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Protein

Histidine biosynthesis bifunctional protein HisIE

Gene

hisI

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-AMP + diphosphate.
1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit hisF1 (hisF1), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1), Putative imidazole glycerol phosphate synthase subunit hisF2 (hisF2)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:G1G1F-1556-MONOMER
UniPathwayiUPA00031; UER00007
UPA00031; UER00008

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine biosynthesis bifunctional protein HisIE
Including the following 2 domains:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Phosphoribosyl-ATP pyrophosphatase (EC:3.6.1.31)
Short name:
PRA-PH
Gene namesi
Name:hisI
Synonyms:hisIE
Ordered Locus Names:Cj1604
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001364081 – 207Histidine biosynthesis bifunctional protein HisIEAdd BLAST207

Proteomic databases

PaxDbiQ9PM71
PRIDEiQ9PM71

Interactioni

Protein-protein interaction databases

IntActiQ9PM71, 7 interactors
STRINGi192222.Cj1604

Structurei

3D structure databases

ProteinModelPortaliQ9PM71
SMRiQ9PM71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 117Phosphoribosyl-AMP cyclohydrolaseAdd BLAST117
Regioni118 – 207Phosphoribosyl-ATP pyrophosphohydrolaseAdd BLAST90

Sequence similaritiesi

In the N-terminal section; belongs to the PRA-CH family.Curated
In the C-terminal section; belongs to the PRA-PH family.Curated

Phylogenomic databases

eggNOGiENOG4105K8F Bacteria
COG0139 LUCA
COG0140 LUCA
HOGENOMiHOG000277503
KOiK11755
OMAiVMACKDD

Family and domain databases

CDDicd11534 NTP-PPase_HisIE_like, 1 hit
Gene3Di3.10.20.400, 1 hit
HAMAPiMF_01020 HisE, 1 hit
MF_01019 HisIE, 1 hit
InterProiView protein in InterPro
IPR023019 His_synth_HisIE
IPR008179 HisE
IPR021130 PRib-ATP_PPHydrolase-like
IPR002496 PRib_AMP_CycHydrolase_dom
IPR038019 PRib_AMP_CycHydrolase_sf
PfamiView protein in Pfam
PF01502 PRA-CH, 1 hit
PF01503 PRA-PH, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002610 PRA_CycHdrlase, 1 hit
SUPFAMiSSF141734 SSF141734, 1 hit
TIGRFAMsiTIGR03188 histidine_hisI, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PM71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNFKELNEK IAWQKVDNLL PVIIQDAKTC EVLMLGFMNN EALEKSLESG
60 70 80 90 100
KVVFFSRTKQ RLWMKGEESG NFLNIIDLSL DCDNDTLLIL ANPVGPTCHT
110 120 130 140 150
GDISCFEKIS KNADFVFLAR LEKLINARKN ADENTSYTAK LFKSGTKRIA
160 170 180 190 200
QKVGEEGVET ALAATVKDKE ELICEAADLM YHLSVLLADA NLSFSDVISK

LKERHKA
Length:207
Mass (Da):23,176
Last modified:October 1, 2000 - v1
Checksum:iF5E4E6374D6E99C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA Translation: CAL35701.1
PIRiB81256
RefSeqiWP_002851143.1, NC_002163.1
YP_002344973.1, NC_002163.1

Genome annotation databases

EnsemblBacteriaiCAL35701; CAL35701; Cj1604
GeneIDi905159
KEGGicje:Cj1604
PATRICifig|192222.6.peg.1580

Entry informationi

Entry nameiHIS2_CAMJE
AccessioniPrimary (citable) accession number: Q9PM71
Secondary accession number(s): Q0P824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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