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Q9PLG1

- MUDD_CHLMU

UniProt

Q9PLG1 - MUDD_CHLMU

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Protein

Bifunctional enzyme MurC/Ddl

Gene

murC/ddl

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.By similarity

Catalytic activityi

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi731 – 7311Magnesium or manganese 1By similarity
Metal bindingi744 – 7441Magnesium or manganese 1By similarity
Metal bindingi744 – 7441Magnesium or manganese 2By similarity
Metal bindingi746 – 7461Magnesium or manganese 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1167ATPSequence Analysis
Nucleotide bindingi599 – 65456ATPBy similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. UDP-N-acetylmuramate-L-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-153-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional enzyme MurC/Ddl
Including the following 2 domains:
UDP-N-acetylmuramate--L-alanine ligase (EC:6.3.2.8)
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:murC/ddl
Ordered Locus Names:TC_0143
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 802802Bifunctional enzyme MurC/DdlPRO_0000177914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0143.

Structurei

3D structure databases

ProteinModelPortaliQ9PLG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini566 – 777212ATP-graspAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 445445UDP-N-acetylmuramate--alanine ligaseAdd
BLAST
Regioni446 – 802357D-alanine--D-alanine ligaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the MurCDEF family.Curated
In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.Curated
Contains 1 ATP-grasp domain.Curated

Phylogenomic databases

eggNOGiCOG0773.
KOiK01921.
K01924.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PLG1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKSLCYHFIG IGGIGMSALA HILLDRGYSV SGSDLSEGKI VETLKNKGVK
60 70 80 90 100
FFLGNQEEHV PEESVVVYGS GISKNNPEFL AALNKGNRLI HRAELLAELT
110 120 130 140 150
KEQISIFVTG SHGKTTVSSL ITVILQEAGK TPSFAIGGLN GEGINGSSGS
160 170 180 190 200
EYFVAEADES DGSIRNYSPE FSVITNIDDE HLSNFGGDRE RLLASLQDFS
210 220 230 240 250
TKTRQICWYN GDCSRLRSCL VGHTFGFTSS CDLHILTYRQ EGWRSFFTVR
260 270 280 290 300
YQNVLYEDVE VRLVGEHNVM NAAAAMGVAL SLGIDEDTIR DALQRFPGVQ
310 320 330 340 350
RRLQRKNSSE VFLFLEDYAH HPSEIACTLQ AVRSAVGSRR VLAICQPHRF
360 370 380 390 400
SRLKECMGCF PSAFKGADEV LLTDVYSAGE AEEDVSYKEL AQSISRESLV
410 420 430 440 450
TCAYVPFSEL QGFLEKHIRV HDVCVALGAG DIEVLGESLR DFEPKKLSLG
460 470 480 490 500
LICGGRSCEH DISILSAQNI AKYLSHSFYE VQYFLITREG LWKTGSSLEL
510 520 530 540 550
SEETGKTIFD PEIAGKLSKV DVILPILHGP YGEDGAMQGF LETIGKPYTG
560 570 580 590 600
PSLVFAAIGM NKVLTKRFMS DLGIPVVPYL PLTLKGWKQD QEKCLAQIKA
610 620 630 640 650
AFSFPMFVKS VHLGSSIGVF EVHDTNELRD AINEAFVRDD DVFIEESRLG
660 670 680 690 700
CREIEVSFLG DGSGVFFVAG MHERRGRGGF IDYQEKYGLS GRASAQIVFD
710 720 730 740 750
VDLSKETREQ LLGVAEKIYR LLQGKGSCRI DFFVDNEGSF WLSEINPIPG
760 770 780 790 800
MTTASPFLAA FVRKGWNREQ IVHQLVIDGL QRFDQRQRLI STPLIDQALA

AR
Length:802
Mass (Da):88,744
Last modified:June 1, 2001 - v2
Checksum:i3FAF071C3CB78F96
GO

Sequence cautioni

The sequence AAF39021.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39021.1. Different initiation.
PIRiB81737.
RefSeqiNP_296522.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39021; AAF39021; TC_0143.
GeneIDi1245677.
KEGGicmu:TC_0143.
PATRICi20371652. VBIChlMur19118_0156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39021.1 . Different initiation.
PIRi B81737.
RefSeqi NP_296522.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PLG1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0143.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39021 ; AAF39021 ; TC_0143 .
GeneIDi 1245677.
KEGGi cmu:TC_0143.
PATRICi 20371652. VBIChlMur19118_0156.

Phylogenomic databases

eggNOGi COG0773.
KOi K01921.
K01924.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci CMUR243161:GHYU-153-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPi MF_00046. MurC.
MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view ]
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiMUDD_CHLMU
AccessioniPrimary (citable) accession number: Q9PLG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3