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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54S-adenosyl-L-methionineUniRule annotation1
Binding sitei79S-adenosyl-L-methionineUniRule annotation1
Binding sitei106S-adenosyl-L-methionineUniRule annotation1
Active sitei129By similarity1
Binding sitei129S-adenosyl-L-methionineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Binding sitei165SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:TC_0216
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000800 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001713151 – 224tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST224

Interactioni

Protein-protein interaction databases

STRINGi243161.CmurN_010100001078

Structurei

3D structure databases

ProteinModelPortaliQ9PL91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ1 Bacteria
COG0220 LUCA
KOiK03439
OMAiGHALEYC

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9PL91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQDLKLPY FWEDRCPKIE NHVFYVPSYY PKYEEFVMPS WQNLFANEGP
60 70 80 90 100
VCCELCSGNG DWVVEQALKD TSINWIAVEK RFDRVRKIWS KMSNHKVNNL
110 120 130 140 150
LIVCGEAQTF FTHYVTDASF QKIVVNFPDP WPKFRHRKHR LFQDVFVQDM
160 170 180 190 200
VRVLVEGGQL TLVTDDHTYL TNSIQVMLNY LSPGMQDPYY VNVKDNYGGS
210 220
WFENLWRSKG EKIFCTEFVK RVGI
Length:224
Mass (Da):26,516
Last modified:October 1, 2000 - v1
Checksum:i8DC9A831A7B8A700
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE002160 Genomic DNA Translation: AAF39088.1
PIRiF81726

Genome annotation databases

EnsemblBacteriaiAAF39088; AAF39088; TC_0216
KEGGicmu:TC_0216

Similar proteinsi

Entry informationi

Entry nameiTRMB_CHLMU
AccessioniPrimary (citable) accession number: Q9PL91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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