Q9PN54 (DCUP_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Cj1243

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm Probable HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_0000187591
Regions
	Region	21 – 25	5	Substrate binding By similarity
Sites
	Binding site	40	1	Substrate By similarity
	Binding site	71	1	Substrate By similarity
	Binding site	148	1	Substrate By similarity
	Binding site	203	1	Substrate By similarity
	Binding site	316	1	Substrate By similarity
	Site	71	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PN54 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 44137F84547C9FEC	FASTA	340	38,922
	10 20 30 40 50 60 MIFIDACFKK PTPYTPIWMM RQAGRYLPEY MEVRKQAGDF LSLCKDYKKA SEVSLQPIDI 70 80 90 100 110 120 LDVDAAIIFS DILVVPLEMG MNLRFEKGEG PVFGNPISTL EDLEKLDDQN AHKKLNYVYD 130 140 150 160 170 180 ALKLTREKLS QNKALIGFCG SPWTIATYMI EGSGSKNYAK CKKMLYQNPE LLHKILNKLT 190 200 210 220 230 240 QVLKLYLEEQ IKAGANAIQI FDSWASALEY DKFFEFSFNY MLEISNFIKS KYPNIPVILF 250 260 270 280 290 300 PKGISGYLDR IDGNFDVFGV DWSTPLDLAR DKLSHKYTLQ GNMEPCRLYD KNAIKEGVEK 310 320 330 340 ILKTMQNKAH IFNLGHGILP DIPVENAKYF IKLVQESSAK

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL35358.1.
PIR	E81331.
RefSeq	YP_002344634.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PN54.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PN54. 7 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	905534.
GenomeReviews	Gene locus Cj1243 in contig AL111168_GR.
KEGG	cje:Cj1243.
PATRIC	20059446. VBICamJej33762_1225.
Phylogenomic databases
HOGENOM	HBG628392.
OMA	PRIHFGV.
ProtClustDB	PRK00115.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ1243-MONOMER.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_CAMJE

Accession

Primary (citable) accession number: Q9PN54
Secondary accession number(s): Q0P913

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program