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Q9PLU4 (HEM2_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta-aminolevulinic acid dehydratase

Short name=ALAD
Short name=ALADH
EC=4.2.1.24
Alternative name(s):
Porphobilinogen synthase
Gene names
Name:hemB
Ordered Locus Names:TC_0001
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen By similarity.

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the ALADH family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   LigandMagnesium
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

porphobilinogen synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Delta-aminolevulinic acid dehydratase
PRO_0000140495

Sites

Active site1991Schiff-base intermediate with substrate By similarity
Active site2521Schiff-base intermediate with substrate By similarity
Metal binding2371Magnesium By similarity
Binding site2091Substrate 1 By similarity
Binding site2211Substrate 1 By similarity
Binding site2781Substrate 2 By similarity
Binding site3171Substrate 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PLU4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 905DC8BCE50B87B5

FASTA33337,450
        10         20         30         40         50         60 
MTRLPLLKRP RRNRKSAAIR SMIRETNMVS SDLIWPIFLK EGSGIREEIP SMPGVYRWSL 

        70         80         90        100        110        120 
DTISRELERL CLIGLKAVIL FPVIEDQKKD QFGAYASHPY NIVCRGIQEI KKSFPQLCVI 

       130        140        150        160        170        180 
SDIALDPFTT SGHDGIFYNN EVLNDESVRV YGDIATLHAE MGADIVAPSD MMDGRVRHIR 

       190        200        210        220        230        240 
EKMDQMGFVN TGILSYSAKY ASYLYGPFRD ALSSHPQSGD KRQYQMDPAN VREALLECRL 

       250        260        270        280        290        300 
DEEEGADMVM IKPAGFYLDV IMKAQECTHL PVVAYQVSGE YSMIMAASLH GWLSKEGAIS 

       310        320        330 
ESLLAIKRAG ATAIISYATP WVLEWLARDA LPF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE002160 Genomic DNA. Translation: AAF38895.1.
PIRB81751.
RefSeqNP_296385.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PLU4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243161.TC0001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF38895; AAF38895; TC_0001.
GeneID1245524.
KEGGcmu:TC_0001.
PATRIC20371336. VBIChlMur19118_0011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0113.
KOK01698.
OMAEVLCKMA.
OrthoDBEOG6VXFCB.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-1-MONOMER.
UniPathwayUPA00251; UER00318.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERPTHR11458. PTHR11458. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM2_CHLMU
AccessionPrimary (citable) accession number: Q9PLU4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways