Reviewed, UniProtKB/Swiss-Prot Q9PLF1 (IPYR_CHLMU)

Names and origin

Protein names

Recommended name:
    Inorganic pyrophosphatase
    EC=3.6.1.1
Alternative name(s):
    Pyrophosphate phospho-hydrolase
      Short name=PPase

Gene names

Name:	ppa
Ordered Locus Names:	TC_0153

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inorganic diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Inorganic pyrophosphatase HAMAP MF_00209		PRO_0000137490
Sites
	Metal binding	92	1	Magnesium 1 By similarity
	Metal binding	97	1	Magnesium 1 By similarity
	Metal binding	97	1	Magnesium 2 By similarity
	Metal binding	130	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9PLF1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5DEC1B71801AF81D	FASTA	209	23,310
	10 20 30 40 50 60 MSKTPLSIVH PWHGPVLTRD DYESLCCYIE ITPSDSVKFE LDKETGLLKV DRPQKFSNFC 70 80 90 100 110 120 PCLYGLLPKT YCGDLSGEYS GQQSNRDNIK GDGDPLDICV LTEKNITQGN ILLQARPIGG 130 140 150 160 170 180 IRILDSGEAD DKIIAVLEDD LVYGAMEDIS DCPGSVLDMI QHYFLTYKAT PESLIQAKPA 190 200 KIEIIGLYGK KEAQKVIRLA HEDYCNLFM

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF39030.1.
PIR	A81736.
RefSeq	NP_296532.1.
3D structure databases
HSSP	HSSP built from PDB template 1FAJ based on UniProtKB P17288.
ModBase	Search...
Genome annotation databases
GeneID	1245687.
GenomeReviews	Gene locus TC_0153 in contig AE002160_GR.
KEGG	cmu:TC0153.
TIGR	TC_0153.
Phylogenomic databases
HOGENOM	Q9PLF1.
OMA	NYESLCC.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0153-MON.
BRENDA	3.6.1.1. 256349.
Family and domain databases
HAMAP	MF_00209. [Tree]
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
Gene3D	G3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
PANTHER	PTHR10286. Pyrophosphatase. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
ProDom	PD002014. Inorg_pphsph. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IPYR_CHLMU

Accession

Primary (citable) accession number: Q9PLF1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)