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Q9PLA4

- GLMS_CHLMU

UniProt

Q9PLA4 - GLMS_CHLMU

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei601 – 6011For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-214-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:TC_0203
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 606605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135318Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243161.TC0203.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PLA4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 218217Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini278 – 424147SIS 1UniRule annotationAdd
    BLAST
    Domaini455 – 596142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiRIIICAC.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9PLA4-1 [UniParc]FASTAAdd to Basket

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    MCGIFGYLGQ RNAVPLVLEG LSKLEYRGYD SAGIAALTKD HLFVEKSVGP    50
    VSQLCSKVSS DMHSQVAIGH TRWATHGEPS RFNAHPHVDM YESCALVHNG 100
    IIENFQTLRE DLSSKGVEFS SDTDTEVIVQ LFASRYRETG DLVQSFSWTL 150
    KQLQGSFACA LVHQDHPEIL LCATYESPLI LGLGEEEVFI SSDVHAFLKY 200
    SCQIQTLASG ELAVLRIGRP VEIYNFELSR IQKEVRCIDH AEGSLDKQGF 250
    DYYMLKEIYE QPEVFERILH FVCEENGFAE SFLKEFSFEG IESLHIVACG 300
    SSYHAGCLAK YVIESMVSIP VYVETASEFR YRQPYIAKRS LAILISQSGE 350
    TADTLAALNE FRKLDEVRVL GICNVRGSVL ASRVDHCVFI EAGLEVGVAS 400
    TKAFTAQLLV LILLGLKLAS QRQEISKQDL MQAVQGLREL PRLTRLFLDS 450
    SIHDWRCRQS KETSFIFLGR RFMYPICMEA ALKLKEIAYV EANAYPAGEM 500
    KHGPIALIQE GTPVIVYCGD PFVYTKTIGA IMEVKARKAY VIALARESNQ 550
    DIAAVSDEQI YIPDSHDLAA PILFAIAGQI MAYTMALQKG TEVDRPRNLA 600
    KSVTVE 606
    Length:606
    Mass (Da):67,569
    Last modified:January 23, 2007 - v3
    Checksum:i2B6469726717C2AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39075.1.
    PIRiB81729.
    RefSeqiNP_296582.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39075; AAF39075; TC_0203.
    GeneIDi1246329.
    KEGGicmu:TC_0203.
    PATRICi20371786. VBIChlMur19118_0222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39075.1 .
    PIRi B81729.
    RefSeqi NP_296582.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PLA4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0203.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39075 ; AAF39075 ; TC_0203 .
    GeneIDi 1246329.
    KEGGi cmu:TC_0203.
    PATRICi 20371786. VBIChlMur19118_0222.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi RIIICAC.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci CMUR243161:GHYU-214-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiGLMS_CHLMU
    AccessioniPrimary (citable) accession number: Q9PLA4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3