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Protein

dCTP deaminase

Gene

dcd

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei152dCTPUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei176dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 112dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-1251-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:Cj1292
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559721 – 186dCTP deaminaseAdd BLAST186

Proteomic databases

PaxDbiQ9PN07
PRIDEiQ9PN07

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
Cj1374cQ9PMS63EBI-1271615,EBI-1271444

Protein-protein interaction databases

IntActiQ9PN07, 18 interactors
STRINGi192222.Cj1292

Chemistry databases

BindingDBiQ9PN07

Structurei

3D structure databases

ProteinModelPortaliQ9PN07
SMRiQ9PN07
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228600
KOiK01494
OMAiGQLCLFR

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PN07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKADNWIR KMALEHKMIE PFCEANIGKG VVSYGLSSYG YDIRVGREFK
60 70 80 90 100
IFTNVNSTVV DPKNFVEENV VDFEGDVCIV PANSFALART IEYFKMPDNV
110 120 130 140 150
LAICLGKSTY ARCGIIVNVT PFEPGFEGHI TIEISNTTPL PAKIYANEGI
160 170 180
AQVLFLQGDE KCDTTYKDKK GKYQAQTGIT LPRILK
Length:186
Mass (Da):20,699
Last modified:October 1, 2000 - v1
Checksum:i68DC660FB28FD33C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL35406.1
PIRiA81272
RefSeqiWP_002854086.1, NC_002163.1
YP_002344682.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL35406; CAL35406; Cj1292
GeneIDi905584
KEGGicje:Cj1292
PATRICifig|192222.6.peg.1274

Similar proteinsi

Entry informationi

Entry nameiDCD_CAMJE
AccessioniPrimary (citable) accession number: Q9PN07
Secondary accession number(s): Q0P8W5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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