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Q9PLG1

- MUDD_CHLMU

UniProt

Q9PLG1 - MUDD_CHLMU

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Protein
Bifunctional enzyme MurC/Ddl
Gene
murC/ddl, TC_0143
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.UniRule annotation
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi731 – 7311Magnesium or manganese 1 By similarity
Metal bindingi744 – 7441Magnesium or manganese 1 By similarity
Metal bindingi744 – 7441Magnesium or manganese 2 By similarity
Metal bindingi746 – 7461Magnesium or manganese 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1167ATP Reviewed prediction
Nucleotide bindingi599 – 65456ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-153-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme MurC/Ddl
Including the following 2 domains:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:murC/ddl
Ordered Locus Names:TC_0143
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Bifunctional enzyme MurC/DdlUniRule annotation
PRO_0000177914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0143.

Structurei

3D structure databases

ProteinModelPortaliQ9PLG1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini566 – 777212ATP-grasp
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 445445UDP-N-acetylmuramate--alanine ligaseUniRule annotation
Add
BLAST
Regioni446 – 802357D-alanine--D-alanine ligaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the MurCDEF family.
In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.
Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG0773.
KOiK01921.
K01924.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PLG1-1 [UniParc]FASTAAdd to Basket

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MKSLCYHFIG IGGIGMSALA HILLDRGYSV SGSDLSEGKI VETLKNKGVK    50
FFLGNQEEHV PEESVVVYGS GISKNNPEFL AALNKGNRLI HRAELLAELT 100
KEQISIFVTG SHGKTTVSSL ITVILQEAGK TPSFAIGGLN GEGINGSSGS 150
EYFVAEADES DGSIRNYSPE FSVITNIDDE HLSNFGGDRE RLLASLQDFS 200
TKTRQICWYN GDCSRLRSCL VGHTFGFTSS CDLHILTYRQ EGWRSFFTVR 250
YQNVLYEDVE VRLVGEHNVM NAAAAMGVAL SLGIDEDTIR DALQRFPGVQ 300
RRLQRKNSSE VFLFLEDYAH HPSEIACTLQ AVRSAVGSRR VLAICQPHRF 350
SRLKECMGCF PSAFKGADEV LLTDVYSAGE AEEDVSYKEL AQSISRESLV 400
TCAYVPFSEL QGFLEKHIRV HDVCVALGAG DIEVLGESLR DFEPKKLSLG 450
LICGGRSCEH DISILSAQNI AKYLSHSFYE VQYFLITREG LWKTGSSLEL 500
SEETGKTIFD PEIAGKLSKV DVILPILHGP YGEDGAMQGF LETIGKPYTG 550
PSLVFAAIGM NKVLTKRFMS DLGIPVVPYL PLTLKGWKQD QEKCLAQIKA 600
AFSFPMFVKS VHLGSSIGVF EVHDTNELRD AINEAFVRDD DVFIEESRLG 650
CREIEVSFLG DGSGVFFVAG MHERRGRGGF IDYQEKYGLS GRASAQIVFD 700
VDLSKETREQ LLGVAEKIYR LLQGKGSCRI DFFVDNEGSF WLSEINPIPG 750
MTTASPFLAA FVRKGWNREQ IVHQLVIDGL QRFDQRQRLI STPLIDQALA 800
AR 802
Length:802
Mass (Da):88,744
Last modified:June 1, 2001 - v2
Checksum:i3FAF071C3CB78F96
GO

Sequence cautioni

The sequence AAF39021.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39021.1. Different initiation.
PIRiB81737.
RefSeqiNP_296522.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39021; AAF39021; TC_0143.
GeneIDi1245677.
KEGGicmu:TC_0143.
PATRICi20371652. VBIChlMur19118_0156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39021.1 . Different initiation.
PIRi B81737.
RefSeqi NP_296522.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PLG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39021 ; AAF39021 ; TC_0143 .
GeneIDi 1245677.
KEGGi cmu:TC_0143.
PATRICi 20371652. VBIChlMur19118_0156.

Phylogenomic databases

eggNOGi COG0773.
KOi K01921.
K01924.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CMUR243161:GHYU-153-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiMUDD_CHLMU
AccessioniPrimary (citable) accession number: Q9PLG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi