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Q9PMT4

- GLMS_CAMJE

UniProt

Q9PMT4 - GLMS_CAMJE

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei593 – 5931For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:Cj1366c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000799: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135314Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PMT4. 29 interactions.
STRINGi192222.Cj1366c.

Structurei

3D structure databases

ProteinModelPortaliQ9PMT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini277 – 421145SIS 1UniRule annotationAdd
BLAST
Domaini450 – 588139SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSAGICTL.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PMT4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYIGN NEKKQIILNG LKELEYRGYD SAGMAVMQEG ELSFFKAVGK
60 70 80 90 100
LENLANKCTD FESQGYGFAI GHTRWATHGK PTEINAHPHL GQYSCVIHNG
110 120 130 140 150
IIENYKEIKD KLEKEGVSFL SQTDTEVIVQ LFEFYARNLG VFEAWQKTIK
160 170 180 190 200
ELRGAFATLL VTKKDPNHVY FAKNAAPLII GKNANKEWYF SSGDAPLIGS
210 220 230 240 250
CDEVMYLEDL SLGYASKDEL VVYENDILKS LCFSKLSGDK AYAKKDGFRF
260 270 280 290 300
FMEKEIYEQS RVMSEVLMGR IQGDEVVFDE LNNEDLSQVD EITLCACGTS
310 320 330 340 350
YHAAMASAYL FERIAKVKAK VEIASEFRYR EAIIKKDSLF IVISQSGETA
360 370 380 390 400
DTLEALKIAK EQGAKTFAIC NVDNSNIVRL AHLSLLTRAG IEKGVASTKA
410 420 430 440 450
FATQVLTLWM LAIFMAQKRN LNVSAEIKAL LHTPNCVSVK QALHEKIHRL
460 470 480 490 500
SKRYLDGHGF FFIGRDVFYP LALEGALKLK ELSYLHAEGY PAGEMKHGPI
510 520 530 540 550
ALADSKLYTI ALMPKHMLYE KTKSNVEELI ARDSTVLSIS PLEFDLSDDF
560 570 580 590
IKTNEQDHYM CEFFEMMVIT QLLAMEISIR LGNDVDMPRN LAKSVTVE
Length:598
Mass (Da):67,188
Last modified:January 23, 2007 - v3
Checksum:i9147183C44D594B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35478.1.
PIRiC81281.
RefSeqiYP_002344754.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35478; CAL35478; Cj1366c.
GeneIDi905659.
KEGGicje:Cj1366c.
PATRICi20059697. VBICamJej33762_1347.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35478.1 .
PIRi C81281.
RefSeqi YP_002344754.1. NC_002163.1.

3D structure databases

ProteinModelPortali Q9PMT4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9PMT4. 29 interactions.
STRINGi 192222.Cj1366c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL35478 ; CAL35478 ; Cj1366c .
GeneIDi 905659.
KEGGi cje:Cj1366c.
PATRICi 20059697. VBICamJej33762_1347.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SAGICTL.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci CJEJ192222:GJTS-1339-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 11168.

Entry informationi

Entry nameiGLMS_CAMJE
AccessioniPrimary (citable) accession number: Q9PMT4
Secondary accession number(s): Q0P8P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3