Q9PN07 (DCD_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	Cj1292

Organism

Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168) [Reference proteome] [HAMAP]

Taxonomic identifier

192222 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter › Campylobacter jejuni › Campylobacter jejuni subsp. jejuni

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Cj1374c	Q9PMS6	3	EBI-1271615,EBI-1271444

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_0000155972

Sequences

	Sequence		Length	Mass (Da)
	Q9PN07 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 68DC660FB28FD33C	FASTA	186	20,699
	10 20 30 40 50 60 MGLKADNWIR KMALEHKMIE PFCEANIGKG VVSYGLSSYG YDIRVGREFK IFTNVNSTVV 70 80 90 100 110 120 DPKNFVEENV VDFEGDVCIV PANSFALART IEYFKMPDNV LAICLGKSTY ARCGIIVNVT 130 140 150 160 170 180 PFEPGFEGHI TIEISNTTPL PAKIYANEGI AQVLFLQGDE KCDTTYKDKK GKYQAQTGIT LPRILK

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL35406.1.
PIR	A81272.
RefSeq	YP_002344682.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PN07.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PN07. 18 interactions.
STRING	192222.Cj1292.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAL35406; CAL35406; Cj1292.
GeneID	905584.
KEGG	cje:Cj1292.
PATRIC	20059548. VBICamJej33762_1274.
Phylogenomic databases
eggNOG	COG0717.
HOGENOM	HOG000228600.
KO	K01494.
OMA	RSVLTVC.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	CJEJ192222:GJTS-1265-MONOMER.
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_CAMJE

Accession

Primary (citable) accession number: Q9PN07
Secondary accession number(s): Q0P8W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program