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Q9PP06 (APT_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenine phosphoribosyltransferase

Short name=APRT
EC=2.4.2.7
Gene names
Name:apt
Ordered Locus Names:Cj0927
OrganismCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]
Taxonomic identifier192222 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004

Catalytic activity

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00004

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00004.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processAMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

adenine salvage

Inferred from electronic annotation. Source: InterPro

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Adenine phosphoribosyltransferase HAMAP-Rule MF_00004
PRO_0000149368

Sequences

Sequence LengthMass (Da)Tools
Q9PP06 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 96C575308263D94A

FASTA18220,671
        10         20         30         40         50         60 
MIKLTQEEQK YLLDSIRIIP DFPKKGIIFR DITTLLNNKE ALNFLLKHLK ERYKDYNLDF 

        70         80         90        100        110        120 
IAGTESRGFI FASMICAKLN LPFVPIRKPG KLPFETFSCE YDLEYGSDKV ELHKDAFKNI 

       130        140        150        160        170        180 
QNARVLLVDD LIATGGTAIA SYELIQKAGA KCVEACFLIN LKDLNGANKL EKLTSVYSVL 


EI 

« Hide

References

[1]"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences."
Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. expand/collapse author list , van Vliet A.H.M., Whitehead S., Barrell B.G.
Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 11168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL111168 Genomic DNA. Translation: CAL35047.1.
PIRF81366.
RefSeqYP_002344325.1. NC_002163.1.

3D structure databases

ProteinModelPortalQ9PP06.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9PP06. 13 interactions.
STRING192222.Cj0927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL35047; CAL35047; Cj0927.
GeneID905205.
KEGGcje:Cj0927.
PATRIC20058798. VBICamJej33762_0911.

Phylogenomic databases

eggNOGCOG0503.
HOGENOMHOG000036776.
KOK00759.
OMAYGLEYGK.
OrthoDBEOG6T4S55.
ProtClustDBPRK02304.

Enzyme and pathway databases

BioCycCJEJ192222:GJTS-895-MONOMER.
UniPathwayUPA00588; UER00646.

Family and domain databases

HAMAPMF_00004. Aden_phosphoribosyltr.
InterProIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01090. apt. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPT_CAMJE
AccessionPrimary (citable) accession number: Q9PP06
Secondary accession number(s): Q0P9X2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways