Q9PPL8 (ACKA_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	Cj0689

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Acetate kinase HAMAP MF_00020		PRO_0000107541

Sequences

	Sequence		Length	Mass (Da)
	Q9PPL8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: EAA704EB7465AF59	FASTA	396	44,057
	10 20 30 40 50 60 MKILVLNSGS SSIKFKFFDN KVVKASGLVE KIGEQNSKVV LKNTLNNESF ERELTINNHE 70 80 90 100 110 120 EGLSIVNELF KESGILADLN ALDGCGHRIV HGGRNLSEHC LVDDYVLKEI DRVSIFAPLH 130 140 150 160 170 180 NPAHLAGIKT MIKAAPSVAN AAIFDTAFHR TMPDFAYMYA LPYDFYDKHN IRRYGFHGTS 190 200 210 220 230 240 HAYVSSRAAK FLQKDQNELN VISAHLGNGA SVCAIEKGKS VDTSMGFTPL EGLVMGTRCG 250 260 270 280 290 300 DLDPAILPFI SHLKGLTIEE IDTLMNKKSG VYGICGYNDF RDIEREIEQG NDKARLALDM 310 320 330 340 350 360 FCYRLVKYIG SYFAVLPKTD AIIFTGGIGE NDSLVRQKVC ERLAHLGIEL DFELNKQRIS 370 380 390 GERMINHANS KVKVLVIPTD EELEIARITE ELIGKN

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL34826.1.
PIR	D81339.
RefSeq	YP_002344107.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PPL8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PPL8. 5 interactions.
Proteomic databases
PRIDE	Q9PPL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	905008.
GenomeReviews	Gene locus Cj0689 in contig AL111168_GR.
KEGG	cje:Cj0689.
PATRIC	20058324. VBICamJej33762_0681.
Phylogenomic databases
HOGENOM	HBG285863.
OMA	ERMINHA.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ0689-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CAMJE

Accession

Primary (citable) accession number: Q9PPL8
Secondary accession number(s): Q0PAJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program