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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76SubstrateUniRule annotation1
Metal bindingi225ManganeseUniRule annotation1
Metal bindingi245Manganese; via tele nitrogenUniRule annotation1
Binding sitei267SubstrateUniRule annotation1
Active sitei269UniRule annotation1
Metal bindingi292ManganeseUniRule annotation1
Binding sitei383GTPUniRule annotation1
Binding sitei414GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi268 – 273GTPUniRule annotation6
Nucleotide bindingi507 – 510GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:TC_0083
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001035971 – 599Phosphoenolpyruvate carboxykinase [GTP]Add BLAST599

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi243161.CmurN_010100000420

Structurei

3D structure databases

ProteinModelPortaliQ9PLL6
SMRiQ9PLL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni216 – 218Substrate bindingUniRule annotation3
Regioni381 – 383Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0M Bacteria
COG1274 LUCA
KOiK01596
OMAiCWLALTD

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PLL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGDWMSKIT HSGLKSWIEE VIALVSPKDV RLCDGSEAEY QQLCQQMQEA
60 70 80 90 100
GVMTLLNPEL HPNCFLVRSS PDDVARVEQF TFICTKTKEE AGPTNNWRDP
110 120 130 140 150
QEMRAELHEL FQGCMQGRTL YIVPFCMGPL HSPFSLVGIE ITDSPYVVCS
160 170 180 190 200
MKIMTRMGAS VLEMLGSSGT FYKCLHSVGK PLAPGEKDVA WPCNPGHMRI
210 220 230 240 250
VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYLGHKQG WLAEHMLVIG
260 270 280 290 300
VTNPEGRKKY FAAAFPSACG KTNLAMLMPK LPGWKVECIG DDIAWIRPGD
310 320 330 340 350
DGRLYAVNPE FGFFGVAIGT SEKTNPNALA TCHSDSIFTN VALTSDGDVW
360 370 380 390 400
WEGKTATPPQ GMIDWKGRNW TPGGEPAAHP NARFTAPLDH CPSLDPQWDS
410 420 430 440 450
PQGVPLEAII FGGRRTETIP LVYESLSWEH GVMMGAGMSS TTTAAIAGEL
460 470 480 490 500
GKLRHDPFAM LPFCGYNMAA YFEHWLSFAG KGLQLPRIFS VNWFRKDENG
510 520 530 540 550
QFIWPGFSEN LRVLEWIFRR TDGEDSIARR TPIGYLPTEE GLNTTGLNLS
560 570 580 590
RDALQSLLAV DTQGWRAEVN NIREYCSIFG SDMPRQILEE LSRIENELK
Length:599
Mass (Da):66,438
Last modified:October 1, 2000 - v1
Checksum:i27E9983EF9227854
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF73531.1
RefSeqiWP_010229325.1, NZ_ACOV01000001.1

Genome annotation databases

EnsemblBacteriaiAAF73531; AAF73531; TC_0083
GeneIDi1245613
KEGGicmu:TC_0083

Similar proteinsi

Entry informationi

Entry nameiPCKG_CHLMU
AccessioniPrimary (citable) accession number: Q9PLL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health