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Q9PMT4

- GLMS_CAMJE

UniProt

Q9PMT4 - GLMS_CAMJE

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei593 – 5931For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciCJEJ192222:GJTS-1339-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:Cj1366c
    OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
    Taxonomic identifieri192222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000000799: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 598597Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135314Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    IntActiQ9PMT4. 29 interactions.
    STRINGi192222.Cj1366c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PMT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini277 – 421145SIS 1UniRule annotationAdd
    BLAST
    Domaini450 – 588139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiSAGICTL.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9PMT4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGYIGN NEKKQIILNG LKELEYRGYD SAGMAVMQEG ELSFFKAVGK    50
    LENLANKCTD FESQGYGFAI GHTRWATHGK PTEINAHPHL GQYSCVIHNG 100
    IIENYKEIKD KLEKEGVSFL SQTDTEVIVQ LFEFYARNLG VFEAWQKTIK 150
    ELRGAFATLL VTKKDPNHVY FAKNAAPLII GKNANKEWYF SSGDAPLIGS 200
    CDEVMYLEDL SLGYASKDEL VVYENDILKS LCFSKLSGDK AYAKKDGFRF 250
    FMEKEIYEQS RVMSEVLMGR IQGDEVVFDE LNNEDLSQVD EITLCACGTS 300
    YHAAMASAYL FERIAKVKAK VEIASEFRYR EAIIKKDSLF IVISQSGETA 350
    DTLEALKIAK EQGAKTFAIC NVDNSNIVRL AHLSLLTRAG IEKGVASTKA 400
    FATQVLTLWM LAIFMAQKRN LNVSAEIKAL LHTPNCVSVK QALHEKIHRL 450
    SKRYLDGHGF FFIGRDVFYP LALEGALKLK ELSYLHAEGY PAGEMKHGPI 500
    ALADSKLYTI ALMPKHMLYE KTKSNVEELI ARDSTVLSIS PLEFDLSDDF 550
    IKTNEQDHYM CEFFEMMVIT QLLAMEISIR LGNDVDMPRN LAKSVTVE 598
    Length:598
    Mass (Da):67,188
    Last modified:January 23, 2007 - v3
    Checksum:i9147183C44D594B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL35478.1.
    PIRiC81281.
    RefSeqiYP_002344754.1. NC_002163.1.

    Genome annotation databases

    EnsemblBacteriaiCAL35478; CAL35478; Cj1366c.
    GeneIDi905659.
    KEGGicje:Cj1366c.
    PATRICi20059697. VBICamJej33762_1347.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL111168 Genomic DNA. Translation: CAL35478.1 .
    PIRi C81281.
    RefSeqi YP_002344754.1. NC_002163.1.

    3D structure databases

    ProteinModelPortali Q9PMT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9PMT4. 29 interactions.
    STRINGi 192222.Cj1366c.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL35478 ; CAL35478 ; Cj1366c .
    GeneIDi 905659.
    KEGGi cje:Cj1366c.
    PATRICi 20059697. VBICamJej33762_1347.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi SAGICTL.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci CJEJ192222:GJTS-1339-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 11168.

    Entry informationi

    Entry nameiGLMS_CAMJE
    AccessioniPrimary (citable) accession number: Q9PMT4
    Secondary accession number(s): Q0P8P3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3