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Q9PLU4

- HEM2_CHLMU

UniProt

Q9PLU4 - HEM2_CHLMU

Protein

Delta-aminolevulinic acid dehydratase

Gene

hemB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.By similarity

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei199 – 1991Schiff-base intermediate with substrateBy similarity
    Binding sitei209 – 2091Substrate 1By similarity
    Binding sitei221 – 2211Substrate 1By similarity
    Metal bindingi237 – 2371MagnesiumBy similarity
    Active sitei252 – 2521Schiff-base intermediate with substrateBy similarity
    Binding sitei278 – 2781Substrate 2By similarity
    Binding sitei317 – 3171Substrate 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-1-MONOMER.
    UniPathwayiUPA00251; UER00318.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydratase (EC:4.2.1.24)
    Short name:
    ALAD
    Short name:
    ALADH
    Alternative name(s):
    Porphobilinogen synthase
    Gene namesi
    Name:hemB
    Ordered Locus Names:TC_0001
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Delta-aminolevulinic acid dehydratasePRO_0000140495Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi243161.TC0001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PLU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.Curated

    Phylogenomic databases

    eggNOGiCOG0113.
    KOiK01698.
    OMAiEVLCKMA.
    OrthoDBiEOG6VXFCB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PLU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRLPLLKRP RRNRKSAAIR SMIRETNMVS SDLIWPIFLK EGSGIREEIP    50
    SMPGVYRWSL DTISRELERL CLIGLKAVIL FPVIEDQKKD QFGAYASHPY 100
    NIVCRGIQEI KKSFPQLCVI SDIALDPFTT SGHDGIFYNN EVLNDESVRV 150
    YGDIATLHAE MGADIVAPSD MMDGRVRHIR EKMDQMGFVN TGILSYSAKY 200
    ASYLYGPFRD ALSSHPQSGD KRQYQMDPAN VREALLECRL DEEEGADMVM 250
    IKPAGFYLDV IMKAQECTHL PVVAYQVSGE YSMIMAASLH GWLSKEGAIS 300
    ESLLAIKRAG ATAIISYATP WVLEWLARDA LPF 333
    Length:333
    Mass (Da):37,450
    Last modified:October 1, 2000 - v1
    Checksum:i905DC8BCE50B87B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF38895.1.
    PIRiB81751.
    RefSeqiNP_296385.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF38895; AAF38895; TC_0001.
    GeneIDi1245524.
    KEGGicmu:TC_0001.
    PATRICi20371336. VBIChlMur19118_0011.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF38895.1 .
    PIRi B81751.
    RefSeqi NP_296385.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PLU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF38895 ; AAF38895 ; TC_0001 .
    GeneIDi 1245524.
    KEGGi cmu:TC_0001.
    PATRICi 20371336. VBIChlMur19118_0011.

    Phylogenomic databases

    eggNOGi COG0113.
    KOi K01698.
    OMAi EVLCKMA.
    OrthoDBi EOG6VXFCB.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00318 .
    BioCyci CMUR243161:GHYU-1-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiHEM2_CHLMU
    AccessioniPrimary (citable) accession number: Q9PLU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3