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Q9PQC6 (SYN_UREPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Asparagine--tRNA ligase
EC=6.1.1.22
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS
Gene names
Name:asnS
Ordered Locus Names:UU365
OrganismUreaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]
Taxonomic identifier273119 [NCBI]
Taxonomic lineageBacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534

Subunit structure

Homodimer By similarity. HAMAP MF_00534

Subcellular location

Cytoplasm HAMAP MF_00534.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processasparaginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

asparagine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Asparagine--tRNA ligase HAMAP MF_00534
PRO_0000176473

Sequences

Sequence LengthMass (Da)Tools
Q9PQC6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8851BF08F7149DEE

FASTA45452,314
        10         20         30         40         50         60 
MQLKIKEIFN QDYVKLEGQK IQIKAWVRSN RDSKKIGFLV LNDGSSLTNL QAVYRVDKID 

        70         80         90        100        110        120 
NYEEIAAARM WAAVVIEGVI KLTPTAKQPL ELEVLNAQIL KQSDEDFLLS NNDLNLETLR 

       130        140        150        160        170        180 
LNAHLRPRTN LFHAIMKVRA TLAFAVHEFM NQNEYSWLAA PLFTGNDAEG AGETFSIQKF 

       190        200        210        220        230        240 
DNEEFFGKQT HLSVTGQLQA EAYAQAFGNV YTFGPTFRAE KSHTNRHLAE FWMIEPEMAF 

       250        260        270        280        290        300 
VDLKGMQDIV EDLVKHVIKA VLEKNQQELE FLAQRNDENL IKKLQKVVES KFERIEYKDA 

       310        320        330        340        350        360 
VKILADAVKN GHQFENNEIF FGMDLGSEHE RYMCETYHQG PVFLQNYPKD IKAFYMKLND 

       370        380        390        400        410        420 
DQQTVASTDL LIPGVGELVG GSQREDSYEK LLKRCQELKM PIESLQWYLD LRRFGYYMSS 

       430        440        450 
GFGIGFERLV MYVTGVNNIK DTIPFPRSHG QIEF

« Hide

References

[1]"The complete sequence of the mucosal pathogen Ureaplasma urealyticum."
Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H.
Nature 407:757-762(2000) [PubMed: 11048724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700970.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF222894 Genomic DNA. Translation: AAF30774.1.
RefSeqNP_078199.1. NC_002162.1.

3D structure databases

ProteinModelPortalQ9PQC6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID876026.
GenomeReviewsGene locus UU365 in contig AF222894_GR.
KEGGuur:UU365.
PATRIC20534306. VBIUrePar45146_0379.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG745843.
OMAAIHRFFH.
ProtClustDBPRK03932.

Enzyme and pathway databases

BioCycUURE95667:UU365-MONOMER.

Family and domain databases

HAMAPMF_00534. Asn_tRNA_synth.
[Tree]
InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-synth_IIb.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR016027. NA-bd_OB-fold-like.
IPR004365. NA-bd_OB_tRNA-helicase.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KOK01893.
PANTHERPTHR22594. aa-tRNA-synt_II. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00457. AsnS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYN_UREPA
AccessionPrimary (citable) accession number: Q9PQC6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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