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Protein

Thymidine kinase

Gene

tdk

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97Proton acceptorUniRule annotation1
Binding sitei128Substrate; via amide nitrogen1
Metal bindingi153Zinc1
Metal bindingi156Zinc1
Binding sitei187Substrate1
Metal bindingi191Zinc1
Metal bindingi194Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26ATPUniRule annotation8
Nucleotide bindingi96 – 99ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.21. 9209.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:UU594
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000000423 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750421 – 223Thymidine kinaseAdd BLAST223

Interactioni

Subunit structurei

Homotetramer.UniRule annotation2 Publications

Protein-protein interaction databases

STRINGi273119.UU594.

Chemistry databases

BindingDBiQ9PPP5.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 18Combined sources6
Helixi25 – 38Combined sources14
Beta strandi43 – 48Combined sources6
Helixi52 – 54Combined sources3
Beta strandi61 – 63Combined sources3
Beta strandi65 – 67Combined sources3
Beta strandi69 – 73Combined sources5
Helixi75 – 82Combined sources8
Beta strandi92 – 95Combined sources4
Helixi98 – 100Combined sources3
Helixi105 – 114Combined sources10
Beta strandi118 – 122Combined sources5
Beta strandi130 – 132Combined sources3
Helixi136 – 142Combined sources7
Beta strandi144 – 148Combined sources5
Turni154 – 156Combined sources3
Beta strandi158 – 160Combined sources3
Beta strandi162 – 167Combined sources6
Turni184 – 186Combined sources3
Beta strandi187 – 190Combined sources4
Helixi192 – 194Combined sources3
Helixi207 – 215Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B8TX-ray2.00A/B/C/D1-223[»]
2UZ3X-ray2.50A/B/C/D1-223[»]
ProteinModelPortaliQ9PPP5.
SMRiQ9PPP5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9PPP5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 182Substrate binding5

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PPP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVNAFSKK IGWIELITGP MFAGKTAELI RRLHRLEYAD VKYLVFKPKI
60 70 80 90 100
DTRSIRNIQS RTGTSLPSVE VESAPEILNY IMSNSFNDET KVIGIDEVQF
110 120 130 140 150
FDDRICEVAN ILAENGFVVI ISGLDKNFKG EPFGPIAKLF TYADKITKLT
160 170 180 190 200
AICNECGAEA THSLRKIDGK HADYNDDIVK IGCQEFYSAV CRHHHKVPNR
210 220
PYLNSNSEEF IKFFKNKKRN KNI
Length:223
Mass (Da):25,367
Last modified:October 1, 2000 - v1
Checksum:i27F3061B26979A0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF31008.1.
RefSeqiWP_006688765.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF31008; AAF31008; UU594.
GeneIDi876009.
KEGGiuur:UU594.
PATRICi20534825. VBIUrePar45146_0617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF31008.1.
RefSeqiWP_006688765.1. NC_002162.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B8TX-ray2.00A/B/C/D1-223[»]
2UZ3X-ray2.50A/B/C/D1-223[»]
ProteinModelPortaliQ9PPP5.
SMRiQ9PPP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273119.UU594.

Chemistry databases

BindingDBiQ9PPP5.
ChEMBLiCHEMBL1075130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF31008; AAF31008; UU594.
GeneIDi876009.
KEGGiuur:UU594.
PATRICi20534825. VBIUrePar45146_0617.

Phylogenomic databases

eggNOGiENOG4107T8J. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Enzyme and pathway databases

BRENDAi2.7.1.21. 9209.

Miscellaneous databases

EvolutionaryTraceiQ9PPP5.
PROiQ9PPP5.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_UREPA
AccessioniPrimary (citable) accession number: Q9PPP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.