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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1102-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Cj1175c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002420011 – 530Arginine--tRNA ligaseAdd BLAST530

Proteomic databases

PaxDbiQ9PNC0.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PNC0. 3 interactors.
STRINGi192222.Cj1175c.

Structurei

Secondary structure

1530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi79 – 91Combined sources13
Helixi93 – 95Combined sources3
Beta strandi105 – 109Combined sources5
Beta strandi115 – 118Combined sources4
Helixi121 – 123Combined sources3
Helixi124 – 139Combined sources16
Beta strandi143 – 150Combined sources8
Helixi154 – 171Combined sources18
Helixi187 – 200Combined sources14
Helixi202 – 204Combined sources3
Helixi207 – 209Combined sources3
Helixi210 – 231Combined sources22
Beta strandi239 – 241Combined sources3
Helixi242 – 245Combined sources4
Helixi249 – 258Combined sources10
Beta strandi262 – 265Combined sources4
Beta strandi268 – 271Combined sources4
Helixi273 – 276Combined sources4
Beta strandi282 – 285Combined sources4
Helixi293 – 305Combined sources13
Beta strandi310 – 317Combined sources8
Helixi318 – 323Combined sources6
Helixi324 – 332Combined sources9
Turni333 – 335Combined sources3
Helixi338 – 340Combined sources3
Beta strandi341 – 346Combined sources6
Beta strandi349 – 353Combined sources5
Helixi370 – 377Combined sources8
Helixi379 – 385Combined sources7
Beta strandi395 – 398Combined sources4
Helixi399 – 403Combined sources5
Helixi410 – 427Combined sources18
Turni432 – 434Combined sources3
Helixi445 – 455Combined sources11
Helixi457 – 467Combined sources11
Helixi472 – 490Combined sources19
Helixi499 – 519Combined sources21

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FNRX-ray2.20A77-530[»]
ProteinModelPortaliQ9PNC0.
SMRiQ9PNC0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9PNC0.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi113 – 123"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
HOGENOMiHOG000247214.
KOiK01887.
OMAiQDLIYHL.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PNC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSIIFNEIK KILECDFALE NPKDKNLAHF ATPLAFSLAK ELKKSPMLIA
60 70 80 90 100
SDLASKFQNH DCFESVEAVN GYLNFRISKT FLNELANQAL TNPNDFTKGE
110 120 130 140 150
KKQESFLLEY VSANPTGPLH IGHARGAVFG DTLTRLARHL GYKFNTEYYV
160 170 180 190 200
NDAGNQIYLL GLSILLSVKE SILHENVEYP EQYYKGEYIV DLAKEAFEKF
210 220 230 240 250
GKEFFSEENI PSLADWAKDK MLVLIKQNLE QAKIKIDSYV SERSYYDALN
260 270 280 290 300
ATLESLKEHK GIYEQEGKIW LASSQKGDEK DRVIIREDGR GTYLAADIVY
310 320 330 340 350
HKDKMSRGYG KCINIWGADH HGYIPRMKAA MEFLGFDSNN LEIILAQMVS
360 370 380 390 400
LLKDGEPYKM SKRAGNFILM SDVVDEIGSD ALRYIFLSKK CDTHLEFDIS
410 420 430 440 450
DLQKEDSSNP VYYINYAHAR IHQVFAKAGK KIDDVMKADL QSLNQDGVNL
460 470 480 490 500
LFEALNLKAV LNDAFEARAL QKIPDYLKNL AANFHKFYNE NKVVGSANEN
510 520 530
DLLKLFSLVA LSIKTAFSLM GIEAKNKMEH
Length:530
Mass (Da):60,190
Last modified:October 1, 2000 - v1
Checksum:iD2C9B35AF857B2B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35290.1.
PIRiA81323.
RefSeqiWP_010891916.1. NC_002163.1.
YP_002344566.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35290; CAL35290; Cj1175c.
GeneIDi905465.
KEGGicje:Cj1175c.
PATRICi20059306. VBICamJej33762_1156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35290.1.
PIRiA81323.
RefSeqiWP_010891916.1. NC_002163.1.
YP_002344566.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FNRX-ray2.20A77-530[»]
ProteinModelPortaliQ9PNC0.
SMRiQ9PNC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PNC0. 3 interactors.
STRINGi192222.Cj1175c.

Proteomic databases

PaxDbiQ9PNC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL35290; CAL35290; Cj1175c.
GeneIDi905465.
KEGGicje:Cj1175c.
PATRICi20059306. VBICamJej33762_1156.

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
HOGENOMiHOG000247214.
KOiK01887.
OMAiQDLIYHL.

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1102-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9PNC0.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYR_CAMJE
AccessioniPrimary (citable) accession number: Q9PNC0
Secondary accession number(s): Q0P981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.