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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Binding sitei205ATPUniRule annotation1
Binding sitei296ATP; via carbonyl oxygenUniRule annotation1
Binding sitei327ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi353 – 356ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1320-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:Cj1402c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459211 – 400Phosphoglycerate kinaseAdd BLAST400

Proteomic databases

PaxDbiQ9PMQ5.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

IntActiQ9PMQ5. 70 interactors.
STRINGi192222.Cj1402c.

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi16 – 20Combined sources5
Helixi37 – 51Combined sources15
Beta strandi55 – 59Combined sources5
Helixi70 – 72Combined sources3
Helixi75 – 85Combined sources11
Beta strandi93 – 97Combined sources5
Helixi98 – 106Combined sources9
Beta strandi112 – 114Combined sources3
Helixi118 – 120Combined sources3
Helixi124 – 126Combined sources3
Helixi129 – 137Combined sources9
Beta strandi140 – 144Combined sources5
Helixi147 – 149Combined sources3
Turni155 – 158Combined sources4
Helixi159 – 163Combined sources5
Beta strandi168 – 171Combined sources4
Helixi173 – 185Combined sources13
Beta strandi191 – 197Combined sources7
Helixi202 – 212Combined sources11
Turni213 – 215Combined sources3
Beta strandi217 – 221Combined sources5
Helixi226 – 232Combined sources7
Helixi244 – 246Combined sources3
Helixi247 – 259Combined sources13
Beta strandi263 – 265Combined sources3
Beta strandi268 – 277Combined sources10
Beta strandi283 – 286Combined sources4
Helixi287 – 289Combined sources3
Beta strandi295 – 299Combined sources5
Helixi301 – 311Combined sources11
Beta strandi315 – 321Combined sources7
Helixi329 – 331Combined sources3
Helixi333 – 344Combined sources12
Beta strandi345 – 353Combined sources9
Helixi354 – 362Combined sources9
Helixi366 – 368Combined sources3
Beta strandi369 – 372Combined sources4
Helixi376 – 383Combined sources8
Helixi389 – 392Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q3VX-ray2.14A/B1-400[»]
ProteinModelPortaliQ9PMQ5.
SMRiQ9PMQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 24Substrate bindingUniRule annotation3
Regioni61 – 64Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiEVLMVEN.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PMQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIISIKDI DLAKKKVFIR CDFNVPQDDF LNITDDRRIR SAIPTIRYCL
60 70 80 90 100
DNGCSVILAS HLGRPKEISS KYSLEPVAKR LARLLDKEIV MAKDVIGEDA
110 120 130 140 150
KTKAMNLKAG EILLLENLRF EKGETKNDEN LAKELASMVQ VYINDAFGVC
160 170 180 190 200
HRAHSSVEAI TKFFDEKHKG AGFLLQKEID FASNLIKHPA RPFVAVVGGS
210 220 230 240 250
KVSGKLQALT NLLPKVDKLI IGGGMAFTFL KALGYDIGNS LLEEELLEEA
260 270 280 290 300
NKILTKGKNL GVKIYLPVDV VAAPACSQDV PMKFVPAQEI PNGWMGLDIG
310 320 330 340 350
PASVRLFKEV ISDAQTIWWN GPMGVFEIDK FSKGSIKMSH YISEGHATSV
360 370 380 390 400
VGGGDTADVV ARAGDADEMT FISTGGGASL ELIEGKELPG VKALRSKENE
Length:400
Mass (Da):43,591
Last modified:October 1, 2000 - v1
Checksum:i1DAB672AC4432BDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35511.1.
PIRiB81285.
RefSeqiWP_010891932.1. NC_002163.1.
YP_002344785.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35511; CAL35511; Cj1402c.
GeneIDi905691.
KEGGicje:Cj1402c.
PATRICi20059770. VBICamJej33762_1383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35511.1.
PIRiB81285.
RefSeqiWP_010891932.1. NC_002163.1.
YP_002344785.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q3VX-ray2.14A/B1-400[»]
ProteinModelPortaliQ9PMQ5.
SMRiQ9PMQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PMQ5. 70 interactors.
STRINGi192222.Cj1402c.

Proteomic databases

PaxDbiQ9PMQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL35511; CAL35511; Cj1402c.
GeneIDi905691.
KEGGicje:Cj1402c.
PATRICi20059770. VBICamJej33762_1383.

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227107.
KOiK00927.
OMAiEVLMVEN.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciCJEJ192222:GJTS-1320-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_CAMJE
AccessioniPrimary (citable) accession number: Q9PMQ5
Secondary accession number(s): Q0P8L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.