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Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Ureaplasma parvum serovar 3 (strain ATCC 700970)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51Glyceraldehyde 3-phosphateBy similarity1
Active sitei86Proton donorBy similarity1
Metal bindingi87Zinc 1; catalyticBy similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi137Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei180Dihydroxyacetone phosphate; via amide nitrogenBy similarity1
Metal bindingi208Zinc 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Synonyms:tsr
Ordered Locus Names:UU596
OrganismiUreaplasma parvum serovar 3 (strain ATCC 700970)
Taxonomic identifieri273119 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeUreaplasma
Proteomesi
  • UP000000423 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001787541 – 290Fructose-bisphosphate aldolaseAdd BLAST290

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi273119.UU596.

Structurei

3D structure databases

ProteinModelPortaliQ9PPP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni209 – 211Dihydroxyacetone phosphate bindingBy similarity3
Regioni230 – 233Dihydroxyacetone phosphate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105D2N. Bacteria.
COG0191. LUCA.
HOGENOMiHOG000227793.
KOiK01624.
OMAiIVRGIKM.

Family and domain databases

CDDicd00947. TBP_aldolase_IIB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000771. FBA_II.
IPR011289. Fruc_bis_ald_class-2.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PPP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLVNAKKM IQNAYENHYA VAAININNLE WIKAALLAAQ ETNSPLLLAT
60 70 80 90 100
SEGAVKYMGG YDNCYAMVVN LIKQMNIKTP VCLHLDHGTY EGCIKAINAG
110 120 130 140 150
YSSIMYDGSK LSIEENIKNT KELLTITKLK GVSVEVEVGS IGGTEDGITS
160 170 180 190 200
EGELANIDDC YQMCLLDIDM LACGIGNIHG IYPKNWKGLN FNLLKEINNK
210 220 230 240 250
VNKPIVLHGG SGISDEQILK AINLGVAKIN INTECQIAFS NALQDHLTKA
260 270 280 290
GDLILSKQYD PRKILAYGVD AIKNTIIDKF TKFNSLNKIK
Length:290
Mass (Da):31,713
Last modified:October 1, 2000 - v1
Checksum:iBD32AB69AE5FE341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF31010.1.
RefSeqiWP_006688794.1. NC_002162.1.

Genome annotation databases

EnsemblBacteriaiAAF31010; AAF31010; UU596.
GeneIDi876119.
KEGGiuur:UU596.
PATRICi20534829. VBIUrePar45146_0619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222894 Genomic DNA. Translation: AAF31010.1.
RefSeqiWP_006688794.1. NC_002162.1.

3D structure databases

ProteinModelPortaliQ9PPP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273119.UU596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF31010; AAF31010; UU596.
GeneIDi876119.
KEGGiuur:UU596.
PATRICi20534829. VBIUrePar45146_0619.

Phylogenomic databases

eggNOGiENOG4105D2N. Bacteria.
COG0191. LUCA.
HOGENOMiHOG000227793.
KOiK01624.
OMAiIVRGIKM.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Family and domain databases

CDDicd00947. TBP_aldolase_IIB. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000771. FBA_II.
IPR011289. Fruc_bis_ald_class-2.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01859. fruc_bis_ald_. 1 hit.
PROSITEiPS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALF_UREPA
AccessioniPrimary (citable) accession number: Q9PPP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.