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Q9PLL6

- PCKG_CHLMU

UniProt

Q9PLL6 - PCKG_CHLMU

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761SubstrateUniRule annotation
Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
Metal bindingi225 – 2251ManganeseUniRule annotation
Binding sitei225 – 2251SubstrateUniRule annotation
Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
Binding sitei267 – 2671SubstrateUniRule annotation
Active sitei269 – 2691UniRule annotation
Metal bindingi292 – 2921ManganeseUniRule annotation
Binding sitei383 – 3831GTPUniRule annotation
Binding sitei414 – 4141GTPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi268 – 2736GTPUniRule annotation
Nucleotide bindingi507 – 5104GTPUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-90-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:TC_0083
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103597Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243161.TC0083.

Structurei

3D structure databases

ProteinModelPortaliQ9PLL6.
SMRiQ9PLL6. Positions 11-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni381 – 3833Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1274.
KOiK01596.
OMAiLENCYIC.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PLL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGDWMSKIT HSGLKSWIEE VIALVSPKDV RLCDGSEAEY QQLCQQMQEA
60 70 80 90 100
GVMTLLNPEL HPNCFLVRSS PDDVARVEQF TFICTKTKEE AGPTNNWRDP
110 120 130 140 150
QEMRAELHEL FQGCMQGRTL YIVPFCMGPL HSPFSLVGIE ITDSPYVVCS
160 170 180 190 200
MKIMTRMGAS VLEMLGSSGT FYKCLHSVGK PLAPGEKDVA WPCNPGHMRI
210 220 230 240 250
VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYLGHKQG WLAEHMLVIG
260 270 280 290 300
VTNPEGRKKY FAAAFPSACG KTNLAMLMPK LPGWKVECIG DDIAWIRPGD
310 320 330 340 350
DGRLYAVNPE FGFFGVAIGT SEKTNPNALA TCHSDSIFTN VALTSDGDVW
360 370 380 390 400
WEGKTATPPQ GMIDWKGRNW TPGGEPAAHP NARFTAPLDH CPSLDPQWDS
410 420 430 440 450
PQGVPLEAII FGGRRTETIP LVYESLSWEH GVMMGAGMSS TTTAAIAGEL
460 470 480 490 500
GKLRHDPFAM LPFCGYNMAA YFEHWLSFAG KGLQLPRIFS VNWFRKDENG
510 520 530 540 550
QFIWPGFSEN LRVLEWIFRR TDGEDSIARR TPIGYLPTEE GLNTTGLNLS
560 570 580 590
RDALQSLLAV DTQGWRAEVN NIREYCSIFG SDMPRQILEE LSRIENELK
Length:599
Mass (Da):66,438
Last modified:October 1, 2000 - v1
Checksum:i27E9983EF9227854
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF73531.1.
RefSeqiNP_296467.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF73531; AAF73531; TC_0083.
GeneIDi1245613.
KEGGicmu:TC_0083.
PATRICi20371518. VBIChlMur19118_0095.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF73531.1 .
RefSeqi NP_296467.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PLL6.
SMRi Q9PLL6. Positions 11-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0083.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF73531 ; AAF73531 ; TC_0083 .
GeneIDi 1245613.
KEGGi cmu:TC_0083.
PATRICi 20371518. VBIChlMur19118_0095.

Phylogenomic databases

eggNOGi COG1274.
KOi K01596.
OMAi LENCYIC.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci CMUR243161:GHYU-90-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiPCKG_CHLMU
AccessioniPrimary (citable) accession number: Q9PLL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3