Q9PMZ6 (FABHL_CAMJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180

Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III

Gene names

Ordered Locus Names:

Cj1303

Organism

Campylobacter jejuni

Taxonomic identifier

197 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May catalyze the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity. HAMAP MF_01815
Catalytic activity	Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815
Subunit structure	Homodimer By similarity. HAMAP MF_01815
Subcellular location	Cytoplasm Probable HAMAP MF_01815.
Sequence similarities	Belongs to the FabH family.
Caution	Lacks the Asn-Xaa-Arg residues, which are typical of the ACP-binding site and are essential for the association between AcpP and FabH.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: InterPro beta-ketoacyl-acyl-carrier-protein synthase III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Putative 3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815		PRO_0000110520
Sites
	Active site	122	1	By similarity
	Active site	268	1	By similarity
	Active site	299	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PMZ6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B865A6A8637A8E37	FASTA	353	39,480
	10 20 30 40 50 60 MKTRFDKAKI SGICVSVPEH KICIDDELES VFSNDIKTLK RMKKVIGLNT RYICDENTCV 70 80 90 100 110 120 SDLGKHAANT LLQGLNIDKN SLDALIVVTQ SPDFFMPSTA CYLHQLLNLS SKTVAFDLGQ 130 140 150 160 170 180 ACAGYLYGLF VAHSLIQSGL GKILLICGDT LSKFIHPKNM NLAPIFGDGV SATLIEKTDF 190 200 210 220 230 240 NEAFFELGSD GKYFDKLIIP KGAMRIPKAD IFNDDSLMQT EEFRQLENLY MDGANIFNMA 250 260 270 280 290 300 LECEPKSFKE ILEFSKVDEK DIAFHLFHQS NAYLVDCIKE ELKLNDDKVP NFIMEKYANL 310 320 330 340 350 SACSLPTLLC ELDTPKEFKA SLSAFGAGLS WGSAVLNFKD LYTKNILIYT KEK

References

[1]

"The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences." Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M., Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S., Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A., Rajandream M.A., Rutherford K.M. , van Vliet A.H.M., Whitehead S., Barrell B.G. Nature 403:665-668(2000) [PubMed: 10688204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCTC 11168 / Serotype O:2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL111168 Genomic DNA. Translation: CAL35417.1.
PIR	D81273.
RefSeq	YP_002344693.1. NC_002163.1.
3D structure databases
ProteinModelPortal	Q9PMZ6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9PMZ6. 41 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	905595.
GenomeReviews	Gene locus Cj1303 in contig AL111168_GR.
KEGG	cje:Cj1303.
PATRIC	20059570. VBICamJej33762_1285.
Phylogenomic databases
HOGENOM	HBG649927.
OMA	DINLGCS.
ProtClustDB	PRK12880.
Enzyme and pathway databases
BioCyc	CJEJ192222:CJ1303-MONOMER.
Family and domain databases
HAMAP	MF_01815. FabH. Divergent sequence. [Tree]
InterPro	IPR013751. ACP_syn_III. IPR013747. ACP_syn_III_C. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 3 hits.
KO	K00648.
Pfam	PF08545. ACP_syn_III. 1 hit. PF08541. ACP_syn_III_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 2 hits.
ProtoNet	Search...

Entry information

Entry name

FABHL_CAMJE

Accession

Primary (citable) accession number: Q9PMZ6
Secondary accession number(s): Q0P8V4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program