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Q9PL92

- RIR2_CHLMU

UniProt

Q9PL92 - RIR2_CHLMU

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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene
nrdB, TC_0215
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi89 – 891Iron 1 By similarity
Metal bindingi120 – 1201Iron 1 By similarity
Metal bindingi120 – 1201Iron 2 By similarity
Metal bindingi123 – 1231Iron 1 By similarity
Active sitei129 – 1291 By similarity
Metal bindingi193 – 1931Iron 2 By similarity
Metal bindingi227 – 2271Iron 2 By similarity
Metal bindingi230 – 2301Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. deoxyribonucleotide biosynthetic process Source: InterPro
  3. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-226-MONOMER.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:TC_0215
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Ribonucleoside-diphosphate reductase subunit betaPRO_0000190473Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits By similarity.

Protein-protein interaction databases

STRINGi243161.TC0215.

Structurei

3D structure databases

ProteinModelPortaliQ9PL92.
SMRiQ9PL92. Positions 2-318.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
KOiK00526.
OMAiHSETYAK.
OrthoDBiEOG6J48J7.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PL92-1 [UniParc]FASTAAdd to Basket

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MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN    50
WLPTEISMGK DIELWKSNVL SEDERRVILL NLGFFSTAES LVGNNIVLAI 100
FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAS 150
IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FIKNLVGYYI IMEGIFFYSG 200
FVMILSFHRQ NKMVGIGEQY QYILRDETIH LNFGVDLING IKEENPEIWT 250
TELQQEIIEM IQRAVDLEID YARDCLPRGI LGLRASMFID YVQHIADRRL 300
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVTEYQH AASLTW 346
Length:346
Mass (Da):40,488
Last modified:October 1, 2000 - v1
Checksum:iC5AF2C3372FBDA57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39087.1.
PIRiG81728.
RefSeqiNP_296594.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39087; AAF39087; TC_0215.
GeneIDi1246341.
KEGGicmu:TC_0215.
PATRICi20371812. VBIChlMur19118_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39087.1 .
PIRi G81728.
RefSeqi NP_296594.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PL92.
SMRi Q9PL92. Positions 2-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39087 ; AAF39087 ; TC_0215 .
GeneIDi 1246341.
KEGGi cmu:TC_0215.
PATRICi 20371812. VBIChlMur19118_0235.

Phylogenomic databases

eggNOGi COG0208.
KOi K00526.
OMAi HSETYAK.
OrthoDBi EOG6J48J7.

Enzyme and pathway databases

UniPathwayi UPA00326 .
BioCyci CMUR243161:GHYU-226-MONOMER.

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
PIRSFi PIRSF000355. NrdB. 1 hit.
SUPFAMi SSF47240. SSF47240. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiRIR2_CHLMU
AccessioniPrimary (citable) accession number: Q9PL92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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