Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isoprenyl transferase

Gene

uppS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121By similarity
Metal bindingi12 – 121MagnesiumBy similarity
Binding sitei17 – 171SubstrateBy similarity
Active sitei60 – 601Proton acceptorBy similarity
Binding sitei61 – 611SubstrateBy similarity
Binding sitei63 – 631SubstrateBy similarity
Binding sitei171 – 1711Substrate1 Publication
Metal bindingi190 – 1901MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-798-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase (EC:2.5.1.-)
Gene namesi
Name:uppS
Ordered Locus Names:Cj0824
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Isoprenyl transferasePRO_0000123587Add
BLAST

Proteomic databases

PaxDbiQ9PP99.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiQ9PP99. 11 interactions.
STRINGi192222.Cj0824.

Structurei

Secondary structure

1
222
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 116Combined sources
Helixi31 – 4515Combined sources
Beta strandi50 – 589Combined sources
Helixi59 – 624Combined sources
Helixi65 – 8521Combined sources
Turni87 – 904Combined sources
Beta strandi91 – 977Combined sources
Helixi99 – 1013Combined sources
Helixi104 – 11714Combined sources
Beta strandi122 – 13110Combined sources
Helixi133 – 14614Combined sources
Helixi153 – 1586Combined sources
Beta strandi160 – 1623Combined sources
Beta strandi167 – 1748Combined sources
Turni183 – 1886Combined sources
Beta strandi190 – 1945Combined sources
Helixi203 – 21513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UGSX-ray2.46A/B1-222[»]
ProteinModelPortaliQ9PP99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 164Substrate binding
Regioni57 – 593Substrate binding
Regioni177 – 1793Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the UPP synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiISAFNQR.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PP99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELKHLAVV MDGNRRWARA KGFLAKLGYS QGVKTMQKLM EVCMEENISN
60 70 80 90 100
LSLFAFSTEN WKRPKDEIDF IFELLDRCLD EALEKFEKNN VRLRAIGDLS
110 120 130 140 150
RLEDKVREKI TLVEEKTKHC DALCVNLAIS YGARDEIIRA AKRVIEKKLE
160 170 180 190 200
LNEENLTQNL DLPLDVDLML RVGNAKRLSN FLLWQCSYAE IYFSETLFPS
210 220
LTKREFKRII KEFRNRERTF GK
Length:222
Mass (Da):26,087
Last modified:October 1, 2000 - v1
Checksum:iD8F42F7967EA8712
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34952.1.
PIRiH81354.
RefSeqiWP_002852565.1. NC_002163.1.
YP_002344231.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34952; CAL34952; Cj0824.
GeneIDi905127.
KEGGicje:Cj0824.
PATRICi20058596. VBICamJej33762_0812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34952.1.
PIRiH81354.
RefSeqiWP_002852565.1. NC_002163.1.
YP_002344231.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UGSX-ray2.46A/B1-222[»]
ProteinModelPortaliQ9PP99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PP99. 11 interactions.
STRINGi192222.Cj0824.

Proteomic databases

PaxDbiQ9PP99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL34952; CAL34952; Cj0824.
GeneIDi905127.
KEGGicje:Cj0824.
PATRICi20058596. VBICamJej33762_0812.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiISAFNQR.

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-798-MONOMER.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT_CAMJE
AccessioniPrimary (citable) accession number: Q9PP99
Secondary accession number(s): Q0PA66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.