Q9PNB8 (KGUA_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Cj1177

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Guanylate kinase HAMAP MF_00328		PRO_0000170515
Regions
	Domain	5 – 185	181	Guanylate kinase-like
	Nucleotide binding	12 – 19	8	ATP By similarity
Experimental info
	Sequence conflict	81	1	F → V in CAA04292. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9PNB8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F258896CD6EE1AC2	FASTA	207	24,025
	10 20 30 40 50 60 MKLQGFVLLI SGPSGAGKST LLKKLFDEFE DELYFSISST TRKPREGEKN GIHYHFISHE 70 80 90 100 110 120 EFQKGIDSDH FLEWARVHEN FYGTSLKHTQ NALDNGKIVV FDIDVQGFKI ARKKMADKIV 130 140 150 160 170 180 SVFITTKNKD ELKKRLIKRN TDTIIQLEKR LQNASDEMKE LSEYDYLIIN DELKQSYEAL 190 200 RAILIAHKFR TKGQNLGQIQ NIWNEGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.
[2]	Karlyshev A.V., Wren B.W. Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-126. Strain: NCTC 11168 / Serotype O:2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL35292.1. AJ000744 Genomic DNA. Translation: CAA04292.1.
PIR	C81323.
RefSeq	YP_002344568.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PNB8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PNB8. 52 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	905467.
GenomeReviews	Gene locus Cj1177 in contig AL111168_GR.
PATRIC	20059310. VBICamJej33762_1158.
Phylogenomic databases
HOGENOM	HBG671982.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ1177C-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. Guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CAMJE

Accession

Primary (citable) accession number: Q9PNB8
Secondary accession number(s): O32356, Q0P979

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program