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Protein

Isoprenyl transferase

Gene

uppS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.By similarity

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei12By similarity1
Metal bindingi12MagnesiumBy similarity1
Binding sitei17SubstrateBy similarity1
Active sitei60Proton acceptorBy similarity1
Binding sitei61SubstrateBy similarity1
Binding sitei63SubstrateBy similarity1
Binding sitei171Substrate1 Publication1
Metal bindingi190MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase (EC:2.5.1.-)
Gene namesi
Name:uppS
Ordered Locus Names:Cj0824
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001235871 – 222Isoprenyl transferaseAdd BLAST222

Proteomic databases

PaxDbiQ9PP99.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

IntActiQ9PP99. 11 interactors.
STRINGi192222.Cj0824.

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Helixi31 – 45Combined sources15
Beta strandi50 – 58Combined sources9
Helixi59 – 62Combined sources4
Helixi65 – 85Combined sources21
Turni87 – 90Combined sources4
Beta strandi91 – 97Combined sources7
Helixi99 – 101Combined sources3
Helixi104 – 117Combined sources14
Beta strandi122 – 131Combined sources10
Helixi133 – 146Combined sources14
Helixi153 – 158Combined sources6
Beta strandi160 – 162Combined sources3
Beta strandi167 – 174Combined sources8
Turni183 – 188Combined sources6
Beta strandi190 – 194Combined sources5
Helixi203 – 215Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UGSX-ray2.46A/B1-222[»]
ProteinModelPortaliQ9PP99.
SMRiQ9PP99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 16Substrate binding4
Regioni57 – 59Substrate binding3
Regioni177 – 179Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the UPP synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiISAFNQR.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PP99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELKHLAVV MDGNRRWARA KGFLAKLGYS QGVKTMQKLM EVCMEENISN
60 70 80 90 100
LSLFAFSTEN WKRPKDEIDF IFELLDRCLD EALEKFEKNN VRLRAIGDLS
110 120 130 140 150
RLEDKVREKI TLVEEKTKHC DALCVNLAIS YGARDEIIRA AKRVIEKKLE
160 170 180 190 200
LNEENLTQNL DLPLDVDLML RVGNAKRLSN FLLWQCSYAE IYFSETLFPS
210 220
LTKREFKRII KEFRNRERTF GK
Length:222
Mass (Da):26,087
Last modified:October 1, 2000 - v1
Checksum:iD8F42F7967EA8712
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34952.1.
PIRiH81354.
RefSeqiWP_002852565.1. NC_002163.1.
YP_002344231.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL34952; CAL34952; Cj0824.
GeneIDi905127.
KEGGicje:Cj0824.
PATRICi20058596. VBICamJej33762_0812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL34952.1.
PIRiH81354.
RefSeqiWP_002852565.1. NC_002163.1.
YP_002344231.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UGSX-ray2.46A/B1-222[»]
ProteinModelPortaliQ9PP99.
SMRiQ9PP99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PP99. 11 interactors.
STRINGi192222.Cj0824.

Proteomic databases

PaxDbiQ9PP99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL34952; CAL34952; Cj0824.
GeneIDi905127.
KEGGicje:Cj0824.
PATRICi20058596. VBICamJej33762_0812.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiISAFNQR.

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-765-MONOMER.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT_CAMJE
AccessioniPrimary (citable) accession number: Q9PP99
Secondary accession number(s): Q0PA66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.