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Q9PLG1

- MUDD_CHLMU

UniProt

Q9PLG1 - MUDD_CHLMU

Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Cell wall formation.By similarity

    Catalytic activityi

    ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi731 – 7311Magnesium or manganese 1By similarity
    Metal bindingi744 – 7441Magnesium or manganese 1By similarity
    Metal bindingi744 – 7441Magnesium or manganese 2By similarity
    Metal bindingi746 – 7461Magnesium or manganese 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi110 – 1167ATPSequence Analysis
    Nucleotide bindingi599 – 65456ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-153-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional enzyme MurC/Ddl
    Including the following 2 domains:
    UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
    D-alanine--D-alanine ligase (EC:6.3.2.4)
    Alternative name(s):
    D-Ala-D-Ala ligase
    D-alanylalanine synthetase
    Gene namesi
    Name:murC/ddl
    Ordered Locus Names:TC_0143
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 802802Bifunctional enzyme MurC/DdlPRO_0000177914Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243161.TC0143.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PLG1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini566 – 777212ATP-graspAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 445445UDP-N-acetylmuramate--alanine ligaseAdd
    BLAST
    Regioni446 – 802357D-alanine--D-alanine ligaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the MurCDEF family.Curated
    In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated
    Contains 1 ATP-grasp domain.Curated

    Phylogenomic databases

    eggNOGiCOG0773.
    KOiK01921.
    K01924.
    OrthoDBiEOG64BQ73.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPiMF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view]
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9PLG1-1 [UniParc]FASTAAdd to Basket

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    MKSLCYHFIG IGGIGMSALA HILLDRGYSV SGSDLSEGKI VETLKNKGVK    50
    FFLGNQEEHV PEESVVVYGS GISKNNPEFL AALNKGNRLI HRAELLAELT 100
    KEQISIFVTG SHGKTTVSSL ITVILQEAGK TPSFAIGGLN GEGINGSSGS 150
    EYFVAEADES DGSIRNYSPE FSVITNIDDE HLSNFGGDRE RLLASLQDFS 200
    TKTRQICWYN GDCSRLRSCL VGHTFGFTSS CDLHILTYRQ EGWRSFFTVR 250
    YQNVLYEDVE VRLVGEHNVM NAAAAMGVAL SLGIDEDTIR DALQRFPGVQ 300
    RRLQRKNSSE VFLFLEDYAH HPSEIACTLQ AVRSAVGSRR VLAICQPHRF 350
    SRLKECMGCF PSAFKGADEV LLTDVYSAGE AEEDVSYKEL AQSISRESLV 400
    TCAYVPFSEL QGFLEKHIRV HDVCVALGAG DIEVLGESLR DFEPKKLSLG 450
    LICGGRSCEH DISILSAQNI AKYLSHSFYE VQYFLITREG LWKTGSSLEL 500
    SEETGKTIFD PEIAGKLSKV DVILPILHGP YGEDGAMQGF LETIGKPYTG 550
    PSLVFAAIGM NKVLTKRFMS DLGIPVVPYL PLTLKGWKQD QEKCLAQIKA 600
    AFSFPMFVKS VHLGSSIGVF EVHDTNELRD AINEAFVRDD DVFIEESRLG 650
    CREIEVSFLG DGSGVFFVAG MHERRGRGGF IDYQEKYGLS GRASAQIVFD 700
    VDLSKETREQ LLGVAEKIYR LLQGKGSCRI DFFVDNEGSF WLSEINPIPG 750
    MTTASPFLAA FVRKGWNREQ IVHQLVIDGL QRFDQRQRLI STPLIDQALA 800
    AR 802
    Length:802
    Mass (Da):88,744
    Last modified:June 1, 2001 - v2
    Checksum:i3FAF071C3CB78F96
    GO

    Sequence cautioni

    The sequence AAF39021.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39021.1. Different initiation.
    PIRiB81737.
    RefSeqiNP_296522.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39021; AAF39021; TC_0143.
    GeneIDi1245677.
    KEGGicmu:TC_0143.
    PATRICi20371652. VBIChlMur19118_0156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39021.1 . Different initiation.
    PIRi B81737.
    RefSeqi NP_296522.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PLG1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0143.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39021 ; AAF39021 ; TC_0143 .
    GeneIDi 1245677.
    KEGGi cmu:TC_0143.
    PATRICi 20371652. VBIChlMur19118_0156.

    Phylogenomic databases

    eggNOGi COG0773.
    KOi K01921.
    K01924.
    OrthoDBi EOG64BQ73.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci CMUR243161:GHYU-153-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.1190.10. 1 hit.
    3.40.50.20. 1 hit.
    3.40.50.720. 1 hit.
    3.90.190.20. 1 hit.
    HAMAPi MF_00046. MurC.
    MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR000291. D-Ala_lig_Van_CS.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR016040. NAD(P)-bd_dom.
    IPR016185. PreATP-grasp_dom.
    IPR005758. UDP-N-AcMur_Ala_ligase.
    [Graphical view ]
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 1 hit.
    PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    TIGR01082. murC. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00843. DALA_DALA_LIGASE_1. 1 hit.
    PS00844. DALA_DALA_LIGASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiMUDD_CHLMU
    AccessioniPrimary (citable) accession number: Q9PLG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3