Q9PP06 (APT_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase
Short name=APRT
EC=2.4.2.7

Gene names

Name:	apt
Ordered Locus Names:	Cj0927

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]

Taxonomic identifier

192222 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	182 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	AMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway adenine salvage Inferred from electronic annotation. Source: HAMAP purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 182	182	Adenine phosphoribosyltransferase HAMAP-Rule MF_00004		PRO_0000149368

Sequences

	Sequence		Length	Mass (Da)
	Q9PP06 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 96C575308263D94A	FASTA	182	20,671
	10 20 30 40 50 60 MIKLTQEEQK YLLDSIRIIP DFPKKGIIFR DITTLLNNKE ALNFLLKHLK ERYKDYNLDF 70 80 90 100 110 120 IAGTESRGFI FASMICAKLN LPFVPIRKPG KLPFETFSCE YDLEYGSDKV ELHKDAFKNI 130 140 150 160 170 180 QNARVLLVDD LIATGGTAIA SYELIQKAGA KCVEACFLIN LKDLNGANKL EKLTSVYSVL EI

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL35047.1.
PIR	F81366.
RefSeq	YP_002344325.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PP06.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PP06. 13 interactions.
STRING	192222.Cj0927.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL35047; CAL35047; Cj0927.
GeneID	905205.
KEGG	cje:Cj0927.
PATRIC	20058798. VBICamJej33762_0911.
Phylogenomic databases
eggNOG	COG0503.
HOGENOM	HOG000036776.
KO	K00759.
OMA	DYALEYG.
ProtClustDB	PRK02304.
Enzyme and pathway databases
BioCyc	CJEJ192222:GJTS-895-MONOMER.
UniPathway	UPA00588; UER00646.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr.
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase_dom. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01090. apt. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT_CAMJE

Accession

Primary (citable) accession number: Q9PP06
Secondary accession number(s): Q0P9X2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program