Q9PQH1 (IF2_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor IF-2

Gene names

Name:	infB
Ordered Locus Names:	UU320

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Tenericutes › Mollicutes › Mycoplasmatales › Mycoplasmataceae › Ureaplasma › Ureaplasma parvum › Ureaplasma parvum serovar 3

Protein attributes

Sequence length	614 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IF-2 family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 614	614	Translation initiation factor IF-2 HAMAP-Rule MF_00100		PRO_0000137278
Regions
	Nucleotide binding	124 – 131	8	GTP By similarity
	Nucleotide binding	170 – 174	5	GTP By similarity
	Nucleotide binding	224 – 227	4	GTP By similarity
	Region	118 – 266	149	G-domain HAMAP-Rule MF_00100

Sequences

	Sequence		Length	Mass (Da)
	Q9PQH1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A41FF74375609876	FASTA	614	68,049
	10 20 30 40 50 60 MAKKNIKQKK DNRIAIDVKK HIKKVDVGVF DGTFVFTSPL SISELAPKLN KSPNEIIMRY 70 80 90 100 110 120 FKKGVVYNLN TILDEEQIGE LCLEYDLDFK IEKNVNTENL LENIYFDDLE IDLVARAPIV 130 140 150 160 170 180 TIMGHVDHGK TTLLDTIRKS SITASEAGGI TQHIGAYQII KDNRAITFID TPGHEAFTEM 190 200 210 220 230 240 RARGANLTDI VILVVAADDG IKMQTEEAID HAKAANVPII VFVNKMDKYE ANPEKVLNQL 250 260 270 280 290 300 SAKEIVAEEL GGDVVFVKGS ALKNEGISEL LDSILLIAEL NNYKANPNRL AYGTTIEANL 310 320 330 340 350 360 DKGHGPLATL LVQNGTLRKG DYLVVGSTYG KIRNMFDEYD NEIEIALPSK PVKVSGFEEV 370 380 390 400 410 420 PTAGDKFLAL ADEKQARAIA NDVKQKKMRL ERAMLQSSDI RTKIANGELK NINLIIKADV 430 440 450 460 470 480 QGSLEALKGI FSSINIEGVT TTLIRSAIGT ISESDVRLAQ TSDAIIIGFN VRASRIIKDL 490 500 510 520 530 540 ADSVGVQIMN YDIIYKFKED LELWMKGTLD PIIIEEVIGE AKVLKLFKHS QVGTICGCRV 550 560 570 580 590 600 INGKIKRNAL VRVLRDGIVI YNSKIATLQH NKDSVNEVIA DKECGLTIAN FNDIKENDII 610 EVYIKVEKKH DEVK

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30729.1.
RefSeq	NP_078154.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQH1.
ModBase	Search...
Protein-protein interaction databases
STRING	273119.UU320.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF30729; AAF30729; UU320.
GeneID	875787.
KEGG	uur:UU320.
PATRIC	20534214. VBIUrePar45146_0333.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0532.
HOGENOM	HOG000076906.
KO	K02519.
OMA	ANVAMIV.
ProtClustDB	PRK05306.
Family and domain databases
Gene3D	3.40.50.10050. 1 hit.
HAMAP	MF_00100_B. IF-2_B.
InterPro	IPR000795. EF_GTP-bd_dom. IPR006847. IF2_N. IPR005225. Small_GTP-bd_dom. IPR000178. TF_IF2_bacterial-like. IPR015760. TIF_IF2. IPR023115. TIF_IF2_dom3. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
PANTHER	PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 2 hits. PF11987. IF-2. 1 hit. PF04760. IF2_N. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF52156. TIF_IF2_dom3. 1 hit. SSF50447. Translat_factor. 2 hits.
TIGRFAMs	TIGR00487. IF-2. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS01176. IF2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IF2_UREPA

Accession

Primary (citable) accession number: Q9PQH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program