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Q9PL77

- PNP_CHLMU

UniProt

Q9PL77 - PNP_CHLMU

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi485 – 4851MagnesiumUniRule annotation
Metal bindingi491 – 4911MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:TC_0230
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 693693Polyribonucleotide nucleotidyltransferasePRO_0000329578Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243161.TC0230.

Structurei

3D structure databases

ProteinModelPortaliQ9PL77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61160KHUniRule annotationAdd
BLAST
Domaini621 – 68969S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiTHEIMEQ.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PL77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFETFSVAL DKDKTLIFET GKIARQANGA VLVKMNETWV FSSACAASLS
60 70 80 90 100
EAVDFLPFRV DYQEKFSSAG KTSGGFLKRE GRPSEKEILI SRLIDRSLRP
110 120 130 140 150
SFPNRLMQDI QVLSYVWSYD GKTLPDPLAI CGASAALAIS EVPQNCIVAG
160 170 180 190 200
VRVGLVEGKW VVNPTKDELD ASKLDLVMAG TASAVLMIEG HCDFLTEEQV
210 220 230 240 250
LEAIAFGQKY IAKICDAIEA WQKAIGKEKQ LSAVLDLPED VQNVVSNFIR
260 270 280 290 300
EKFEKALSFR DRDALEQVSK ELEESVVANL VQEESDFSLL NVKAAFKNAK
310 320 330 340 350
SNQMRALIRD LGIRVDGRST TEIRPISIEV SFLPRTHGSC LFTRGETQSV
360 370 380 390 400
AVCTLGGESM AQRFEDLNGD GAARFYLQYF FPPFSVGEVG RIGSPGRREI
410 420 430 440 450
GHGKLAEKAL SHVLPEASRF PYTVRVESNI TESNGSSSMA SVCGGCLSLM
460 470 480 490 500
DAGVPIKAPV AGIAMGLILD QDKAIVLSDI SGIEDHLGDM DFKVAGTEEG
510 520 530 540 550
ITAFQMDIKV EGITHEIMEQ ALAQAKQGRS HILNLMTQVM SSPNDSVSRY
560 570 580 590 600
APRIETMQIN TSKIATVIGP GGKQIRQIIE RSGAQVDIND NGLINISANT
610 620 630 640 650
QESIDKAKEL IEGLTGEVEV GKIYNGRVTS VVAFGAFVEV LPGKEGLCHI
660 670 680 690
SELSKQKVDN VADFVKEGDR LAVKLLSINE KGQLKLSHKA TLE
Length:693
Mass (Da):75,334
Last modified:October 1, 2000 - v1
Checksum:i1686F6EE8249AD9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39102.1.
PIRiG81725.
RefSeqiNP_296609.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39102; AAF39102; TC_0230.
GeneIDi1246399.
KEGGicmu:TC_0230.
PATRICi20371848. VBIChlMur19118_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39102.1 .
PIRi G81725.
RefSeqi NP_296609.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PL77.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39102 ; AAF39102 ; TC_0230 .
GeneIDi 1246399.
KEGGi cmu:TC_0230.
PATRICi 20371848. VBIChlMur19118_0251.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi THEIMEQ.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CMUR243161:GHYU-243-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry nameiPNP_CHLMU
AccessioniPrimary (citable) accession number: Q9PL77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3