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Q9PLG1 (MUDD_CHLMU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional enzyme MurC/Ddl

Including the following 2 domains:

  1. UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
    Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase
  2. D-alanine--D-alanine ligase
    EC=6.3.2.4
    Alternative name(s):
    D-Ala-D-Ala ligase
    D-alanylalanine synthetase
Gene names
Name:murC/ddl
Ordered Locus Names:TC_0143
OrganismChlamydia muridarum (strain MoPn / Nigg) [Complete proteome] [HAMAP]
Taxonomic identifier243161 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia ›

Protein attributes

Sequence length802 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00046

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046

Subcellular location

Cytoplasm By similarity.

Sequence similarities

In the N-terminal section; belongs to the MurCDEF family.

In the C-terminal section; belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence caution

The sequence AAF39021.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 802802Bifunctional enzyme MurC/Ddl HAMAP-Rule MF_00046
PRO_0000177914

Regions

Domain566 – 777212ATP-grasp
Nucleotide binding110 – 1167ATP Potential
Nucleotide binding599 – 65456ATP By similarity
Region1 – 445445UDP-N-acetylmuramate--alanine ligase HAMAP-Rule MF_00046
Region446 – 802357D-alanine--D-alanine ligase HAMAP-Rule MF_00046

Sites

Metal binding7311Magnesium or manganese 1 By similarity
Metal binding7441Magnesium or manganese 1 By similarity
Metal binding7441Magnesium or manganese 2 By similarity
Metal binding7461Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9PLG1 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: 3FAF071C3CB78F96

FASTA80288,744
        10         20         30         40         50         60 
MKSLCYHFIG IGGIGMSALA HILLDRGYSV SGSDLSEGKI VETLKNKGVK FFLGNQEEHV 

        70         80         90        100        110        120 
PEESVVVYGS GISKNNPEFL AALNKGNRLI HRAELLAELT KEQISIFVTG SHGKTTVSSL 

       130        140        150        160        170        180 
ITVILQEAGK TPSFAIGGLN GEGINGSSGS EYFVAEADES DGSIRNYSPE FSVITNIDDE 

       190        200        210        220        230        240 
HLSNFGGDRE RLLASLQDFS TKTRQICWYN GDCSRLRSCL VGHTFGFTSS CDLHILTYRQ 

       250        260        270        280        290        300 
EGWRSFFTVR YQNVLYEDVE VRLVGEHNVM NAAAAMGVAL SLGIDEDTIR DALQRFPGVQ 

       310        320        330        340        350        360 
RRLQRKNSSE VFLFLEDYAH HPSEIACTLQ AVRSAVGSRR VLAICQPHRF SRLKECMGCF 

       370        380        390        400        410        420 
PSAFKGADEV LLTDVYSAGE AEEDVSYKEL AQSISRESLV TCAYVPFSEL QGFLEKHIRV 

       430        440        450        460        470        480 
HDVCVALGAG DIEVLGESLR DFEPKKLSLG LICGGRSCEH DISILSAQNI AKYLSHSFYE 

       490        500        510        520        530        540 
VQYFLITREG LWKTGSSLEL SEETGKTIFD PEIAGKLSKV DVILPILHGP YGEDGAMQGF 

       550        560        570        580        590        600 
LETIGKPYTG PSLVFAAIGM NKVLTKRFMS DLGIPVVPYL PLTLKGWKQD QEKCLAQIKA 

       610        620        630        640        650        660 
AFSFPMFVKS VHLGSSIGVF EVHDTNELRD AINEAFVRDD DVFIEESRLG CREIEVSFLG 

       670        680        690        700        710        720 
DGSGVFFVAG MHERRGRGGF IDYQEKYGLS GRASAQIVFD VDLSKETREQ LLGVAEKIYR 

       730        740        750        760        770        780 
LLQGKGSCRI DFFVDNEGSF WLSEINPIPG MTTASPFLAA FVRKGWNREQ IVHQLVIDGL 

       790        800 
QRFDQRQRLI STPLIDQALA AR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE002160 Genomic DNA. Translation: AAF39021.1. Different initiation.
PIRB81737.
RefSeqNP_296522.1. NC_002620.2.

3D structure databases

ProteinModelPortalQ9PLG1.
ModBaseSearch...

Protein-protein interaction databases

STRING243161.TC0143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF39021; AAF39021; TC_0143.
GeneID1245677.
KEGGcmu:TC0143.
PATRIC20371652. VBIChlMur19118_0156.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0773.
KOK01921.
K01924.
ProtClustDBPRK14573.

Enzyme and pathway databases

BioCycCMUR243161:GHYU-139-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.1190.10. 1 hit.
3.40.50.20. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPMF_00046. MurC. Fused.
MF_00047. Dala_Dala_lig. Fused.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR016185. PreATP-grasp_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
SSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR01082. murC. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUDD_CHLMU
AccessionPrimary (citable) accession number: Q9PLG1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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