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Q9PL93

- RIR1_CHLMU

UniProt

Q9PL93 - RIR1_CHLMU

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Protein
Ribonucleoside-diphosphate reductase subunit alpha
Gene
nrdA, TC_0214
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Enzyme regulationi

Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei442 – 4421Substrate By similarity
Sitei458 – 4581Important for hydrogen atom transfer By similarity
Sitei465 – 4651Allosteric effector binding By similarity
Binding sitei486 – 4861Substrate; via amide nitrogen By similarity
Sitei495 – 4951Allosteric effector binding By similarity
Active sitei670 – 6701Proton acceptor By similarity
Active sitei672 – 6721Cysteine radical intermediate By similarity
Active sitei674 – 6741Proton acceptor By similarity
Sitei687 – 6871Important for hydrogen atom transfer By similarity
Sitei990 – 9901Important for electron transfer By similarity
Sitei991 – 9911Important for electron transfer By similarity
Sitei1043 – 10431Interacts with thioredoxin/glutaredoxin By similarity
Sitei1046 – 10461Interacts with thioredoxin/glutaredoxin By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-225-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit alpha (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase
Gene namesi
Name:nrdA
Ordered Locus Names:TC_0214
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10471047Ribonucleoside-diphosphate reductase subunit alpha
PRO_0000187210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi458 ↔ 687Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi243161.TC0214.

Structurei

3D structure databases

ProteinModelPortaliQ9PL93.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 111103ATP-cone 1
Add
BLAST
Domaini118 – 219102ATP-cone 2
Add
BLAST
Domaini237 – 32791ATP-cone 3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 4582Substrate binding By similarity
Regioni670 – 6745Substrate binding By similarity
Regioni857 – 8615Substrate binding By similarity

Sequence similaritiesi

Contains 3 ATP-cone domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0209.
KOiK00525.
OMAiANGSIQH.
OrthoDBiEOG6J48HC.

Family and domain databases

InterProiIPR005144. ATP-cone.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF03477. ATP-cone. 2 hits.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS51161. ATP_CONE. 3 hits.
PS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PL93-1 [UniParc]FASTAAdd to Basket

« Hide

MVDLQEKQCT IVKRNGMFVP FDRNRIFQAL EAAFRDTRRI DDHMPLPEDL     50
ENSIRSITHQ VVKEVVQKIT DGQVVTVERI QDMVESQLYI NGLQDVARDY 100
VVYRDDRKAH REKSWQSLSV IRRCGTTVHF NPMKISAALE KAFRATDRIE 150
GMTPDFVREE VNALTQKIVA EIEERCSQQD SRIDIEQIQD IVEQQLMVVG 200
HYATAKNYIL YREARARVRD NRVEDQIVEE APSEETFEVL SKDGSTYMIT 250
HSQLLARLAR ACSRFPETTD AALLTDMAFS NFYSGIKESE VVLACIMAAR 300
ANIEKEPDYA FVAAELLLDV VYKEALDRSR GDEDLEQVYR DHFKRYIMEG 350
DSYRLNPELK NLFDLDALAN AMDLSRDLQF SYMGIQNLYD RYFNHDDGRR 400
LETPQIFWMR VAMGLALKEQ DKTYWAITFY NLLSTFRYTP ATPTLFNSGM 450
RHSQLSSCYL STVQDDLVNI YKVISDNAML SKWAGGIGND WTAIRATGAL 500
IKGTNGKSQG VIPFIKVTND TAVAVNQGGK RKGAVCVYLE VWHLDYEDFL 550
ELRKNTGDDR RRAHDVNTAS WIPDLFFKRL QQKGSWTLFS PDDVPGLHDA 600
YGEEFERLYE EYERKVDSGE IRLYKKVEAE DLWRKMLSML FETGHPWMTF 650
KDPSNIRSAQ DHTGVVRCSN LCTEILLNCS ETETAVCNLG SVNLVQHILD 700
DGLDEEKLSE TISIAVRMLD NVIDINFYPT KEAKEANFAH RAIGLGVMGF 750
QDALYKLDIS YASQEAVEFA DYSSELISYY AIQASCLLAK ERGTYSSYKG 800
SKWDRGLLPI DTIQLLANYR GKDNLQMDTS VRKDWEPIRS LIREHGMRNC 850
QLMAIAPTAT ISNIIGVTQS IEPTYKHLFV KSNLSGEFTI PNVYLIEKLK 900
KLGIWDADML DDLKYFDGSL LEIERVPDHI KHIFLTAFEI EPEWILECAS 950
RRQKWIDMGQ SLNLYLAQPD GKKLSNMYLT AWKKGLKTTY YLRSSSATTV 1000
EKSFVDINKR GIQPRWMKNK SASAGIVVER ASKTPVCSLE EGCEVCQ 1047
Length:1,047
Mass (Da):120,036
Last modified:October 1, 2000 - v1
Checksum:i9B3FFD9BFAF817AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39086.1.
PIRiF81728.
RefSeqiNP_296593.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39086; AAF39086; TC_0214.
GeneIDi1246340.
KEGGicmu:TC_0214.
PATRICi20371810. VBIChlMur19118_0234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39086.1 .
PIRi F81728.
RefSeqi NP_296593.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PL93.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243161.TC0214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39086 ; AAF39086 ; TC_0214 .
GeneIDi 1246340.
KEGGi cmu:TC_0214.
PATRICi 20371810. VBIChlMur19118_0234.

Phylogenomic databases

eggNOGi COG0209.
KOi K00525.
OMAi ANGSIQH.
OrthoDBi EOG6J48HC.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci CMUR243161:GHYU-225-MONOMER.

Family and domain databases

InterProi IPR005144. ATP-cone.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view ]
Pfami PF03477. ATP-cone. 2 hits.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
SUPFAMi SSF48168. SSF48168. 1 hit.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
PROSITEi PS51161. ATP_CONE. 3 hits.
PS00089. RIBORED_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiRIR1_CHLMU
AccessioniPrimary (citable) accession number: Q9PL93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi