Reviewed,
UniProtKB/Swiss-Prot Q9PNY2 (PUR9_CAMJE)
Last modified
February 9, 2010.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional purine biosynthesis protein purH Including the following 2 domains: 1- Recommended name: Phosphoribosylaminoimidazolecarboxamide formyltransferase EC=2.1.2.3 Alternative name(s): AICAR transformylase 2- Recommended name: IMP cyclohydrolase EC=3.5.4.10 Alternative name(s): Inosinicase IMP synthetase ATIC | ||||
| Gene names |
| ||||
| Organism | Campylobacter jejuni [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 197 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 510 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP MF_00139 |
| Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP MF_00139 |
| Domain | The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP MF_00139 |
| Sequence similarities | Belongs to the purH family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Hydrolase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
| Gene Ontology (GO) | |
| Biological process | IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | IMP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP phosphoribosylaminoimidazolecarboxamide formyltransferase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 510 | 510 | Bifunctional purine biosynthesis protein purH HAMAP MF_00139 | PRO_0000192079 | |||
Sequences
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References
| [1] | "The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. Barrell B.G.Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL111168 Genomic DNA. Translation: CAL35073.1. |
| PIR | H81369. |
| RefSeq | YP_002344351.1. |
3D structure databases | |
| SMR | Q9PNY2. Positions 2-510. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9PNY2. 1 interaction. |
Genome annotation databases | |
| GeneID | 905247. |
| GenomeReviews | Gene locus Cj0953c in contig AL111168_GR. |
| KEGG | cje:Cj0953c. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG498048. |
| OMA | VVKHVKS. |
Enzyme and pathway databases | |
| BioCyc | CJEJ192222:CJ0953C-MONOMER. |
| BRENDA | 2.1.2.3. 255835. 3.5.4.10. 255835. |
Family and domain databases | |
| HAMAP | MF_00139. PurH. [Tree] |
| InterPro | IPR002695. AICARFT_IMPCHas. IPR013982. AICARFT_IMPCHase_bienz. IPR011607. MGS. [Graphical view] |
| PANTHER | PTHR11692. AICARFT_IMPCHas. 1 hit. |
| Pfam | PF01808. AICARFT_IMPCHas. 1 hit. PF02142. MGS. 1 hit. [Graphical view] |
| PIRSF | PIRSF000414. AICARFT_IMPCHas. 1 hit. |
| SMART | SM00798. AICARFT_IMPCHas. 1 hit. SM00851. MGS. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00355. purH. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR9_CAMJE | ||||||||
| Accession | Primary (citable) accession number: Q9PNY2 Secondary accession number(s): Q0P9U6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


