Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine.
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi731Magnesium or manganese 1By similarity1
Metal bindingi744Magnesium or manganese 1By similarity1
Metal bindingi744Magnesium or manganese 2By similarity1
Metal bindingi746Magnesium or manganese 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 116ATPSequence analysis7
Nucleotide bindingi599 – 654ATPBy similarityAdd BLAST56

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme MurC/Ddl
Including the following 2 domains:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:murC/ddl
Ordered Locus Names:TC_0143
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779141 – 802Bifunctional enzyme MurC/DdlAdd BLAST802

Proteomic databases

PRIDEiQ9PLG1

Interactioni

Protein-protein interaction databases

STRINGi243161.CmurN_010100000718

Structurei

3D structure databases

ProteinModelPortaliQ9PLG1
SMRiQ9PLG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini566 – 777ATP-graspAdd BLAST212

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 445UDP-N-acetylmuramate--alanine ligaseAdd BLAST445
Regioni446 – 802D-alanine--D-alanine ligaseAdd BLAST357

Sequence similaritiesi

In the N-terminal section; belongs to the MurCDEF family.Curated
In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated

Phylogenomic databases

eggNOGiENOG4105DFU Bacteria
COG0773 LUCA
COG1181 LUCA
KOiK01921
K01924

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
MF_00046 MurC, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
IPR016185 PreATP-grasp_dom_sf
IPR005758 UDP-N-AcMur_Ala_ligase_murC
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
SSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
TIGR01082 murC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PLG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLCYHFIG IGGIGMSALA HILLDRGYSV SGSDLSEGKI VETLKNKGVK
60 70 80 90 100
FFLGNQEEHV PEESVVVYGS GISKNNPEFL AALNKGNRLI HRAELLAELT
110 120 130 140 150
KEQISIFVTG SHGKTTVSSL ITVILQEAGK TPSFAIGGLN GEGINGSSGS
160 170 180 190 200
EYFVAEADES DGSIRNYSPE FSVITNIDDE HLSNFGGDRE RLLASLQDFS
210 220 230 240 250
TKTRQICWYN GDCSRLRSCL VGHTFGFTSS CDLHILTYRQ EGWRSFFTVR
260 270 280 290 300
YQNVLYEDVE VRLVGEHNVM NAAAAMGVAL SLGIDEDTIR DALQRFPGVQ
310 320 330 340 350
RRLQRKNSSE VFLFLEDYAH HPSEIACTLQ AVRSAVGSRR VLAICQPHRF
360 370 380 390 400
SRLKECMGCF PSAFKGADEV LLTDVYSAGE AEEDVSYKEL AQSISRESLV
410 420 430 440 450
TCAYVPFSEL QGFLEKHIRV HDVCVALGAG DIEVLGESLR DFEPKKLSLG
460 470 480 490 500
LICGGRSCEH DISILSAQNI AKYLSHSFYE VQYFLITREG LWKTGSSLEL
510 520 530 540 550
SEETGKTIFD PEIAGKLSKV DVILPILHGP YGEDGAMQGF LETIGKPYTG
560 570 580 590 600
PSLVFAAIGM NKVLTKRFMS DLGIPVVPYL PLTLKGWKQD QEKCLAQIKA
610 620 630 640 650
AFSFPMFVKS VHLGSSIGVF EVHDTNELRD AINEAFVRDD DVFIEESRLG
660 670 680 690 700
CREIEVSFLG DGSGVFFVAG MHERRGRGGF IDYQEKYGLS GRASAQIVFD
710 720 730 740 750
VDLSKETREQ LLGVAEKIYR LLQGKGSCRI DFFVDNEGSF WLSEINPIPG
760 770 780 790 800
MTTASPFLAA FVRKGWNREQ IVHQLVIDGL QRFDQRQRLI STPLIDQALA

AR
Length:802
Mass (Da):88,744
Last modified:June 1, 2001 - v2
Checksum:i3FAF071C3CB78F96
GO

Sequence cautioni

The sequence AAF39021 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF39021.1 Different initiation.
PIRiB81737
RefSeqiWP_010229511.1, NZ_ACOV01000003.1

Genome annotation databases

EnsemblBacteriaiAAF39021; AAF39021; TC_0143
GeneIDi1245677
KEGGicmu:TC_0143

Similar proteinsi

Entry informationi

Entry nameiMUDD_CHLMU
AccessioniPrimary (citable) accession number: Q9PLG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health