Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1By similarity
Metal bindingi120 – 1201Iron 1By similarity
Metal bindingi120 – 1201Iron 2By similarity
Metal bindingi123 – 1231Iron 1By similarity
Active sitei129 – 1291By similarity
Metal bindingi193 – 1931Iron 2By similarity
Metal bindingi227 – 2271Iron 2By similarity
Metal bindingi230 – 2301Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-226-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:TC_0215
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190473Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi243161.TC0215.

Structurei

3D structure databases

ProteinModelPortaliQ9PL92.
SMRiQ9PL92. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiCNRRCQQ.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PL92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN
60 70 80 90 100
WLPTEISMGK DIELWKSNVL SEDERRVILL NLGFFSTAES LVGNNIVLAI
110 120 130 140 150
FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAS
160 170 180 190 200
IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FIKNLVGYYI IMEGIFFYSG
210 220 230 240 250
FVMILSFHRQ NKMVGIGEQY QYILRDETIH LNFGVDLING IKEENPEIWT
260 270 280 290 300
TELQQEIIEM IQRAVDLEID YARDCLPRGI LGLRASMFID YVQHIADRRL
310 320 330 340
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVTEYQH AASLTW
Length:346
Mass (Da):40,488
Last modified:September 30, 2000 - v1
Checksum:iC5AF2C3372FBDA57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF39087.1.
PIRiG81728.
RefSeqiNP_296594.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39087; AAF39087; TC_0215.
KEGGicmu:TC_0215.
PATRICi20371812. VBIChlMur19118_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF39087.1.
PIRiG81728.
RefSeqiNP_296594.1. NC_002620.2.

3D structure databases

ProteinModelPortaliQ9PL92.
SMRiQ9PL92. Positions 2-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243161.TC0215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF39087; AAF39087; TC_0215.
KEGGicmu:TC_0215.
PATRICi20371812. VBIChlMur19118_0235.

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiCNRRCQQ.
OrthoDBiEOG6J48J7.

Enzyme and pathway databases

UniPathwayiUPA00326.
BioCyciCMUR243161:GHYU-226-MONOMER.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiRIR2_CHLMU
AccessioniPrimary (citable) accession number: Q9PL92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2001
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.