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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89Iron 1By similarity1
Metal bindingi120Iron 1By similarity1
Metal bindingi120Iron 2By similarity1
Metal bindingi123Iron 1By similarity1
Active sitei129By similarity1
Metal bindingi193Iron 2By similarity1
Metal bindingi227Iron 2By similarity1
Metal bindingi230Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit beta (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:nrdB
Ordered Locus Names:TC_0215
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904731 – 346Ribonucleoside-diphosphate reductase subunit betaAdd BLAST346

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi243161.CmurN_010100001073.

Structurei

3D structure databases

ProteinModelPortaliQ9PL92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E05. Bacteria.
COG0208. LUCA.
KOiK00526.
OMAiCNRRCQQ.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9PL92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQADILDGKQ KRVNLNSKRL VNCNQVDVNQ LVPIKYKWAW EHYLNGCANN
60 70 80 90 100
WLPTEISMGK DIELWKSNVL SEDERRVILL NLGFFSTAES LVGNNIVLAI
110 120 130 140 150
FKHVTNPEAR QYLLRQAFEE AVHTHTFLYI CESLGLDEKE IFNAYNERAS
160 170 180 190 200
IKAKDDFQME ITGKVLDPNF RTDSVEGLQE FIKNLVGYYI IMEGIFFYSG
210 220 230 240 250
FVMILSFHRQ NKMVGIGEQY QYILRDETIH LNFGVDLING IKEENPEIWT
260 270 280 290 300
TELQQEIIEM IQRAVDLEID YARDCLPRGI LGLRASMFID YVQHIADRRL
310 320 330 340
ERIGLKPIYH TKNPFPWMSE TIDLNKEKNF FETRVTEYQH AASLTW
Length:346
Mass (Da):40,488
Last modified:October 1, 2000 - v1
Checksum:iC5AF2C3372FBDA57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF39087.1.
PIRiG81728.
RefSeqiWP_010229839.1. NZ_ACOV01000003.1.

Genome annotation databases

EnsemblBacteriaiAAF39087; AAF39087; TC_0215.
GeneIDi1246341.
KEGGicmu:TC_0215.
PATRICi20371812. VBIChlMur19118_0235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA. Translation: AAF39087.1.
PIRiG81728.
RefSeqiWP_010229839.1. NZ_ACOV01000003.1.

3D structure databases

ProteinModelPortaliQ9PL92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243161.CmurN_010100001073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF39087; AAF39087; TC_0215.
GeneIDi1246341.
KEGGicmu:TC_0215.
PATRICi20371812. VBIChlMur19118_0235.

Phylogenomic databases

eggNOGiENOG4105E05. Bacteria.
COG0208. LUCA.
KOiK00526.
OMAiCNRRCQQ.

Enzyme and pathway databases

UniPathwayiUPA00326.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR033909. RNR_small.
IPR000358. RNR_small_fam.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRIR2_CHLMU
AccessioniPrimary (citable) accession number: Q9PL92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.