GFANVLCHIN HIKKYNVSFI VYINVNTNTD 370 380 390 400 410 420 SEEDLLTLEK LLDEHQIEHA RSYAYSYGSK KSEEITKKTI TLTNQINDHE LKLIYDIKDH 430 440 450 460 470 480 LSYKLKKICE NVYGADGYEL SYEAKEQLNR YEHLDFYLCI AKTPYSISDD AKLLNNPKNF 490 500 510 520 KIHIERFEIN YAAKLIIAIT TTIYRMPGLN KEPAAKNFVM K

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30629.1.
RefSeq	NP_078054.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQS1.
ModBase	Search...
Protein-protein interaction databases
STRING	273119.UU221.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF30629; AAF30629; UU221.
GeneID	876396.
KEGG	uur:UU221.
PATRIC	20533986. VBIUrePar45146_0229.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HOG000040280.
KO	K01938.
OMA	EIMAVLC.
ProtClustDB	CLSK2298835.
Enzyme and pathway databases
UniPathway	UPA00193.
Family and domain databases
HAMAP	MF_01543. FTHFS.
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_UREPA

Accession

Primary (citable) accession number: Q9PQS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program