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Protein

Guanylate kinase

Gene

gmk

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-1134-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:Cj1177
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705151 – 207Guanylate kinaseAdd BLAST207

Proteomic databases

PaxDbiQ9PNB8
PRIDEiQ9PNB8

Interactioni

Protein-protein interaction databases

IntActiQ9PNB8, 50 interactors
STRINGi192222.Cj1177c

Structurei

3D structure databases

ProteinModelPortaliQ9PNB8
SMRiQ9PNB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 185Guanylate kinase-likeAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
HOGENOMiHOG000037638
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PNB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQGFVLLI SGPSGAGKST LLKKLFDEFE DELYFSISST TRKPREGEKN
60 70 80 90 100
GIHYHFISHE EFQKGIDSDH FLEWARVHEN FYGTSLKHTQ NALDNGKIVV
110 120 130 140 150
FDIDVQGFKI ARKKMADKIV SVFITTKNKD ELKKRLIKRN TDTIIQLEKR
160 170 180 190 200
LQNASDEMKE LSEYDYLIIN DELKQSYEAL RAILIAHKFR TKGQNLGQIQ

NIWNEGE
Length:207
Mass (Da):24,025
Last modified:October 1, 2000 - v1
Checksum:iF258896CD6EE1AC2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81F → V in CAA04292 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL35292.1
AJ000744 Genomic DNA Translation: CAA04292.1
PIRiC81323
RefSeqiWP_002860253.1, NC_002163.1
YP_002344568.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL35292; CAL35292; Cj1177c
GeneIDi905467
KEGGicje:Cj1177c
PATRICifig|192222.6.peg.1158

Similar proteinsi

Entry informationi

Entry nameiKGUA_CAMJE
AccessioniPrimary (citable) accession number: Q9PNB8
Secondary accession number(s): O32356, Q0P979
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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