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Q9PL92

- RIR2_CHLMU

UniProt

Q9PL92 - RIR2_CHLMU

Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi89 – 891Iron 1By similarity
    Metal bindingi120 – 1201Iron 1By similarity
    Metal bindingi120 – 1201Iron 2By similarity
    Metal bindingi123 – 1231Iron 1By similarity
    Active sitei129 – 1291By similarity
    Metal bindingi193 – 1931Iron 2By similarity
    Metal bindingi227 – 2271Iron 2By similarity
    Metal bindingi230 – 2301Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. deoxyribonucleotide biosynthetic process Source: InterPro
    3. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciCMUR243161:GHYU-226-MONOMER.
    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:nrdB
    Ordered Locus Names:TC_0215
    OrganismiChlamydia muridarum (strain MoPn / Nigg)
    Taxonomic identifieri243161 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000800: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ribonucleoside-diphosphate reductase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190473Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.By similarity

    Protein-protein interaction databases

    STRINGi243161.TC0215.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9PL92.
    SMRiQ9PL92. Positions 2-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    KOiK00526.
    OMAiHSETYAK.
    OrthoDBiEOG6J48J7.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000355. NrdB. 1 hit.
    SUPFAMiSSF47240. SSF47240. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9PL92-1 [UniParc]FASTAAdd to Basket

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    MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN    50
    WLPTEISMGK DIELWKSNVL SEDERRVILL NLGFFSTAES LVGNNIVLAI 100
    FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAS 150
    IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FIKNLVGYYI IMEGIFFYSG 200
    FVMILSFHRQ NKMVGIGEQY QYILRDETIH LNFGVDLING IKEENPEIWT 250
    TELQQEIIEM IQRAVDLEID YARDCLPRGI LGLRASMFID YVQHIADRRL 300
    ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVTEYQH AASLTW 346
    Length:346
    Mass (Da):40,488
    Last modified:October 1, 2000 - v1
    Checksum:iC5AF2C3372FBDA57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39087.1.
    PIRiG81728.
    RefSeqiNP_296594.1. NC_002620.2.

    Genome annotation databases

    EnsemblBacteriaiAAF39087; AAF39087; TC_0215.
    GeneIDi1246341.
    KEGGicmu:TC_0215.
    PATRICi20371812. VBIChlMur19118_0235.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE002160 Genomic DNA. Translation: AAF39087.1 .
    PIRi G81728.
    RefSeqi NP_296594.1. NC_002620.2.

    3D structure databases

    ProteinModelPortali Q9PL92.
    SMRi Q9PL92. Positions 2-318.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243161.TC0215.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF39087 ; AAF39087 ; TC_0215 .
    GeneIDi 1246341.
    KEGGi cmu:TC_0215.
    PATRICi 20371812. VBIChlMur19118_0235.

    Phylogenomic databases

    eggNOGi COG0208.
    KOi K00526.
    OMAi HSETYAK.
    OrthoDBi EOG6J48J7.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .
    BioCyci CMUR243161:GHYU-226-MONOMER.

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR026023. RNR_bsu_prok.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000355. NrdB. 1 hit.
    SUPFAMi SSF47240. SSF47240. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MoPn / Nigg.

    Entry informationi

    Entry nameiRIR2_CHLMU
    AccessioniPrimary (citable) accession number: Q9PL92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3