Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9PL93

- RIR1_CHLMU

UniProt

Q9PL93 - RIR1_CHLMU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ribonucleoside-diphosphate reductase subunit alpha

Gene

nrdA

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Enzyme regulationi

Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei442 – 4421SubstrateBy similarity
Sitei458 – 4581Important for hydrogen atom transferBy similarity
Sitei465 – 4651Allosteric effector bindingBy similarity
Binding sitei486 – 4861Substrate; via amide nitrogenBy similarity
Sitei495 – 4951Allosteric effector bindingBy similarity
Active sitei670 – 6701Proton acceptorBy similarity
Active sitei672 – 6721Cysteine radical intermediateBy similarity
Active sitei674 – 6741Proton acceptorBy similarity
Sitei687 – 6871Important for hydrogen atom transferBy similarity
Sitei990 – 9901Important for electron transferBy similarity
Sitei991 – 9911Important for electron transferBy similarity
Sitei1043 – 10431Interacts with thioredoxin/glutaredoxinBy similarity
Sitei1046 – 10461Interacts with thioredoxin/glutaredoxinBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-225-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit alpha (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase
Gene namesi
Name:nrdA
Ordered Locus Names:TC_0214
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10471047Ribonucleoside-diphosphate reductase subunit alphaPRO_0000187210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi458 ↔ 687Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi243161.TC0214.

Structurei

3D structure databases

ProteinModelPortaliQ9PL93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 111103ATP-cone 1PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 219102ATP-cone 2PROSITE-ProRule annotationAdd
BLAST
Domaini237 – 32791ATP-cone 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni457 – 4582Substrate bindingBy similarity
Regioni670 – 6745Substrate bindingBy similarity
Regioni857 – 8615Substrate bindingBy similarity

Sequence similaritiesi

Contains 3 ATP-cone domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0209.
KOiK00525.
OMAiANGSIQH.
OrthoDBiEOG6J48HC.

Family and domain databases

InterProiIPR005144. ATP-cone.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF03477. ATP-cone. 2 hits.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
PROSITEiPS51161. ATP_CONE. 3 hits.
PS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PL93-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDLQEKQCT IVKRNGMFVP FDRNRIFQAL EAAFRDTRRI DDHMPLPEDL
60 70 80 90 100
ENSIRSITHQ VVKEVVQKIT DGQVVTVERI QDMVESQLYI NGLQDVARDY
110 120 130 140 150
VVYRDDRKAH REKSWQSLSV IRRCGTTVHF NPMKISAALE KAFRATDRIE
160 170 180 190 200
GMTPDFVREE VNALTQKIVA EIEERCSQQD SRIDIEQIQD IVEQQLMVVG
210 220 230 240 250
HYATAKNYIL YREARARVRD NRVEDQIVEE APSEETFEVL SKDGSTYMIT
260 270 280 290 300
HSQLLARLAR ACSRFPETTD AALLTDMAFS NFYSGIKESE VVLACIMAAR
310 320 330 340 350
ANIEKEPDYA FVAAELLLDV VYKEALDRSR GDEDLEQVYR DHFKRYIMEG
360 370 380 390 400
DSYRLNPELK NLFDLDALAN AMDLSRDLQF SYMGIQNLYD RYFNHDDGRR
410 420 430 440 450
LETPQIFWMR VAMGLALKEQ DKTYWAITFY NLLSTFRYTP ATPTLFNSGM
460 470 480 490 500
RHSQLSSCYL STVQDDLVNI YKVISDNAML SKWAGGIGND WTAIRATGAL
510 520 530 540 550
IKGTNGKSQG VIPFIKVTND TAVAVNQGGK RKGAVCVYLE VWHLDYEDFL
560 570 580 590 600
ELRKNTGDDR RRAHDVNTAS WIPDLFFKRL QQKGSWTLFS PDDVPGLHDA
610 620 630 640 650
YGEEFERLYE EYERKVDSGE IRLYKKVEAE DLWRKMLSML FETGHPWMTF
660 670 680 690 700
KDPSNIRSAQ DHTGVVRCSN LCTEILLNCS ETETAVCNLG SVNLVQHILD
710 720 730 740 750
DGLDEEKLSE TISIAVRMLD NVIDINFYPT KEAKEANFAH RAIGLGVMGF
760 770 780 790 800
QDALYKLDIS YASQEAVEFA DYSSELISYY AIQASCLLAK ERGTYSSYKG
810 820 830 840 850
SKWDRGLLPI DTIQLLANYR GKDNLQMDTS VRKDWEPIRS LIREHGMRNC
860 870 880 890 900
QLMAIAPTAT ISNIIGVTQS IEPTYKHLFV KSNLSGEFTI PNVYLIEKLK
910 920 930 940 950
KLGIWDADML DDLKYFDGSL LEIERVPDHI KHIFLTAFEI EPEWILECAS
960 970 980 990 1000
RRQKWIDMGQ SLNLYLAQPD GKKLSNMYLT AWKKGLKTTY YLRSSSATTV
1010 1020 1030 1040
EKSFVDINKR GIQPRWMKNK SASAGIVVER ASKTPVCSLE EGCEVCQ
Length:1,047
Mass (Da):120,036
Last modified:October 1, 2000 - v1
Checksum:i9B3FFD9BFAF817AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39086.1.
PIRiF81728.
RefSeqiNP_296593.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39086; AAF39086; TC_0214.
GeneIDi1246340.
KEGGicmu:TC_0214.
PATRICi20371810. VBIChlMur19118_0234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39086.1 .
PIRi F81728.
RefSeqi NP_296593.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PL93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39086 ; AAF39086 ; TC_0214 .
GeneIDi 1246340.
KEGGi cmu:TC_0214.
PATRICi 20371810. VBIChlMur19118_0234.

Phylogenomic databases

eggNOGi COG0209.
KOi K00525.
OMAi ANGSIQH.
OrthoDBi EOG6J48HC.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci CMUR243161:GHYU-225-MONOMER.

Family and domain databases

InterProi IPR005144. ATP-cone.
IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view ]
Pfami PF03477. ATP-cone. 2 hits.
PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
SUPFAMi SSF48168. SSF48168. 1 hit.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
PROSITEi PS51161. ATP_CONE. 3 hits.
PS00089. RIBORED_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiRIR1_CHLMU
AccessioniPrimary (citable) accession number: Q9PL93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3