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Q9PLA4

- GLMS_CHLMU

UniProt

Q9PLA4 - GLMS_CHLMU

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei601 – 6011For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-214-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:TC_0203
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 606605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135318Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243161.TC0203.

Structurei

3D structure databases

ProteinModelPortaliQ9PLA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini278 – 424147SIS 1UniRule annotationAdd
BLAST
Domaini455 – 596142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiRIIICAC.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9PLA4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIFGYLGQ RNAVPLVLEG LSKLEYRGYD SAGIAALTKD HLFVEKSVGP
60 70 80 90 100
VSQLCSKVSS DMHSQVAIGH TRWATHGEPS RFNAHPHVDM YESCALVHNG
110 120 130 140 150
IIENFQTLRE DLSSKGVEFS SDTDTEVIVQ LFASRYRETG DLVQSFSWTL
160 170 180 190 200
KQLQGSFACA LVHQDHPEIL LCATYESPLI LGLGEEEVFI SSDVHAFLKY
210 220 230 240 250
SCQIQTLASG ELAVLRIGRP VEIYNFELSR IQKEVRCIDH AEGSLDKQGF
260 270 280 290 300
DYYMLKEIYE QPEVFERILH FVCEENGFAE SFLKEFSFEG IESLHIVACG
310 320 330 340 350
SSYHAGCLAK YVIESMVSIP VYVETASEFR YRQPYIAKRS LAILISQSGE
360 370 380 390 400
TADTLAALNE FRKLDEVRVL GICNVRGSVL ASRVDHCVFI EAGLEVGVAS
410 420 430 440 450
TKAFTAQLLV LILLGLKLAS QRQEISKQDL MQAVQGLREL PRLTRLFLDS
460 470 480 490 500
SIHDWRCRQS KETSFIFLGR RFMYPICMEA ALKLKEIAYV EANAYPAGEM
510 520 530 540 550
KHGPIALIQE GTPVIVYCGD PFVYTKTIGA IMEVKARKAY VIALARESNQ
560 570 580 590 600
DIAAVSDEQI YIPDSHDLAA PILFAIAGQI MAYTMALQKG TEVDRPRNLA

KSVTVE
Length:606
Mass (Da):67,569
Last modified:January 23, 2007 - v3
Checksum:i2B6469726717C2AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39075.1.
PIRiB81729.
RefSeqiNP_296582.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39075; AAF39075; TC_0203.
GeneIDi1246329.
KEGGicmu:TC_0203.
PATRICi20371786. VBIChlMur19118_0222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39075.1 .
PIRi B81729.
RefSeqi NP_296582.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PLA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0203.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39075 ; AAF39075 ; TC_0203 .
GeneIDi 1246329.
KEGGi cmu:TC_0203.
PATRICi 20371786. VBIChlMur19118_0222.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi RIIICAC.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-214-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiGLMS_CHLMU
AccessioniPrimary (citable) accession number: Q9PLA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3