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Q9PKX7

- 6PGD_CHLMU

UniProt

Q9PKX7 - 6PGD_CHLMU

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene
gnd, TC_0333
Organism
Chlamydia muridarum (strain MoPn / Nigg)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity.

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031NADP By similarity
Binding sitei103 – 1031Substrate By similarity
Active sitei183 – 1831Proton acceptor By similarity
Active sitei190 – 1901Proton donor By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei260 – 2601Substrate; via amide nitrogen By similarity
Binding sitei287 – 2871Substrate By similarity
Binding sitei447 – 4471Substrate; shared with dimeric partner By similarity
Binding sitei453 – 4531Substrate; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADP By similarity
Nucleotide bindingi33 – 353NADP By similarity
Nucleotide bindingi75 – 773NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCMUR243161:GHYU-349-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:TC_0333
OrganismiChlamydia muridarum (strain MoPn / Nigg)
Taxonomic identifieri243161 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000800: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4794796-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090031Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi243161.TC0333.

Structurei

3D structure databases

ProteinModelPortaliQ9PKX7.
SMRiQ9PKX7. Positions 2-473.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni129 – 1313Substrate binding By similarity
Regioni186 – 1872Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
KOiK00033.
OMAiEAYFFMK.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9PKX7-1 [UniParc]FASTAAdd to Basket

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MAPADIGLIG LAVMGKNLVL NMIDHGFAVS VYNRSPEKTE EFLKEHGENI    50
SLQGFTAIEE FVQSLKRPRK IMIMIKAGAP VDEMISSLLP FLEEGDILID 100
GGNSYYLDSE RRYIDLKKKG ILFVGMGVSG GEEGARKGPS IMPGGNIEAW 150
PVIAPIFQSI AAQVDGQPCC SWIGTGGAGH FVKAVHNGIE YGDIQLICET 200
YEILKSRLDL SLEQIGNIFF EWNQTDLNSY LMGASAAVLT AKDENGVAVA 250
STILDVAGQK GTGRWVAEDA IKAGVPMSLI IESVLARYLS AWKEVRRQAA 300
REFPVASLLY QPSQEASVLI EDAREALYAA KIISYAQGFM LLKQISEERN 350
WDLNLGELAL IWRGGCIIQS AFLDKIHQGF ESCPDAHSLM LQDYFKNVLL 400
NSETGFRRAI LHAVGAGVAI PCLASALAFY DGYRTENSPL FLVQGLRDYF 450
GAHGYERQDR PRGEFYHTDW LGSKNASRM 479
Length:479
Mass (Da):52,689
Last modified:October 1, 2000 - v1
Checksum:i3501DD6DAA0B8F8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39196.1.
PIRiA81714.
RefSeqiNP_296712.1. NC_002620.2.

Genome annotation databases

EnsemblBacteriaiAAF39196; AAF39196; TC_0333.
GeneIDi1246377.
KEGGicmu:TC_0333.
PATRICi20372076. VBIChlMur19118_0362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE002160 Genomic DNA. Translation: AAF39196.1 .
PIRi A81714.
RefSeqi NP_296712.1. NC_002620.2.

3D structure databases

ProteinModelPortali Q9PKX7.
SMRi Q9PKX7. Positions 2-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243161.TC0333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF39196 ; AAF39196 ; TC_0333 .
GeneIDi 1246377.
KEGGi cmu:TC_0333.
PATRICi 20372076. VBIChlMur19118_0362.

Phylogenomic databases

eggNOGi COG0362.
KOi K00033.
OMAi EAYFFMK.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci CMUR243161:GHYU-349-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MoPn / Nigg.

Entry informationi

Entry namei6PGD_CHLMU
AccessioniPrimary (citable) accession number: Q9PKX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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