Reviewed, UniProtKB/Swiss-Prot Q9PKX7 (6PGD_CHLMU)

Names and origin

Protein names

Recommended name:
    6-phosphogluconate dehydrogenase, decarboxylating
    EC=1.1.1.44

Gene names

Name:	gnd
Ordered Locus Names:	TC_0333

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family.

Ontologies

Keywords
Biological process	Gluconate utilization Pentose shunt
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	6-phosphogluconate dehydrogenase, decarboxylating		PRO_0000090031

Sequences

	Sequence		Length	Mass (Da)
	Q9PKX7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3501DD6DAA0B8F8B	FASTA	479	52,689
	10 20 30 40 50 60 MAPADIGLIG LAVMGKNLVL NMIDHGFAVS VYNRSPEKTE EFLKEHGENI SLQGFTAIEE 70 80 90 100 110 120 FVQSLKRPRK IMIMIKAGAP VDEMISSLLP FLEEGDILID GGNSYYLDSE RRYIDLKKKG 130 140 150 160 170 180 ILFVGMGVSG GEEGARKGPS IMPGGNIEAW PVIAPIFQSI AAQVDGQPCC SWIGTGGAGH 190 200 210 220 230 240 FVKAVHNGIE YGDIQLICET YEILKSRLDL SLEQIGNIFF EWNQTDLNSY LMGASAAVLT 250 260 270 280 290 300 AKDENGVAVA STILDVAGQK GTGRWVAEDA IKAGVPMSLI IESVLARYLS AWKEVRRQAA 310 320 330 340 350 360 REFPVASLLY QPSQEASVLI EDAREALYAA KIISYAQGFM LLKQISEERN WDLNLGELAL 370 380 390 400 410 420 IWRGGCIIQS AFLDKIHQGF ESCPDAHSLM LQDYFKNVLL NSETGFRRAI LHAVGAGVAI 430 440 450 460 470 PCLASALAFY DGYRTENSPL FLVQGLRDYF GAHGYERQDR PRGEFYHTDW LGSKNASRM

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF39196.1.
PIR	A81714.
RefSeq	NP_296712.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ModBase	Search...
Genome annotation databases
GeneID	1246377.
GenomeReviews	Gene locus TC_0333 in contig AE002160_GR.
KEGG	cmu:TC0333.
TIGR	TC_0333.
Phylogenomic databases
HOGENOM	Q9PKX7.
OMA	Q9PKX7. SHYKEER.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0333-MON.
BRENDA	1.1.1.44. 256349.
Family and domain databases
InterPro	IPR006183. 6-phosphogluconate_DH. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NAD-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PRINTS	PR00076. 6PGDHDRGNASE.
TIGRFAMs	TIGR00873. gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

6PGD_CHLMU

Accession

Primary (citable) accession number: Q9PKX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)