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Protein

Glutamate racemase

Gene

murI

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei70 – 701Proton donor/acceptorUniRule annotationBy similarity
Active sitei180 – 1801Proton donor/acceptorUniRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1615-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:Cj1652c
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Glutamate racemasePRO_0000095462Add
BLAST

Proteomic databases

PaxDbiQ9PM24.

Interactioni

Protein-protein interaction databases

IntActiQ9PM24. 18 interactions.
STRINGi192222.Cj1652c.

Structurei

Secondary structure

1
250
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 109Combined sources
Helixi13 – 219Combined sources
Beta strandi26 – 327Combined sources
Turni34 – 363Combined sources
Helixi44 – 5815Combined sources
Beta strandi64 – 685Combined sources
Helixi71 – 766Combined sources
Helixi78 – 847Combined sources
Beta strandi89 – 913Combined sources
Helixi93 – 10412Combined sources
Beta strandi111 – 1155Combined sources
Helixi117 – 1226Combined sources
Helixi124 – 1307Combined sources
Turni131 – 1333Combined sources
Beta strandi137 – 1415Combined sources
Helixi145 – 1506Combined sources
Helixi157 – 16711Combined sources
Beta strandi174 – 1785Combined sources
Beta strandi180 – 1823Combined sources
Helixi183 – 1864Combined sources
Helixi187 – 1948Combined sources
Beta strandi199 – 2024Combined sources
Helixi203 – 21412Combined sources
Beta strandi225 – 2328Combined sources
Helixi234 – 24411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UHFX-ray1.83A/B1-250[»]
3UHOX-ray2.20A/B1-250[»]
3UHPX-ray2.79A/B1-250[»]
ProteinModelPortaliQ9PM24.
SMRiQ9PM24. Positions 1-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Substrate bindingUniRule annotationCombined sources1 Publication
Regioni39 – 402Substrate bindingUniRule annotationCombined sources1 Publication
Regioni71 – 722Substrate bindingUniRule annotationCombined sources1 Publication
Regioni181 – 1822Substrate bindingUniRule annotationCombined sources1 Publication

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiLDFFKPH.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PM24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIGVFDSGV GGLSVLKSLY EARLFDEIIY YGDTARVPYG VKDKDTIIKF
60 70 80 90 100
CLEALDFFEQ FQIDMLIIAC NTASAYALDA LRAKAHFPVY GVIDAGVEAT
110 120 130 140 150
IKALHDKNKE ILVIATKATI KSEEYQKRLL SQGYTNINAL ATGLFVPMVE
160 170 180 190 200
EGIFEGDFLQ SAMEYYFKNI TTPDALILAC THFPLLGRSL SKYFGDKTKL
210 220 230 240 250
IHSGDAIVEF LKERENIDLK NHKAKLHFYA SSDVESLKNT AKIWLNLLRK
Length:250
Mass (Da):28,084
Last modified:October 1, 2000 - v1
Checksum:i6F0CE3981E24DE5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35749.1.
PIRiB81262.
RefSeqiWP_002851499.1. NC_002163.1.
YP_002345021.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35749; CAL35749; Cj1652c.
GeneIDi905925.
KEGGicje:Cj1652c.
PATRICi20060272. VBICamJej33762_1628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL111168 Genomic DNA. Translation: CAL35749.1.
PIRiB81262.
RefSeqiWP_002851499.1. NC_002163.1.
YP_002345021.1. NC_002163.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UHFX-ray1.83A/B1-250[»]
3UHOX-ray2.20A/B1-250[»]
3UHPX-ray2.79A/B1-250[»]
ProteinModelPortaliQ9PM24.
SMRiQ9PM24. Positions 1-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9PM24. 18 interactions.
STRINGi192222.Cj1652c.

Proteomic databases

PaxDbiQ9PM24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL35749; CAL35749; Cj1652c.
GeneIDi905925.
KEGGicje:Cj1652c.
PATRICi20060272. VBICamJej33762_1628.

Phylogenomic databases

eggNOGiENOG4105F03. Bacteria.
COG0796. LUCA.
HOGENOMiHOG000262396.
KOiK01776.
OMAiLDFFKPH.
OrthoDBiEOG6CZQQP.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciCJEJ192222:GJTS-1615-MONOMER.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700819 / NCTC 11168.
  2. "Crystal structure of glutamate racemase from Campylobacter jejuni subsp. jejuni."
    Center for structural genomics of infectious diseases (CSGID)
    Submitted (NOV-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) IN COMPLEX WITH SUBSTRATE.

Entry informationi

Entry nameiMURI_CAMJE
AccessioniPrimary (citable) accession number: Q9PM24
Secondary accession number(s): Q0P7X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.