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Q9PQM2

- TRMB_UREPA

UniProt

Q9PQM2 - TRMB_UREPA

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, UU269
Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451S-adenosyl-L-methionine By similarity
Binding sitei70 – 701S-adenosyl-L-methionine By similarity
Binding sitei97 – 971S-adenosyl-L-methionine By similarity
Active sitei119 – 1191 By similarity
Binding sitei119 – 1191S-adenosyl-L-methionine By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei155 – 1551Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciUPAR273119:GHVP-277-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:UU269
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
ProteomesiUP000000423: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171417Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273119.UU269.

Structurei

3D structure databases

ProteinModelPortaliQ9PQM2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2024Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiGCGKGEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PQM2-1 [UniParc]FASTAAdd to Basket

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MRLRNNANAP LYLKSQHEYI INDPHLLKDN LGKIFKNPEL PLYIEIGMGK    50
GDFIIENALR NQQINYLGIE KFPTVIVKAH KKALKHKLDN LAMICFDANK 100
ILELLNSESV DKIYLNFSDP WPKKRHAKKR LTHPCFLEKF AVILKQNALV 150
EFKTDNENLF MYTIYDVLLK DLTKYEILFL TYNLYTLVNN VELLKNIPTE 200
YEKKFVMQGE RIKKVNFRFL KNNQ 224
Length:224
Mass (Da):26,494
Last modified:October 1, 2000 - v1
Checksum:iFB6152538C75CBBF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222894 Genomic DNA. Translation: AAF30678.1.
RefSeqiNP_078103.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF30678; AAF30678; UU269.
GeneIDi876169.
KEGGiuur:UU269.
PATRICi20534084. VBIUrePar45146_0278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF222894 Genomic DNA. Translation: AAF30678.1 .
RefSeqi NP_078103.1. NC_002162.1.

3D structure databases

ProteinModelPortali Q9PQM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273119.UU269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF30678 ; AAF30678 ; UU269 .
GeneIDi 876169.
KEGGi uur:UU269.
PATRICi 20534084. VBIUrePar45146_0278.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi GCGKGEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci UPAR273119:GHVP-277-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
    Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
    Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700970.

Entry informationi

Entry nameiTRMB_UREPA
AccessioniPrimary (citable) accession number: Q9PQM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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