Q9PQ32 (SYFA_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phenylalanine--tRNA ligase alpha chain
EC=6.1.1.20

Alternative name(s):
Phenylalanyl-tRNA synthetase alpha chain
Short name=PheRS

Gene names

Name:	pheS
Ordered Locus Names:	UU458

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). HAMAP MF_00281
Cofactor	Binds 2 magnesium ions per tetramer By similarity. HAMAP MF_00281
Subunit structure	Tetramer of two alpha and two beta chains By similarity.
Subcellular location	Cytoplasm HAMAP MF_00281.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phenylalanyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phenylalanine-tRNA ligase activity Inferred from electronic annotation. Source: EC tRNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Phenylalanine--tRNA ligase alpha chain HAMAP MF_00281		PRO_0000126790
Sites
	Metal binding	248	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PQ32 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5C4E3530FA34FECF	FASTA	333	38,713
	10 20 30 40 50 60 MDVINLIKNL KQILRTANNE RHLIELKNIF VKQHLLPLYD ELKKSANKKE MGLLINNFKQ 70 80 90 100 110 120 QIEFVTDQIL KELNDKDDQV DLKKWTNKTL FAPFINNGHH HILNSIIDDI ASFFKKLNFE 130 140 150 160 170 180 IVSGSEVVSP IYNFDHLNID ENHPARASAD SFFINSIKML RTHCTTTTAQ FLENNVNKDI 190 200 210 220 230 240 RIMSFGNVYR KDDDDATHSH QFNQVDFVWV KEGLTVANLK WLIDSLIKYL FGQNLKTRYR 250 260 270 280 290 300 LSFFPFTEPS FEVDVQCFKC DLKGCAVCKK STWIEIMGTG MLHENVLKAA NINDIRTGMA 310 320 330 FGVGIDRIAM LKYEIDDIRY LYSNNFKFNA QIK

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30870.1.
RefSeq	NP_078295.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQ32.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876344.
GenomeReviews	Gene locus UU458 in contig AF222894_GR.
KEGG	uur:UU458.
PATRIC	20534499. VBIUrePar45146_0474.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG284353.
OMA	ERITLMI.
ProtClustDB	PRK00488.
Enzyme and pathway databases
BioCyc	UURE95667:UU458-MONOMER.
Family and domain databases
HAMAP	MF_00281. Phe_tRNA_synth_alpha1. [Tree]
InterPro	IPR006195. aa-tRNA-synth_II. IPR004529. Phe-tRNA-synth_IIc_asu. IPR022911. Phe_tRNA_synth_alpha1_bac. IPR002319. Phenylalanyl-tRNA_Synthase. [Graphical view]
KO	K01889.
Pfam	PF01409. tRNA-synt_2d. 1 hit. [Graphical view]
TIGRFAMs	TIGR00468. PheS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYFA_UREPA

Accession

Primary (citable) accession number: Q9PQ32

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program