Q9PQ27 (FMT_UREPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionyl-tRNA formyltransferase
EC=2.1.2.9

Gene names

Name:	fmt
Ordered Locus Names:	UU463

Organism

Ureaplasma parvum serovar 3 (strain ATCC 700970) [Complete proteome] [HAMAP]

Taxonomic identifier

273119 [NCBI]

Taxonomic lineage

Bacteria › Tenericutes › Mollicutes › Mycoplasmataceae › Ureaplasma

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity. HAMAP MF_00182
Catalytic activity	10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H2O = tetrahydrofolate + N-formylmethionyl-tRNA(fMet). HAMAP MF_00182
Sequence similarities	Belongs to the fmt family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	methionyl-tRNA formyltransferase activity Inferred from electronic annotation. Source: EC methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Methionyl-tRNA formyltransferase HAMAP MF_00182		PRO_0000083078
Regions
	Region	110 – 113	4	Tetrahydrofolate (THF) binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PQ27 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 54E5676DE3291240	FASTA	305	34,793
	10 20 30 40 50 60 MKYKVMFFGT PEIAKIVLET LFNMHEVDLI AVVSQPDAHF DRKKNVIYSP VKQFCLDHNI 70 80 90 100 110 120 KLFQPEKIKE IEEEIRILGP DIIITCAFGQ FINQGIIDIP KYKIVNIHAS LLPKLRGGAP 130 140 150 160 170 180 IHYAILNGEL KTGITLMHTI KKMDAGNILF QRSLEINDCT TTKSLTLELA NLSALMIKEH 190 200 210 220 230 240 FLELVKPNLV GIQQDENSVS FAYNIQKDQN IINFDQPAFF INRFVNAMYD KPIAIMQYNG 250 260 270 280 290 300 VSIKVYQVKI TNQKSCQKPG TIMIFKNQLF VSTQDFDIEL LLIQLPNKKP LSPKVLLNGK NPFIN

References

[1]	"The complete sequence of the mucosal pathogen Ureaplasma urealyticum." Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y., Cassell G.H. Nature 407:757-762(2000) [PubMed: 11048724] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700970.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222894 Genomic DNA. Translation: AAF30875.1.
RefSeq	NP_078300.1. NC_002162.1.
3D structure databases
ProteinModelPortal	Q9PQ27.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	876339.
GenomeReviews	Gene locus UU463 in contig AF222894_GR.
KEGG	uur:UU463.
PATRIC	20534509. VBIUrePar45146_0479.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571560.
OMA	VENEKSH.
ProtClustDB	CLSK2298953.
Enzyme and pathway databases
BioCyc	UURE95667:UU463-MONOMER.
Family and domain databases
HAMAP	MF_00182. Formyl_trans. [Tree]
InterPro	IPR005794. Fmt. IPR005793. Formyl_trans_C. IPR002376. Formyl_transf_N. IPR011034. Formyl_transferase_C-like. IPR015518. Met_tRNA_Form_TA-like. [Graphical view]
Gene3D	G3DSA:3.10.25.10. Formyl_trans_C. 1 hit. G3DSA:3.40.50.170. Formyl_transf_N. 1 hit.
KO	K00604.
PANTHER	PTHR11138. Met_tRNA_Form_TA-like. 1 hit.
Pfam	PF02911. Formyl_trans_C. 1 hit. PF00551. Formyl_trans_N. 1 hit. [Graphical view]
SUPFAM	SSF50486. FMT_C_like. 1 hit. SSF53328. formyl_transf. 1 hit.
TIGRFAMs	TIGR00460. Fmt. 1 hit.
PROSITE	PS00373. GART. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FMT_UREPA

Accession

Primary (citable) accession number: Q9PQ27

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program