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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1146-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Cj1175c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Arginine--tRNA ligasePRO_0000242001Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PNC0. 3 interactions.
STRINGi192222.Cj1175c.

Structurei

Secondary structure

1
530
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi79 – 9113Combined sources
Helixi93 – 953Combined sources
Beta strandi105 – 1095Combined sources
Beta strandi115 – 1184Combined sources
Helixi121 – 1233Combined sources
Helixi124 – 13916Combined sources
Beta strandi143 – 1508Combined sources
Helixi154 – 17118Combined sources
Helixi187 – 20014Combined sources
Helixi202 – 2043Combined sources
Helixi207 – 2093Combined sources
Helixi210 – 23122Combined sources
Beta strandi239 – 2413Combined sources
Helixi242 – 2454Combined sources
Helixi249 – 25810Combined sources
Beta strandi262 – 2654Combined sources
Beta strandi268 – 2714Combined sources
Helixi273 – 2764Combined sources
Beta strandi282 – 2854Combined sources
Helixi293 – 30513Combined sources
Beta strandi310 – 3178Combined sources
Helixi318 – 3236Combined sources
Helixi324 – 3329Combined sources
Turni333 – 3353Combined sources
Helixi338 – 3403Combined sources
Beta strandi341 – 3466Combined sources
Beta strandi349 – 3535Combined sources
Helixi370 – 3778Combined sources
Helixi379 – 3857Combined sources
Beta strandi395 – 3984Combined sources
Helixi399 – 4035Combined sources
Helixi410 – 42718Combined sources
Turni432 – 4343Combined sources
Helixi445 – 45511Combined sources
Helixi457 – 46711Combined sources
Helixi472 – 49019Combined sources
Helixi499 – 51921Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FNRX-ray2.20A77-530[»]
ProteinModelPortaliQ9PNC0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9PNC0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi113 – 12311"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiLDTHLEF.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PNC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSIIFNEIK KILECDFALE NPKDKNLAHF ATPLAFSLAK ELKKSPMLIA
60 70 80 90 100
SDLASKFQNH DCFESVEAVN GYLNFRISKT FLNELANQAL TNPNDFTKGE
110 120 130 140 150
KKQESFLLEY VSANPTGPLH IGHARGAVFG DTLTRLARHL GYKFNTEYYV
160 170 180 190 200
NDAGNQIYLL GLSILLSVKE SILHENVEYP EQYYKGEYIV DLAKEAFEKF
210 220 230 240 250
GKEFFSEENI PSLADWAKDK MLVLIKQNLE QAKIKIDSYV SERSYYDALN
260 270 280 290 300
ATLESLKEHK GIYEQEGKIW LASSQKGDEK DRVIIREDGR GTYLAADIVY
310 320 330 340 350
HKDKMSRGYG KCINIWGADH HGYIPRMKAA MEFLGFDSNN LEIILAQMVS
360 370 380 390 400
LLKDGEPYKM SKRAGNFILM SDVVDEIGSD ALRYIFLSKK CDTHLEFDIS
410 420 430 440 450
DLQKEDSSNP VYYINYAHAR IHQVFAKAGK KIDDVMKADL QSLNQDGVNL
460 470 480 490 500
LFEALNLKAV LNDAFEARAL QKIPDYLKNL AANFHKFYNE NKVVGSANEN
510 520 530
DLLKLFSLVA LSIKTAFSLM GIEAKNKMEH
Length:530
Mass (Da):60,190
Last modified:October 1, 2000 - v1
Checksum:iD2C9B35AF857B2B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35290.1.
PIRiA81323.
RefSeqiYP_002344566.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35290; CAL35290; Cj1175c.
GeneIDi905465.
KEGGicje:Cj1175c.
PATRICi20059306. VBICamJej33762_1156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35290.1.
PIRiA81323.
RefSeqiYP_002344566.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FNRX-ray2.20A77-530[»]
ProteinModelPortaliQ9PNC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PNC0. 3 interactions.
STRINGi192222.Cj1175c.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL35290; CAL35290; Cj1175c.
GeneIDi905465.
KEGGicje:Cj1175c.
PATRICi20059306. VBICamJej33762_1156.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiLDTHLEF.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1146-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9PNC0.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiSYR_CAMJE
AccessioniPrimary (citable) accession number: Q9PNC0
Secondary accession number(s): Q0P981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.