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Q9PNY2

- PUR9_CAMJE

UniProt

Q9PNY2 - PUR9_CAMJE

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, Cj0953c
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-928-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Cj0953c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_0000192079Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ9PNY2. 1 interaction.
STRINGi192222.Cj0953c.

Structurei

Secondary structure

1
510
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 98
Helixi13 – 2210
Beta strandi26 – 294
Helixi31 – 399
Beta strandi91 – 999
Helixi103 – 1097
Helixi113 – 1186
Helixi124 – 13310
Turni134 – 1374
Beta strandi139 – 1413
Helixi144 – 1463
Helixi147 – 1559
Helixi161 – 19030
Beta strandi196 – 20914
Beta strandi211 – 2133
Beta strandi218 – 2258
Helixi226 – 2305
Beta strandi232 – 2365
Helixi240 – 25314
Beta strandi261 – 2666
Beta strandi269 – 2757
Helixi279 – 2879
Helixi291 – 2944
Beta strandi298 – 3058
Helixi307 – 3137
Beta strandi319 – 3268
Helixi328 – 3325
Beta strandi341 – 3444
Beta strandi346 – 3494
Beta strandi356 – 3627
Beta strandi365 – 3706
Turni376 – 3816
Beta strandi382 – 3843
Beta strandi386 – 3883
Helixi392 – 40716
Beta strandi413 – 4175
Beta strandi420 – 4256
Beta strandi427 – 4293
Helixi431 – 44414
Beta strandi453 – 4553
Helixi464 – 4718
Beta strandi476 – 4794
Helixi486 – 49611
Beta strandi499 – 5024

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EHIX-ray2.28A/B1-510[»]
ProteinModelPortaliQ9PNY2.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PNY2-1 [UniParc]FASTAAdd to Basket

« Hide

MRALLSVSDK EGIVEFGKEL ENLGFEILST GGTFKLLKEN GIKVIEVSDF    50
TKSPELFEGR VKTLHPKIHG GILHKRSDEN HIKQAKENEI LGIDLVCVNL 100
YPFKKTTIMS DDFDEIIENI DIGGPAMIRS AAKNYKDVMV LCDPLDYEKV 150
IETLKKGQND ENFRLNLMIK AYEHTANYDA YIANYMNERF NGGFGASKFI 200
VGQKVFDTKY GENPHQKGAL YEFDAFFSAN FKALKGEASF NNLTDINAAL 250
NLASSFDKAP AIAIVKHGNP CGFAIKENLV QSYIHALKCD SVSAYGGVVA 300
INGTLDEALA NKINEIYVEV IIAANVDEKA LAVFEGKKRI KIFTQESPFL 350
IRSFDKYDFK HIDGGFVYQN SDEVGEDELK NAKLMSQREA SKEELKDLEI 400
AMKIAAFTKS NNVVYVKNGA MVAIGMGMTS RIDAAKAAIA KAKEMGLDLQ 450
GCVLASEAFF PFRDSIDEAS KVGVKAIVEP GGSIRDDEVV KAADEYGMAL 500
YFTGVRHFLH 510
Length:510
Mass (Da):56,402
Last modified:October 1, 2000 - v1
Checksum:i56F356F04B3A2092
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL35073.1.
PIRiH81369.
RefSeqiYP_002344351.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35073; CAL35073; Cj0953c.
GeneIDi905247.
KEGGicje:Cj0953c.
PATRICi20058866. VBICamJej33762_0937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL111168 Genomic DNA. Translation: CAL35073.1 .
PIRi H81369.
RefSeqi YP_002344351.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EHI X-ray 2.28 A/B 1-510 [» ]
ProteinModelPortali Q9PNY2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PNY2. 1 interaction.
STRINGi 192222.Cj0953c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL35073 ; CAL35073 ; Cj0953c .
GeneIDi 905247.
KEGGi cje:Cj0953c.
PATRICi 20058866. VBICamJej33762_0937.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CJEJ192222:GJTS-928-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiPUR9_CAMJE
AccessioniPrimary (citable) accession number: Q9PNY2
Secondary accession number(s): Q0P9U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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