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Q9PQM2

- TRMB_UREPA

UniProt

Q9PQM2 - TRMB_UREPA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei45 – 451S-adenosyl-L-methionineUniRule annotation
    Binding sitei70 – 701S-adenosyl-L-methionineUniRule annotation
    Binding sitei97 – 971S-adenosyl-L-methionineUniRule annotation
    Active sitei119 – 1191By similarity
    Binding sitei119 – 1191S-adenosyl-L-methionineUniRule annotation
    Binding sitei123 – 1231SubstrateUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciUPAR273119:GHVP-277-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:UU269
    OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
    Taxonomic identifieri273119 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
    ProteomesiUP000000423: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_0000171417Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273119.UU269.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PQM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni199 – 2024Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000251689.
    KOiK03439.
    OMAiGCGKGEY.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PQM2-1 [UniParc]FASTAAdd to Basket

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    MRLRNNANAP LYLKSQHEYI INDPHLLKDN LGKIFKNPEL PLYIEIGMGK    50
    GDFIIENALR NQQINYLGIE KFPTVIVKAH KKALKHKLDN LAMICFDANK 100
    ILELLNSESV DKIYLNFSDP WPKKRHAKKR LTHPCFLEKF AVILKQNALV 150
    EFKTDNENLF MYTIYDVLLK DLTKYEILFL TYNLYTLVNN VELLKNIPTE 200
    YEKKFVMQGE RIKKVNFRFL KNNQ 224
    Length:224
    Mass (Da):26,494
    Last modified:October 1, 2000 - v1
    Checksum:iFB6152538C75CBBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222894 Genomic DNA. Translation: AAF30678.1.
    RefSeqiNP_078103.1. NC_002162.1.

    Genome annotation databases

    EnsemblBacteriaiAAF30678; AAF30678; UU269.
    GeneIDi876169.
    KEGGiuur:UU269.
    PATRICi20534084. VBIUrePar45146_0278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF222894 Genomic DNA. Translation: AAF30678.1 .
    RefSeqi NP_078103.1. NC_002162.1.

    3D structure databases

    ProteinModelPortali Q9PQM2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273119.UU269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF30678 ; AAF30678 ; UU269 .
    GeneIDi 876169.
    KEGGi uur:UU269.
    PATRICi 20534084. VBIUrePar45146_0278.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000251689.
    KOi K03439.
    OMAi GCGKGEY.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci UPAR273119:GHVP-277-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
      Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
      Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700970.

    Entry informationi

    Entry nameiTRMB_UREPA
    AccessioniPrimary (citable) accession number: Q9PQM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3